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公开(公告)号：US20090274718A1
公开(公告)日：2009-11-05
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
IPC分类号： A61K39/07 , C07K14/245 , A61K38/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US07566457B2
公开(公告)日：2009-07-28
申请号：US11705696
申请日：2007-02-13
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonspecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US07279164B2
公开(公告)日：2007-10-09
申请号：US10484114
申请日：2002-07-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
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4.发明申请Pharmaceutical Compound Capable of Induce Immune Protective Response Against Dengue Virus Having the Capsid Protein of the Dengue Virus 有权能够对具有登革热病毒的衣壳蛋白的登革热病毒诱导免疫保护作用的药物化合物公开(公告)号：US20080311157A1
公开(公告)日：2008-12-18
申请号：US12067129
申请日：2006-09-18
申请人： Laura Lazo Vazquez , Lisset Hermida Cruz , Carlos Lopez Abarrategui , Beatriz de la Caridad Sierra Vazquez , Susana Vazquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe GuzmanTirado , Aida Zulueta Morales
发明人： Laura Lazo Vazquez , Lisset Hermida Cruz , Carlos Lopez Abarrategui , Beatriz de la Caridad Sierra Vazquez , Susana Vazquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe GuzmanTirado , Aida Zulueta Morales
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describe the a pharmaceutical compound having the capsid protein of Dengue virus capable of induce in the receptor a protective immune response before the viral challenge without inducing the Ab-dependent enhancement phenomenon.
摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的药物化合物，其能够在病毒攻击之前在受体中诱导保护性免疫应答，而不诱导Ab依赖性增强现象。
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公开(公告)号：US08105606B2
公开(公告)日：2012-01-31
申请号：US13094287
申请日：2011-04-26
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US20110200628A1
公开(公告)日：2011-08-18
申请号：US13094287
申请日：2011-04-26
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US07947281B2
公开(公告)日：2011-05-24
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Richardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Richardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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8.发明授权Pharmaceutical compound capable of induce immune protective response against Dengue virus having the capsid protein of the Dengue virus 有权能够对具有登革热病毒衣壳蛋白的登革热病毒诱导免疫保护作用的药物化合物公开(公告)号：US07790173B2
公开(公告)日：2010-09-07
申请号：US12067129
申请日：2006-09-18
申请人： Laura Lazo Vázquez , Lisset Hermida Cruz , Carlos López Abarrategui , Beatriz de la Caridad Sierra Vázquez , Susana Vázquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzmán Tirado , Aida Zulueta Morales
发明人： Laura Lazo Vázquez , Lisset Hermida Cruz , Carlos López Abarrategui , Beatriz de la Caridad Sierra Vázquez , Susana Vázquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzmán Tirado , Aida Zulueta Morales
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describes a pharmaceutical compound which has the capsid protein of Dengue virus and which is capable of inducing, in the receptor, a protective immune response before the viral challenge, without inducing the Ab-dependent enhancement phenomenon.
摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的能够在病毒攻击之前在受体中诱导保护性免疫应答而不诱导依赖于Ab的增强现象的药物化合物。
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