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公开(公告)号：US07947281B2
公开(公告)日：2011-05-24
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Richardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Richardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US08105606B2
公开(公告)日：2012-01-31
申请号：US13094287
申请日：2011-04-26
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US20110200628A1
公开(公告)日：2011-08-18
申请号：US13094287
申请日：2011-04-26
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US20090274718A1
公开(公告)日：2009-11-05
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
IPC分类号： A61K39/07 , C07K14/245 , A61K38/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US07566457B2
公开(公告)日：2009-07-28
申请号：US11705696
申请日：2007-02-13
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonspecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US07279164B2
公开(公告)日：2007-10-09
申请号：US10484114
申请日：2002-07-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
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7.发明申请Pharmaceutical Compound Capable of Induce Immune Protective Response Against Dengue Virus Having the Capsid Protein of the Dengue Virus 有权能够对具有登革热病毒的衣壳蛋白的登革热病毒诱导免疫保护作用的药物化合物公开(公告)号：US20080311157A1
公开(公告)日：2008-12-18
申请号：US12067129
申请日：2006-09-18
申请人： Laura Lazo Vazquez , Lisset Hermida Cruz , Carlos Lopez Abarrategui , Beatriz de la Caridad Sierra Vazquez , Susana Vazquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe GuzmanTirado , Aida Zulueta Morales
发明人： Laura Lazo Vazquez , Lisset Hermida Cruz , Carlos Lopez Abarrategui , Beatriz de la Caridad Sierra Vazquez , Susana Vazquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe GuzmanTirado , Aida Zulueta Morales
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describe the a pharmaceutical compound having the capsid protein of Dengue virus capable of induce in the receptor a protective immune response before the viral challenge without inducing the Ab-dependent enhancement phenomenon.
摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的药物化合物，其能够在病毒攻击之前在受体中诱导保护性免疫应答，而不诱导Ab依赖性增强现象。
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8.发明授权Pharmaceutical compound capable of induce immune protective response against Dengue virus having the capsid protein of the Dengue virus 有权能够对具有登革热病毒衣壳蛋白的登革热病毒诱导免疫保护作用的药物化合物公开(公告)号：US07790173B2
公开(公告)日：2010-09-07
申请号：US12067129
申请日：2006-09-18
申请人： Laura Lazo Vázquez , Lisset Hermida Cruz , Carlos López Abarrategui , Beatriz de la Caridad Sierra Vázquez , Susana Vázquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzmán Tirado , Aida Zulueta Morales
发明人： Laura Lazo Vázquez , Lisset Hermida Cruz , Carlos López Abarrategui , Beatriz de la Caridad Sierra Vázquez , Susana Vázquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzmán Tirado , Aida Zulueta Morales
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describes a pharmaceutical compound which has the capsid protein of Dengue virus and which is capable of inducing, in the receptor, a protective immune response before the viral challenge, without inducing the Ab-dependent enhancement phenomenon.
摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的能够在病毒攻击之前在受体中诱导保护性免疫应答而不诱导依赖于Ab的增强现象的药物化合物。
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9.发明申请Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses 审中-公开用于预防和/或治疗四种登革热病毒和其他黄病毒血清型的方法和蛋白质公开(公告)号：US20090312190A1
公开(公告)日：2009-12-17
申请号：US12094503
申请日：2006-11-21
申请人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes
发明人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes
IPC分类号： C40B30/02 , A61K39/00 , A61K39/12 , C12N7/00 , C12N5/00 , C40B30/04 , C40B40/10 , C07K16/00 , C07H21/04 , A61K39/02
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/55566 , C07K2319/02 , C07K2319/21 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.
摘要翻译： 本发明涉及制药工业的领域，并且描述了可用于开发用于预防和/或治疗感染的广谱抗病毒分子的E蛋白表面上的保守区域 由于登革热病毒血清型1-4和其他黄病毒。 本发明还涵盖用作疫苗的嵌合蛋白或针对登革热病毒和其他黄病毒的四种血清型的预防或治疗性治疗。
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