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1.发明授权Pharmaceutical compound capable of induce immune protective response against Dengue virus having the capsid protein of the Dengue virus 有权能够对具有登革热病毒衣壳蛋白的登革热病毒诱导免疫保护作用的药物化合物公开(公告)号：US07790173B2
公开(公告)日：2010-09-07
申请号：US12067129
申请日：2006-09-18
申请人： Laura Lazo Vázquez , Lisset Hermida Cruz , Carlos López Abarrategui , Beatriz de la Caridad Sierra Vázquez , Susana Vázquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzmán Tirado , Aida Zulueta Morales
发明人： Laura Lazo Vázquez , Lisset Hermida Cruz , Carlos López Abarrategui , Beatriz de la Caridad Sierra Vázquez , Susana Vázquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzmán Tirado , Aida Zulueta Morales
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describes a pharmaceutical compound which has the capsid protein of Dengue virus and which is capable of inducing, in the receptor, a protective immune response before the viral challenge, without inducing the Ab-dependent enhancement phenomenon.
摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的能够在病毒攻击之前在受体中诱导保护性免疫应答而不诱导依赖于Ab的增强现象的药物化合物。
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2.发明申请Pharmaceutical Compound Capable of Induce Immune Protective Response Against Dengue Virus Having the Capsid Protein of the Dengue Virus 有权能够对具有登革热病毒的衣壳蛋白的登革热病毒诱导免疫保护作用的药物化合物公开(公告)号：US20080311157A1
公开(公告)日：2008-12-18
申请号：US12067129
申请日：2006-09-18
申请人： Laura Lazo Vazquez , Lisset Hermida Cruz , Carlos Lopez Abarrategui , Beatriz de la Caridad Sierra Vazquez , Susana Vazquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe GuzmanTirado , Aida Zulueta Morales
发明人： Laura Lazo Vazquez , Lisset Hermida Cruz , Carlos Lopez Abarrategui , Beatriz de la Caridad Sierra Vazquez , Susana Vazquez Ramundo , Iris Valdez Prado , Gerardo Enrique Guillen Nieto , Maria Guadalupe GuzmanTirado , Aida Zulueta Morales
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describe the a pharmaceutical compound having the capsid protein of Dengue virus capable of induce in the receptor a protective immune response before the viral challenge without inducing the Ab-dependent enhancement phenomenon.
摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的药物化合物，其能够在病毒攻击之前在受体中诱导保护性免疫应答，而不诱导Ab依赖性增强现象。
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公开(公告)号：US20090274718A1
公开(公告)日：2009-11-05
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
IPC分类号： A61K39/07 , C07K14/245 , A61K38/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US07566457B2
公开(公告)日：2009-07-28
申请号：US11705696
申请日：2007-02-13
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonspecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US07279164B2
公开(公告)日：2007-10-09
申请号：US10484114
申请日：2002-07-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
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公开(公告)号：US08105606B2
公开(公告)日：2012-01-31
申请号：US13094287
申请日：2011-04-26
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US20110200628A1
公开(公告)日：2011-08-18
申请号：US13094287
申请日：2011-04-26
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US07947281B2
公开(公告)日：2011-05-24
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Richardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Richardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US08569470B2
公开(公告)日：2013-10-29
申请号：US12739658
申请日：2008-10-17
申请人： Diógenes Quintana Vázquez , Tamara Menendez Medina , Anabel Álvarez Acosta , Yoelys Cruz Leal , Gerardo Enrique Guillen Nieto
发明人： Diógenes Quintana Vázquez , Tamara Menendez Medina , Anabel Álvarez Acosta , Yoelys Cruz Leal , Gerardo Enrique Guillen Nieto
CPC分类号： G01N33/56911 , A61K39/00 , A61K39/099 , A61K2039/522 , A61K2039/523 , A61K2039/53 , C07K14/235 , Y02A50/466
摘要： The present invention is related with the field of Biomedicine. It comprises the engineering of the Pertactin protein (Prn) and using it as part of bacterial vaccines, and more precisely, as part of acellular vaccines against Bordetella pertusis. The engineered Prn molecules comprise on their structure polimorfisms from different B. pertussis strains, and induce immune responses with protective capacity and opsonophagocytic activity when assayed as vaccines, higher than that generated by other pre-existing vaccines. The engineered Prn variants of the present invention are applicable in human and veterinary medicine.
摘要翻译： 本发明涉及生物医学领域。 它包括Pertactin蛋白（Prn）的工程，并将其用作细菌疫苗的一部分，更确切地说，它是作为针对博德氏菌的无细胞疫苗的一部分。 工程化的Prn分子在其结构上包括来自不同的百日咳杆菌菌株的结构，并且当测定为疫苗时诱导具有保护能力和调理吞噬活性的免疫应答，高于其他预先存在的疫苗产生的疫苗。 本发明的工程化Prn变体可应用于人兽药。
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10.发明申请PHARMACEUTICAL COMPOSITION USING GONADOTROPIN - RELEASING HORMONE (GNRH) COMBINED VARIANTS AS IMMUNOGEN 有权使用GONADOTROPIN - 释放HORMONE（GNRH）组合的变体作为免疫球蛋白的药物组合物公开(公告)号：US20110250196A1
公开(公告)日：2011-10-13
申请号：US13121915
申请日：2009-09-30
申请人： Jesus Arturo Junco Barranco , Osvaldo Reyes Acosta , Eddy Emilio Bover Fuentes , Franklin Fuentes Aguilar , Eulogio Pimentel Vazquez , Roberto Basulto Baker , Gerardo Enrique Guillen Nieto , Yovisleidys Lopez Saez , Hilda Elisa Garay Perez , Lesvia Calzada Aguilera , Maria Castro Santana , Niurka Oneysi Arteaga More , Luis Alberto Aguero Barrocal
发明人： Jesus Arturo Junco Barranco , Osvaldo Reyes Acosta , Eddy Emilio Bover Fuentes , Franklin Fuentes Aguilar , Eulogio Pimentel Vazquez , Roberto Basulto Baker , Gerardo Enrique Guillen Nieto , Yovisleidys Lopez Saez , Hilda Elisa Garay Perez , Lesvia Calzada Aguilera , Maria Castro Santana , Niurka Oneysi Arteaga More , Luis Alberto Aguero Barrocal
IPC分类号： A61K39/395 , A61P35/00 , A61P37/04 , A61K39/00
CPC分类号： A61K39/0011 , A61K38/09 , A61K39/0006 , A61K47/48261 , A61K47/4833 , A61K47/6415 , A61K47/646 , A61K2039/585 , A61K2039/6037 , A61K2300/00
摘要： A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.
摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。
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