公开(公告)号：US08242151B2

公开(公告)日：2012-08-14

申请号：US12162119

申请日：2008-02-07

申请人： Arata Yanagisawa ,  Takeshi Kuboyama ,  Seiji Aratake ,  Kazuki Hemmi ,  Kimihisa Ueno ,  Michihiko Suzuki ,  Masahiro Matsubara ,  Kozo Yao ,  Akinori Hamaguchi ,  Yukihito Tsukumo

发明人： Arata Yanagisawa ,  Takeshi Kuboyama ,  Seiji Aratake ,  Kazuki Hemmi ,  Kimihisa Ueno ,  Michihiko Suzuki ,  Masahiro Matsubara ,  Kozo Yao ,  Akinori Hamaguchi ,  Yukihito Tsukumo

IPC分类号： A01N43/82 ,  A01N61/00 ,  A01N43/50 ,  A61K31/41 ,  A61K31/00 ,  A61K31/415

CPC分类号： C07D403/14 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/55 ,  C07D413/10 ,  C07D413/14 ,  C07D471/04

摘要： The present invention provides a PPAR γ agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH═CH—CH═CH or the like, Y represents a single bond or the like, Z1-Z2 represents C═CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.

摘要翻译： 本发明提供一种PPARγ激动剂，其包含作为活性成分的由式（I）表示的三环化合物（其中R 1表示任选具有取代基的低级烷基等），R2和R3相同或不同， 各自表示任选具有取代基等的低级烷基，R4和R5相同或不同，各自表示氢原子等，Q1-Q2-Q3表示CH = CH-CH = CH等，Y 表示单键或类似物，Z1-Z2表示C = CR13（其中R13表示氢原子等）等，A表示-COOH等）或其药学上可接受的盐等 。

公开(公告)号：US20090176760A1

公开(公告)日：2009-07-09

申请号：US12162119

申请日：2008-02-07

申请人： Arata Yanagisawa ,  Takeshi Kuboyama ,  Seiji Aratake ,  Kazuki Hemmi ,  Kimihisa Ueno ,  Michihiko Suzuki ,  Masahiro Matsubara ,  Kozo Yao ,  Akinori Hamaguchi ,  Yukihito Tsukumo

发明人： Arata Yanagisawa ,  Takeshi Kuboyama ,  Seiji Aratake ,  Kazuki Hemmi ,  Kimihisa Ueno ,  Michihiko Suzuki ,  Masahiro Matsubara ,  Kozo Yao ,  Akinori Hamaguchi ,  Yukihito Tsukumo

IPC分类号： A61K31/55 ,  C07D471/04 ,  A61P3/10

CPC分类号： C07D403/14 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/55 ,  C07D413/10 ,  C07D413/14 ,  C07D471/04

摘要： The present invention provides a PPAR γ agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH═CH—CH═CH or the like, Y represents a single bond or the like, Z1-Z2 represents C═CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.

摘要翻译： 本发明提供一种PPARγ激动剂，其包含作为活性成分的由式（I）表示的三环化合物（其中R 1表示任选具有取代基的低级烷基等），R2和R3相同或不同， 各自表示任选具有取代基等的低级烷基，R4和R5相同或不同，各自表示氢原子等，Q1-Q2-Q3表示CH-CH-CH-CH等，Y 表示单键或类似物，Z1-Z2表示C-CR13（其中R13表示氢原子等）等，A表示-COOH等）或其药学上可接受的盐等 。