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17 条记录 (耗时 0.017 秒)

    INHIBITORS OF ION CHANNELS
    1.
    发明申请
    INHIBITORS OF ION CHANNELS 失效
    离子通道的抑制剂

    公开(公告)号：US20100234343A1

    公开(公告)日：2010-09-16

    申请号：US12729193

    申请日：2010-03-22

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： A61K31/397 ,  C07D417/12 ,  A61K31/427 ,  A61K31/4439 ,  A61P25/00

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    Inhibitors of ion channels
    4.
    发明授权
    Inhibitors of ion channels 失效
    离子通道抑制剂

    公开(公告)号：US08338608B2

    公开(公告)日：2012-12-25

    申请号：US12729193

    申请日：2010-03-22

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： C07D417/12 ,  A61K31/4436

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    Pull Strap Assembly for a Sliding Closure
    5.
    发明申请
    Pull Strap Assembly for a Sliding Closure 审中-公开
    拉带组件用于滑动关闭

    公开(公告)号：US20090013497A1

    公开(公告)日：2009-01-15

    申请号：US11776925

    申请日：2007-07-12

    申请人： Jerrell P. Squyres ,  Kelly Lee Miller ,  Keith Alan Fulp

    发明人： Jerrell P. Squyres ,  Kelly Lee Miller ,  Keith Alan Fulp

    IPC分类号： E05F1/00

    CPC分类号： E05F11/54 ,  E05D15/24 ,  E05Y2900/106 ,  Y10T16/56

    摘要： Disclosed is a pull strap assembly for attaching to a sliding closure such as a door on the rear of a semitrailer. The pull strap assembly comprises a first band attached to the sliding closure and a second band attached to the first band to prevent the first band from hanging out of the cargo enclosure when the sliding closure is in the closed position.

    摘要翻译： 公开了一种拉带组件，用于附接到滑动闭合件，例如半挂车后部的门。 拉带组件包括附接到滑动闭合件的第一带和附接到第一带的第二带，以防止当滑动封闭件处于关闭位置时第一带悬挂在货舱外。

    INHIBITORS OF ION CHANNELS
    6.
    发明申请
    INHIBITORS OF ION CHANNELS 失效
    离子通道的抑制剂

    公开(公告)号：US20070135493A1

    公开(公告)日：2007-06-14

    申请号：US11555977

    申请日：2006-11-02

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： A61K31/513 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/426 ,  C07D417/02

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与发作相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    Inhibitors of ion channels
    7.
    发明授权
    Inhibitors of ion channels 失效
    离子通道抑制剂

    公开(公告)号：US07705158B2

    公开(公告)日：2010-04-27

    申请号：US11555977

    申请日：2006-11-02

    申请人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    发明人： Xiaodong Wang ,  Alan Fulp ,  Brian Marron ,  Serge Beaudoin ,  Darrick Seconi ,  Mark Suto

    IPC分类号： A61K31/427 ,  C07D277/46

    CPC分类号： C07D277/52 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供取代的芳基磺酰胺，包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与起始相关的钠通道或 指示条件复发。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    Inhibitors of ion channels
    8.
    发明授权
    Inhibitors of ion channels 失效
    离子通道抑制剂

    公开(公告)号：US07615569B2

    公开(公告)日：2009-11-10

    申请号：US11464057

    申请日：2006-08-11

    申请人： Alan Fulp ,  Brian Marron ,  Mark J. Suto ,  Xiaodong Wang

    发明人： Alan Fulp ,  Brian Marron ,  Mark J. Suto ,  Xiaodong Wang

    IPC分类号： A61K31/427 ,  A61K31/513 ,  C07D283/02 ,  C07D277/52 ,  C07D277/28 ,  C07D403/10

    CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供了可用于治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的杂环芳基磺酰胺，组合物和方法，其通过阻断与所述病症的发作或复发相关的钠通道。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。

    INHIBITORS OF ION CHANNELS
    9.
    发明申请
    INHIBITORS OF ION CHANNELS 失效
    离子通道的抑制剂

    公开(公告)号：US20070078145A1

    公开(公告)日：2007-04-05

    申请号：US11464057

    申请日：2006-08-11

    申请人： Alan Fulp ,  Brian Marron ,  Mark Suto ,  Xiaodong Wang

    发明人： Alan Fulp ,  Brian Marron ,  Mark Suto ,  Xiaodong Wang

    IPC分类号： A61K31/513 ,  A61K31/497 ,  A61K31/4965 ,  A61K31/4439 ,  A61K31/427 ,  A61K31/426 ,  A61K31/4196 ,  A61K31/4192 ,  A61K31/4178 ,  A61K31/4152 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

    CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D417/14

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

    摘要翻译： 提供了可用于通过电压门控钠通道抑制钠离子通量来治疗疾病的化合物，组合物和方法。 更具体地，本发明提供了可用于治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的杂环芳基磺酰胺，组合物和方法，其通过阻断与所述病症的发作或复发相关的钠通道。 本发明的化合物，组合物和方法特别用于通过电压门控钠通道抑制离子通量来治疗神经性或炎性疼痛。