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公开(公告)号:US20050227989A1
公开(公告)日:2005-10-13
申请号:US11105665
申请日:2005-04-13
申请人: Xiaodong Wang , Kerry Spear , Alan Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo , Hideki Kubota
发明人: Xiaodong Wang , Kerry Spear , Alan Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo , Hideki Kubota
IPC分类号: A61K9/20 , A61K9/48 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , C07D417/02
CPC分类号: C07D417/14
摘要: The present invention provides a genus of polycyclic thiazoles that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译: 本发明提供了可用作钾离子通道调节剂的多环噻唑属。 本发明的调节剂在治疗和诊断方法中都有用。
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公开(公告)号:US20080108600A1
公开(公告)日:2008-05-08
申请号:US10592985
申请日:2005-04-13
申请人: Xiaodong Wang , Kerry L. Spear , Alan B. Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo , Hideki Kubota , Jun-ichi Kazami
发明人: Xiaodong Wang , Kerry L. Spear , Alan B. Fulp , Darrick Seconi , Takeshi Suzuki , Takahiro Ishii , Ayako Moritomo , Hideki Kubota , Jun-ichi Kazami
IPC分类号: A61K31/444 , C12N5/00 , A61P25/00 , A61P1/00 , A61P9/00 , A61K31/496 , A61K31/551 , A61K31/5377 , A61K31/497 , C07D417/14 , C07D401/14 , A61K31/4725
CPC分类号: C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要: The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译: 本发明提供了可用作钾离子通道调节剂的多环吡啶属。 本发明的调节剂在治疗和诊断方法中都有用。
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公开(公告)号:US07375222B2
公开(公告)日:2008-05-20
申请号:US10503494
申请日:2003-02-03
申请人: Hideki Kubota , Takeshi Suzuki , Masanori Miura , Eiichi Nakai , Kiyoshi Yahiro , Akira Miyake , Shinobu Mochizuki , Kazuhiro Nakatou
发明人: Hideki Kubota , Takeshi Suzuki , Masanori Miura , Eiichi Nakai , Kiyoshi Yahiro , Akira Miyake , Shinobu Mochizuki , Kazuhiro Nakatou
IPC分类号: C07D251/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/53 , A61P25/28
CPC分类号: C07D471/04 , A61K31/53 , C07D251/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D491/04
摘要: This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient.It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned.Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder.Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.
摘要翻译: 本发明涉及使用BEC 1钾通道抑制剂作为活性成分的抗痴呆药。 证明BEC 1钾通道抑制剂具有改善学习障碍的作用,可用作预防或治疗BEC 1钾通道所涉及的疾病,优选痴呆症。 说明性地,通过体内试验证实BEC 1钾通道抑制剂具有改善学习障碍的作用。 此外,发现具有2,4,6-三氨基-1,3,5-三嗪的化合物具有BEC 1钾通道抑制作用。
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公开(公告)号:US20060194803A1
公开(公告)日:2006-08-31
申请号:US10503494
申请日:2003-02-03
申请人: Hideki Kubota , Takeshi Suzuki , Masanori Miura , Eiichi Nakai , Kiyoshi Yahiro , Akira Miyake , Shinobu Nakatou , Kazuhiro Nakatou
发明人: Hideki Kubota , Takeshi Suzuki , Masanori Miura , Eiichi Nakai , Kiyoshi Yahiro , Akira Miyake , Shinobu Nakatou , Kazuhiro Nakatou
IPC分类号: A61K31/53 , C07D403/02 , C07D251/54
CPC分类号: C07D471/04 , A61K31/53 , C07D251/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D491/04
摘要: This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient. It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned. Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder. Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.
摘要翻译: 本发明涉及使用BEC 1钾通道抑制剂作为活性成分的抗痴呆药。 证明BEC 1钾通道抑制剂具有改善学习障碍的作用,可用作预防或治疗BEC 1钾通道所涉及的疾病,优选痴呆症。 说明性地,通过体内试验证实BEC 1钾通道抑制剂具有改善学习障碍的作用。 此外,发现具有2,4,6-三氨基-1,3,5-三嗪的化合物具有BEC 1钾通道抑制作用。
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公开(公告)号:US20080227785A1
公开(公告)日:2008-09-18
申请号:US12027246
申请日:2008-02-06
申请人: Hideki Kubota , Takeshi Suzuki , Masanori Miura , Eiichi Nakai , Kiyoshi Yahiro , Akira Miyake , Shinobu Mochizuki , Kazuhiro Nakatou
发明人: Hideki Kubota , Takeshi Suzuki , Masanori Miura , Eiichi Nakai , Kiyoshi Yahiro , Akira Miyake , Shinobu Mochizuki , Kazuhiro Nakatou
IPC分类号: A61K31/53
CPC分类号: C07D471/04 , A61K31/53 , C07D251/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D491/04
摘要: This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient.It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned.Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder.Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.
摘要翻译: 本发明涉及使用BEC 1钾通道抑制剂作为活性成分的抗痴呆药。 证明BEC 1钾通道抑制剂具有改善学习障碍的作用,可用作预防或治疗BEC 1钾通道所涉及的疾病,优选痴呆症。 说明性地,通过体内试验证实BEC 1钾通道抑制剂具有改善学习障碍的作用。 此外,发现具有2,4,6-三氨基-1,3,5-三嗪的化合物具有BEC 1钾通道抑制作用。
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公开(公告)号:US20060241302A1
公开(公告)日:2006-10-26
申请号:US10561838
申请日:2004-06-29
申请人: Hideki Kubota , Takanori Yasukouchi , Satoru Miyauchi , Kayoko Motoki , Masanori Saito , Hitoshi Iimori
发明人: Hideki Kubota , Takanori Yasukouchi , Satoru Miyauchi , Kayoko Motoki , Masanori Saito , Hitoshi Iimori
IPC分类号: C07D403/02 , C07D401/02 , C07D213/02
CPC分类号: C07D213/30 , C07C317/14 , C07C2601/14
摘要: Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents —S—, —SO— or —SO2—); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.
摘要翻译: 提供能够抑制β淀粉样蛋白的产生或分泌的化合物。 由下式(1)表示的化合物:其中R 1表示可以具有取代基的杂环基,R 2表示可以具有 可以具有取代基的取代基或杂环基,R 3表示可以具有取代基的环状烃基或可以具有取代基的杂环基,R 4, 表示氢原子或C 1-6烷基,X表示-S - , - SO-或-SO 2 - )。 其N-氧化物或S-氧化物; 其盐; 或其溶剂合物; 和含有它们中任何一种的药物。
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公开(公告)号:US08785462B2
公开(公告)日:2014-07-22
申请号:US13503340
申请日:2010-10-20
申请人: Takeshi Kuribayashi , Hideki Kubota , Naoki Tanaka , Takeshi Fukuda , Takashi Tsuji , Riki Goto
发明人: Takeshi Kuribayashi , Hideki Kubota , Naoki Tanaka , Takeshi Fukuda , Takashi Tsuji , Riki Goto
IPC分类号: A61K31/505 , A61K31/40 , C07D239/02
CPC分类号: C07D401/06 , C07D401/14
摘要: The present invention provides a compound which enhances the production of erythropoietin. The present invention provides a compound represented by formula (1): [wherein, R1: formula (1A): [wherein, R4 and R5: H, halogen, or alkyl; R6: H, halogen, alkyl, or the like; R7: substitutable hydroxyalkyl, substitutable hydroxyhalo alkyl, substitutable alkoxyalkyl, or the like; substituent group α: oxo, hydroxy, amino, or the like; ring Q1: a monocyclic heterocyclic group; ring Q2: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; ring Q3: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; X: a single bond, methylene, ethylene, or the like]; R2: alkyl, or methylsulfanyl; and R3: H, or methyl], or the like.
摘要翻译: 本发明提供了促进促红细胞生成素生成的化合物。 本发明提供由式(1)表示的化合物:[其中,R1:式(1A):[其中,R4和R5:H,卤素或烷基; R6:H,卤素,烷基等; R7:可取代的羟烷基,可取代的羟基卤代烷基,可取代的烷氧基烷基等; 取代基组α:氧代,羟基,氨基等; 环Q1:单环杂环基; 环Q2:单环烃环基或单环杂环基; 环Q3:单环烃环基或单环杂环基; X:单键,亚甲基,亚乙基等); R2:烷基或甲硫基; 和R 3:H或甲基]等。
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公开(公告)号:US08314240B2
公开(公告)日:2012-11-20
申请号:US13000677
申请日:2009-06-22
申请人: Hideki Kubota , Issei Tsukamoto , Kazunori Kamijo , Koji Kato , Yuta Fukuda , Hidenori Azami
发明人: Hideki Kubota , Issei Tsukamoto , Kazunori Kamijo , Koji Kato , Yuta Fukuda , Hidenori Azami
IPC分类号: A61K31/44 , C07D213/62
CPC分类号: C07C311/21 , A61K31/341 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , C07C2602/08 , C07D213/71 , C07D213/80 , C07D277/20 , C07D277/36 , C07D277/56 , C07D307/64 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12
摘要: [Object] A compound which is useful as an EP1 receptor antagonist is provided.[Means for Solution] The present inventors investigated EP1 receptor antagonists, and confirmed that a compound having a sulfonamide structure, in which the nitrogen atom of the sulfonamide structure is substituted with 2-fluoropropyl group, 3-fluoro-2-methylpropyl group or the like, has a potent EP1 receptor antagonistic action, thereby completing the present invention. The sulfonamide compound of the present invention has a potent EP1 receptor antagonistic action and can be used as an agent for preventing and/or treating a lower urinary tract symptom or the like.
摘要翻译: 提供了可用作EP1受体拮抗剂的化合物。 [解决方案]本发明人研究了EP1受体拮抗剂,并证实了具有磺酰胺结构的化合物,其中磺酰胺结构的氮原子被2-氟丙基取代,3-氟-2-甲基丙基或 具有有效的EP1受体拮抗作用,从而完成本发明。 本发明的磺酰胺化合物具有有效的EP1受体拮抗作用,可用作预防和/或治疗下尿路症状等的药剂。
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公开(公告)号:US20110319385A1
公开(公告)日:2011-12-29
申请号:US13254368
申请日:2010-03-04
申请人: Hiroyuki Kaizawa , Mari Sugita , Hidenori Azami , Ryushi Seo , Takaho Nomura , Satoshi Yamamoto , Hirofumi Yamamoto , Kazuyuki Tsuchiya , Hideki Kubota , Kazunori Kamijo
发明人: Hiroyuki Kaizawa , Mari Sugita , Hidenori Azami , Ryushi Seo , Takaho Nomura , Satoshi Yamamoto , Hirofumi Yamamoto , Kazuyuki Tsuchiya , Hideki Kubota , Kazunori Kamijo
IPC分类号: A61K31/4985 , C07D413/14 , A61P13/00 , A61K31/5377 , A61K31/55 , C07D487/04 , C07D403/14
CPC分类号: C07D498/04 , C07D487/04 , C07D491/107 , C07D519/00
摘要: [Problem]Provided is a compound which has a PDE9-inhibiting action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like.[Means for Solution]The present inventors have investigated a compound which has a PDE9-inhibiting action and is useful as an active ingredient for an agent for treating and/or preventing storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like, and thus, have found that an imidazoquinoxaline compound or a triazoloquinoxaline compound has a PDE9-inhibiting action, thereby completing the present invention. The imidazoquinoxaline compound or the triazoloquinoxaline compound of the present invention has a PDE9-inhibiting action and can be used as an agent for preventing and/or treating storage dysfunction, voiding dysfunction, and bladder/urethral diseases, and the like.
摘要翻译: [问题]提供具有PDE9抑制作用并可用作治疗和/或预防储存功能障碍,排尿功能障碍和膀胱/尿道疾病的药剂的活性成分的化合物等。 [解决方案]本发明人已经研究了具有PDE9抑制作用并可用作治疗和/或预防储存功能障碍,排尿功能障碍和膀胱/尿道疾病等的活性成分的化合物 ,因此已经发现咪唑并喹喔啉化合物或三唑并喹喔啉化合物具有抑制PDE9的作用,从而完成了本发明。 本发明的咪唑并喹喔啉化合物或三唑并喹喔啉化合物具有PDE9抑制作用,可用作预防和/或治疗储存功能障碍,排尿功能障碍和膀胱/尿道疾病等的药剂。
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公开(公告)号:USD551167S1
公开(公告)日:2007-09-18
申请号:US29230178
申请日:2005-05-18
申请人: Hideki Kubota , Tsuyoshi Konishi
设计人: Hideki Kubota , Tsuyoshi Konishi
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