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    System and method of image processing perceptual visibility of imagery
    1.
    发明授权
    System and method of image processing perceptual visibility of imagery 有权
    图像处理感知知觉度的系统和方法

    公开(公告)号：US08705857B2

    公开(公告)日：2014-04-22

    申请号：US13572198

    申请日：2012-08-10

    申请人： Mark Alan Livingston ,  Caelan Reed Garrett

    发明人： Mark Alan Livingston ,  Caelan Reed Garrett

    IPC分类号： G06K9/00

    CPC分类号： H04N9/646

    摘要： An image processing system and method corrects the perceptual quality of an image by adjusting the image colors. “Color” in this sense is to be understood as encompassing three-dimensional parameterizations of color, incorporating both intensity and hue. These measurements are made using creative computations developed and adapted from the RETINEX™ theory (Land, 1977), where the RETINEX implementation adjusts any pixel in any direction in color space and further to automatically determine the best direction for it to be adjusted to increase the perceptual visibility of the algorithm with a minimal amount of change to the original image values.

    摘要翻译： 图像处理系统和方法通过调整图像颜色来校正图像的感知质量。 在这个意义上说，“颜色”应被理解为包含颜色的三维参数化，包括强度和色相。 这些测量是使用RETINEX™理论（Land，1977）开发和改编的创意计算进行的，其中RETINEX实现调整颜色空间中任何方向的任何像素，并进一步自动确定调整其最佳方向以增加 具有对原始图像值的最小量变化的算法的感知可见性。

    Systems and methods of discovering mixtures of models within data and probabilistic classification of data according to the model mixture
    2.
    发明授权
    Systems and methods of discovering mixtures of models within data and probabilistic classification of data according to the model mixture 失效
    根据模型混合，发现数据中的模型混合和数据概率分类的系统和方法

    公开(公告)号：US08521659B2

    公开(公告)日：2013-08-27

    申请号：US12541857

    申请日：2009-08-14

    申请人： Mark Alan Livingston ,  Aditya Maruti Palepu

    发明人： Mark Alan Livingston ,  Aditya Maruti Palepu

    IPC分类号： G06F15/18 ,  G06F1/02 ,  G06F17/10 ,  G06N7/02

    CPC分类号： G06N99/005 ,  G06K9/6226 ,  G06K9/6254

    摘要： Discovering mixtures of models includes: initiating learning algorithms, determining, data sets including a cluster of points in a first region of a domain and a set of points distributed near a first line extending across the domain; inferencing parameters from the cluster and the set of points; creating a description of the cluster of points in the first region of the domain and computing approximations of a first learned mixture model and a second learned mixture model; determining a first and second probability, generating a confidence rating that each point of the cluster of points in the first region of the domain corresponds to the first learned mixture model and generating a confidence rating that each point of the set of points distributed near the first line correspond to the second learned mixture model, thus causing determinations of behavior of a system described by the learned mixture models.

    摘要翻译： 发现模型的混合包括：启动学习算法，确定包括域的第一区域中的点集合和分布在跨域延伸的第一行附近的一组点的数据集; 从集群推导参数和集合点; 创建域的第一区域中的点集合的描述，并计算第一学习混合模型和第二学习混合模型的近似值; 确定第一和第二概率，产生置信度等级，所述域的所述第一区域中的所述聚类点的每个点对应于所述第一学习混合模型，并且生成置信度等级，所述置信区间中的每个点分布在第一 线对应于第二个学习混合模型，从而导致由所学习的混合模型描述的系统的行为的确定。

    Methods and systems of comparing face models for recognition
    3.
    发明授权
    Methods and systems of comparing face models for recognition 有权
    比较脸部模型进行识别的方法和系统

    公开(公告)号：US08477147B2

    公开(公告)日：2013-07-02

    申请号：US12416716

    申请日：2009-04-01

    申请人： Mark Alan Livingston ,  Justin M. Solomon

    发明人： Mark Alan Livingston ,  Justin M. Solomon

    IPC分类号： G09G5/00

    CPC分类号： G06K9/00275 ,  G06K9/00281 ,  G06K9/4609 ,  G06K9/469

    摘要： Methods and systems of representation and manipulation of surfaces with perceptual geometric features, using a computer graphics rendering system, include executing algorithmic instructions to compute a plurality of vertices, edges and surfaces in a mesh for the purpose of defining representations of surfaces on grids. Normals and distances are determined for triangular surfaces to be considered. Additionally, height fields of a function are defined. A set of feature curves and a set of feature points are determined, based on the defined function. Infinitesimal movements along the representations of the surfaces are determined, along with determinations of properties of representations of continuous surfaces. Additional determinations of perceptual geometric features include determinations such as zero crossings, parabolic curves, flecnodes, ruffles, gutterpoints, conical points and biflecnodes in a given mesh. After these determinations are made, visual representations are rendered which capture perceptually important features for smoothly varying shapes.

    摘要翻译： 使用计算机图形绘制系统来表示和操纵具有感知几何特征的表面的方法和系统包括执行算法指令以计算网格中的多个顶点，边缘和表面，以定义网格表面的表示。 确定要考虑的三角形表面的法线和距离。 另外，定义了一个函数的高度域。 基于定义的功能确定一组特征曲线和一组特征点。 确定沿着表面的表示的无限小的运动以及连续表面的表示的性质的确定。 感知几何特征的附加测定包括给定网格中的过零点，抛物线曲线，点阵，褶边，沟槽点，圆锥点和双点定位等确定。 在进行这些确定之后，渲染视觉表示，捕获感知重要的特征，以便平滑变化的形状。

    System and method for decoding a color image
    6.
    发明申请
    System and method for decoding a color image 审中-公开
    用于解码彩色图像的系统和方法

    公开(公告)号：US20070201741A1

    公开(公告)日：2007-08-30

    申请号：US11365631

    申请日：2006-02-28

    申请人： Alan Epshteyn ,  Alan Livingston

    发明人： Alan Epshteyn ,  Alan Livingston

    IPC分类号： G06K9/00

    CPC分类号： H04N9/64

    摘要： Described is a system and method for decoding a color image. The method comprises capturing a color image, obtaining a luminance component from the color image and decoding the luminance component.

    摘要翻译： 描述了一种用于对彩色图像进行解码的系统和方法。 该方法包括拍摄彩色图像，从彩色图像获得亮度分量并解码亮度分量。

    Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in treatment of inflammatory conditions and immune disorders
    8.
    发明授权
    Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in treatment of inflammatory conditions and immune disorders 有权
    取代的（1,3-双（环己基甲基）-1,2,3,6-四氢-2,6-二氧代-9H-嘌呤-8-基）苯基衍生物，其制备及其在治疗炎症和免疫中的应用 疾病

    公开(公告)号：US06355646B1

    公开(公告)日：2002-03-12

    申请号：US09367313

    申请日：1999-12-22

    申请人： Susan Mary Daluge ,  Gerald Wolberg ,  Douglas Alan Livingston

    发明人： Susan Mary Daluge ,  Gerald Wolberg ,  Douglas Alan Livingston

    IPC分类号： C07D47306

    CPC分类号： C07D473/06

    摘要： The present invention provides a compound of formula (I) or a solvate thereof wherein: X is —O— or —NH—; Q is (—CH2—)p, (—CH═CH—)p, (—C≡C—)p where p is an integer of from 0 to 4; R1 is hydrogen or methyl; R2 and R3 independently represent O or S n is an integer of 1 to 50; and R is hydrogen or methyl. The present invention also provides pharmaceutical compositions and methods of treatment using the compounds of formula (I). The compounds of the present invention are useful for the prophylaxis and treatment of septic shock, inflammatory conditions and immune disorders.

    摘要翻译： 本发明提供了式（I）化合物或其溶剂合物，其中：X是-O-或-NH-; Q是（-CH 2 - ）p，（-CH = CH-）p，（-C = C - ）p其中p是0至4的整数; R1是氢或甲基; R2和R3独立地表示O或Sn是1至50的整数; 和R是氢或甲基。本发明还提供了使用式（I）化合物的药物组合物和治疗方法。 本发明的化合物可用于预防和治疗败血性休克，炎性病症和免疫疾病。

    Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides
    10.
    发明授权
    Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides 失效
    用于在寡核苷酸的5'末端提供官能团的改性磷中间体

    公开(公告)号：US5874552A

    公开(公告)日：1999-02-23

    申请号：US436100

    申请日：1995-05-08

    申请人： David S. Jones ,  John P. Hachmann ,  Michael J. Conrad ,  Stephen Coutts ,  Douglas Alan Livingston

    发明人： David S. Jones ,  John P. Hachmann ,  Michael J. Conrad ,  Stephen Coutts ,  Douglas Alan Livingston

    IPC分类号： A61K39/35 ,  A61K47/48 ,  C07C323/12 ,  C07D317/20 ,  C07F9/24 ,  C07F9/655 ,  C07H21/00 ,  C07H19/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07H21/00 ,  A61K39/35 ,  A61K47/48315 ,  C07C323/12 ,  C07D317/20 ,  C07F9/2408 ,  C07F9/65515 ,  A61K2039/6093 ,  Y02P20/55

    摘要： Phosphoramidites of the formula ##STR1## where R is a base-labile protecting group, R.sup.1 and R.sup.2 are individually alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, or aryl of 6 to 20 carbon atoms or are joined together to form with the nitrogen atom a cyclic structure of 4-7 carbon atoms and 0 to 1 annular chalcogen atoms of atomic number 8 to 16, G is a hydrocarbylene group of 1 to 20 carbon atoms and Z is a hydroxy-protected vicinal diol group bound to G by one of the vicinal diol carbon atoms or a disulfide group and bound to G by one of the sulfur atoms of the disulfide group, with the proviso that G is of at least 4 carbon atoms when Z is said disulfide group are used in conventional automated oligonucleotide synthesis to introduce a functional aldehyde or thiol group on the 5' end of the oligonucleotide to thereby provide a reactive site on the oligonucleotide that may be used to conjugate the oligonucleotide to molecules that contain a free amino group or an electrophilic center reactive with a thiol group.

    摘要翻译： 其中R为碱不稳定保护基的式（ⅩⅥ）的亚磷酰胺，R 1和R 2分别为1至6个碳原子的烷基，3至8个碳原子的环烷基或6至20个碳原子的芳基或连接在一起 与氮原子一起形成原子数为8〜16的4-7个碳原子和0〜1个环状硫族原子的环状结构，G为碳原子数1〜20的亚烃基，Z为羟基保护的邻二醇基 通过邻位二醇碳原子之一或二硫键与G结合，并且通过二硫基的硫原子之一与G结合，条件是当Z是所述二硫基时，G至少为4个碳原子 在常规的自动化寡核苷酸合成中，在寡核苷酸的5'末端引入功能性醛或硫醇基团，从而在寡核苷酸上提供可用于将寡核苷酸与含有游离氨基或电离子的分子缀合的反应性位点 与硫醇基反应的中间体。