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1.发明申请CHEMICALLY-DEFINED NON-POLYMERIC VALENCY PLATFORM MOLECULES AND CONJUGATES THEREOF 审中-公开化学定义非聚合物平台分子及其结合体公开(公告)号：US20080293660A1
公开(公告)日：2008-11-27
申请号：US12100356
申请日：2008-04-09
IPC分类号： A61K31/7088 , C07K14/435 , A61P37/00 , C07H21/00
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/35 , A61K47/54 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/645 , A61K2039/6093 , C07H21/00 , C07K14/003 , Y10S514/885
摘要： Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
摘要翻译： 化学定义的非聚合物价态平台分子和缀合物，其包含化学定义的价态平台分子和生物或化学分子，包括对人类狼疮抗dsDNA自身抗体具有显着结合活性的至少20个碱基对的多核苷酸双链体。
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2.发明授权Chemically-defined non-polymeric valency platform molecules and conjugates thereof 失效化学定义的非聚合物价态平台分子及其共轭物公开(公告)号：US07115581B2
公开(公告)日：2006-10-03
申请号：US10144391
申请日：2002-05-10
IPC分类号： A61K31/7088
CPC分类号： A61K39/0008 , A61K39/35 , A61K47/54 , A61K2039/6093
摘要： Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
摘要翻译： 化学定义的非聚合物价态平台分子和缀合物，其包含化学定义的价态平台分子和生物或化学分子，包括对人类狼疮抗dsDNA自身抗体具有显着结合活性的至少20个碱基对的多核苷酸双链体。
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公开(公告)号：US5552391A
公开(公告)日：1996-09-03
申请号：US152506
申请日：1993-11-15
IPC分类号： C07H21/00 , A61K9/00 , A61K31/70 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K47/48 , A61K48/00 , A61P17/00 , A61P37/00 , A61P37/06 , C07K2/00 , C07K14/435 , C12N15/09 , A61A31/70 , C07H19/00 , C07H19/04
CPC分类号： A61K47/48192 , A61K39/0008 , A61K39/35 , A61K47/48023 , A61K47/48207 , A61K47/48215 , A61K47/48315 , C07H21/00 , C07K14/003 , A61K2039/6093 , A61K38/00 , Y10S514/885
摘要： Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
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公开(公告)号：USRE34630E
公开(公告)日：1994-06-07
申请号：US825974
申请日：1992-01-27
IPC分类号： C07D217/02 , A61K31/47 , A61K31/472 , A61P29/00 , A61P37/06 , A61P37/08 , C07D217/16 , C07D217/20 , C07D217/24 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D417/06 , C07D417/12
CPC分类号： C07D401/12 , C07D217/16 , C07D217/20 , C07D217/24 , C07D417/12
摘要： Novel substituted isoquinoline compounds are disclosed together with novel 2-phenylethylamides useful as precursors or intermediates for the production of the isoquinolines. The substituted isoquinolines exhibit activity in antagonizing the effects of platelet activating factor (PAF).
摘要翻译： 公开了新颖的取代的异喹啉化合物以及用作制备异喹啉的前体或中间体的新的2-苯基乙酰胺。 取代的异喹啉表现出拮抗血小板活化因子（PAF）的作用。
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公开(公告)号：US4477446A
公开(公告)日：1984-10-16
申请号：US509616
申请日：1983-07-01
申请人： Howard Jones , Stephen M. Coutts
发明人： Howard Jones , Stephen M. Coutts
IPC分类号： C07D233/16 , A61K31/55 , A61P37/08 , C07D223/16
CPC分类号： C07D223/16
摘要： Pharmaceutical compositions comprising 1-benzazepinediones of the formula: ##STR1## wherein: X and Y are independently O, S, NR or CH-R;A and B are independently H, halo, OH, OR, CF.sub.3 or R; andR is H, lower alkyl, aryl, aralkyl or aminoalkyl, are useful as antiallergic agents.
摘要翻译： 药物组合物，其包含下式的1-苯并吖庚因：其中：X和Y独立地为O，S，NR或CH-R; A和B独立地为H，卤素，OH，OR，CF 3或R; 并且R是H，低级烷基，芳基，芳烷基或氨基烷基，可用作抗过敏剂。
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公开(公告)号：US06060056A
公开(公告)日：2000-05-09
申请号：US118055
申请日：1993-09-08
IPC分类号： A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/385 , A61K47/48 , A61P37/04 , A61P37/06 , C07K7/06 , C07K14/76 , C07K16/00 , C07K17/00
CPC分类号： A61K39/0008 , A61K39/35 , A61K47/48023 , A61K2039/6093 , A61K38/00 , Y10S424/81 , Y10S530/868
摘要： Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
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7.发明授权Chemically defined non-polymeric valency platform molecules and conjugates thereof 失效化学上定义的非聚合物价态平台分子及其共轭物公开(公告)号：US07351855B2
公开(公告)日：2008-04-01
申请号：US10631388
申请日：2003-07-30
IPC分类号： C07K53/126 , A61K31/70
CPC分类号： A61K39/0008 , A61K39/35 , A61K47/54 , A61K2039/6093
摘要： Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
摘要翻译： 化学定义的非聚合物价态平台分子和缀合物，其包含化学定义的价态平台分子和生物或化学分子，包括对人类狼疮抗dsDNA自身抗体具有显着结合活性的至少20个碱基对的多核苷酸双链体。
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8.发明授权Chemically-defined non-polymeric valency platform molecules and conjugates thereof 失效化学定义的非聚合物价态平台分子及其共轭物
公开(公告)号：US5633395A
公开(公告)日：1997-05-27
申请号：US453452
申请日：1995-05-30
IPC分类号： C07H21/00 , A61K9/00 , A61K31/70 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K47/48 , A61K48/00 , A61P17/00 , A61P37/00 , A61P37/06 , C07K2/00 , C07K14/435 , C12N15/09 , C07F9/02
CPC分类号： A61K47/48192 , A61K39/0008 , A61K39/35 , A61K47/48023 , A61K47/48207 , A61K47/48215 , A61K47/48315 , C07H21/00 , C07K14/003 , A61K2039/6093 , A61K38/00 , Y10S514/885
摘要： Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
摘要翻译： 化学定义的非聚合物价态平台分子和缀合物，其包含化学定义的价态平台分子和生物或化学分子，包括对人类狼疮抗dsDNA自身抗体具有显着结合活性的至少20个碱基对的多核苷酸双链体。
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公开(公告)号：US5606047A
公开(公告)日：1997-02-25
申请号：US453254
申请日：1995-05-30
IPC分类号： C07H21/00 , A61K9/00 , A61K31/70 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K47/48 , A61K48/00 , A61P17/00 , A61P37/00 , A61P37/06 , C07K2/00 , C07K14/435 , C12N15/09 , C07H19/04
CPC分类号： A61K47/48192 , A61K39/0008 , A61K39/35 , A61K47/48023 , A61K47/48207 , A61K47/48215 , A61K47/48315 , C07H21/00 , C07K14/003 , A61K2039/6093 , A61K38/00 , Y10S514/885
摘要： Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
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公开(公告)号：US5019573A
公开(公告)日：1991-05-28
申请号：US409630
申请日：1989-09-19
IPC分类号： A61K31/34 , A61K31/343 , A61K31/40 , A61K31/535 , A61P11/00 , A61P29/00 , A61P37/06 , A61P37/08 , C07D307/91 , C07D405/12
CPC分类号： C07D307/91
摘要： Novel substituted dibenzofuran compounds are disclosed. The compounds exhibit activity in antagonizing the effects of leukotriene B.sub.4 (LTB.sub.4). Pharmaceutical compositions containing the novel compounds and methods of treatment employing the same are also described.
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