公开(公告)号：US5342976A

公开(公告)日：1994-08-30

申请号：US966771

申请日：1992-10-27

Applicant: Paul A. Bowser ,  Albert Froling ,  Lammert Heslinga ,  Udo M. T. Houtsmuller ,  Diederik H. Nugteren ,  Hendrik J. J. Pabon ,  Colin Prottey

Inventor： Paul A. Bowser ,  Albert Froling ,  Lammert Heslinga ,  Udo M. T. Houtsmuller ,  Diederik H. Nugteren ,  Hendrik J. J. Pabon ,  Colin Prottey

IPC: C07C59/42 ,  C07H13/06 ,  C07G11/00 ,  C09F7/00 ,  C11C3/00

CPC classification number: A61K8/37 ,  A61K8/68 ,  A61Q17/00 ,  C07C59/42 ,  C07H13/06

Abstract: A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy-or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.

Abstract translation: 适合于局部施用于人皮肤的组合物除了合适的载体之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。

公开(公告)号：US4950688A

公开(公告)日：1990-08-21

申请号：US505005

申请日：1983-06-16

Applicant: Paul A. Bowser ,  Albert Froling ,  Lammert Heslinga ,  Udo M. T. Houtsmuller ,  Diederik H. Nugteren ,  Hendrik J. J. Pabon ,  Colin Prottey

Inventor： Paul A. Bowser ,  Albert Froling ,  Lammert Heslinga ,  Udo M. T. Houtsmuller ,  Diederik H. Nugteren ,  Hendrik J. J. Pabon ,  Colin Prottey

IPC: A61K31/23 ,  C07C59/42 ,  C07C69/527 ,  C07H13/06

CPC classification number: A61K8/37 ,  A61K8/68 ,  A61Q17/00 ,  C07C59/42 ,  C07H13/06 ,  Y10S424/05 ,  Y10S514/873 ,  Y10S514/887 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/944 ,  Y10S514/949 ,  Y10S514/969

Abstract: A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle and a perfume, an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy- or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.

Abstract translation: 适合于皮肤外用于人体皮肤的组合物除了合适的载体和香料之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。

公开(公告)号：US5202357A

公开(公告)日：1993-04-13

申请号：US541993

申请日：1990-06-21

Applicant: Paul A. Bowser ,  Albert Froling ,  Lammert Heslinga ,  Udo M. T. Houtsmuller ,  Diederik H. Nugteren ,  Hendrik J. J. Pabon ,  Colin Prottey

Inventor： Paul A. Bowser ,  Albert Froling ,  Lammert Heslinga ,  Udo M. T. Houtsmuller ,  Diederik H. Nugteren ,  Hendrik J. J. Pabon ,  Colin Prottey

IPC: C07C59/42 ,  C07H13/06

CPC classification number: A61K8/37 ,  A61K8/68 ,  A61Q17/00 ,  C07C59/42 ,  C07H13/06 ,  Y10S424/05 ,  Y10S514/873 ,  Y10S514/887 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/944 ,  Y10S514/949 ,  Y10S514/969

Abstract: A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy- or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.

Abstract translation: 适合于局部施用于人皮肤的组合物除了合适的载体之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。

公开(公告)号：US4399007A

公开(公告)日：1983-08-16

申请号：US274578

申请日：1981-06-17

Applicant: Albert Froling ,  Rudolph O. de Jongh ,  Josephus M. A. Kemps

Inventor： Albert Froling ,  Rudolph O. de Jongh ,  Josephus M. A. Kemps

IPC: C25B3/04 ,  C07B31/00 ,  C07B35/02 ,  C07C67/00 ,  C11C3/12

CPC classification number: C25B3/04 ,  C11C3/12

Abstract: Process for the selective hydrogenation of polyunsaturated compounds with a metallic catalyst. The selectivity is increased and trans-isomerization is decreased by carrying out the hydrogenation in the presence of a catalyst to which, before the hydrogenation is started, an external potential, differing from the naturally occuring equilibrium potential, is applied while in contact with an electrolyte, such as a quaternary ammonium salt, dissolved in a liquid, such as an alcohol or a ketone.

公开(公告)号：US4326932A

公开(公告)日：1982-04-27

申请号：US2048

申请日：1979-01-08

Applicant: Albert Froling ,  Rudolph O. de Jongh ,  Josephus M. A. Kemps

Inventor： Albert Froling ,  Rudolph O. de Jongh ,  Josephus M. A. Kemps

IPC: C25B3/04 ,  C07B31/00 ,  C07B35/02 ,  C07C67/00 ,  C11C3/12

CPC classification number: C25B3/04 ,  C11C3/12

Abstract: Process for the selective hydrogenation of polyunsaturated compounds with a metallic catalyst. The selectivity is increased and trans-isomerization is decreased by carrying out the hydrogenation in the presence of a catalyst to which, before the hydrogenation is started, an external potential, differing from the naturally occuring equilibrium potential, is applied while in contact with an electrolyte, such as a quaternary ammonium salt, dissolved in a liquid, such as an alcohol or a ketone.

Abstract translation: 用金属催化剂选择性氢化多不饱和化合物的方法。 通过在催化剂的存在下进行氢化来降低选择性，并且在氢化开始之前，在与电解质接触的同时施加与天然存在的平衡电位不同的外部电位， ，例如溶解在液体中的季铵盐，例如醇或酮。