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公开(公告)号：US4507319A
公开(公告)日：1985-03-26
申请号：US462641
申请日：1983-01-31
申请人： Martin D. Barratt , Paul A. Bowser , James A. Durrant , Dieno George , Keith J. Hall , John C. Hill , Michael R. Lowry , Colin Prottey
发明人： Martin D. Barratt , Paul A. Bowser , James A. Durrant , Dieno George , Keith J. Hall , John C. Hill , Michael R. Lowry , Colin Prottey
IPC分类号： A61K8/365 , A61K31/045 , A61K31/13 , A61K31/19 , A61K31/20 , A61K31/21 , A61K31/22 , A61K31/35 , A61Q19/00 , C07C59/01 , C07C59/185
CPC分类号： A61Q19/007 , A61K8/365 , A61Q19/00
摘要： A cosmetically acceptable composition for topical application to human skin comprises from 0.1 to 20% by weight of a substituted 2-hydroxyoctanoic acid or 2-ketooctanoic acid or a mixture thereof, together with an amount of a special neutralizing agent sufficient to adjust the pH of the composition to a value of from 3 to 7. The special neutralizing agent is one having a cation whose ionic radius is at least 100 pm.
摘要翻译： 用于局部施用于人皮肤的美容上可接受的组合物包含0.1至20重量％的取代的2-羟基辛酸或2-酮辛酸或其混合物，以及足以调节pH值的特定中和剂的量 该组合物的值为3至7.特殊中和剂是具有离子半径至少为100μm的阳离子。
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公开(公告)号：US4950688A
公开(公告)日：1990-08-21
申请号：US505005
申请日：1983-06-16
申请人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
发明人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
IPC分类号： A61K31/23 , C07C59/42 , C07C69/527 , C07H13/06
CPC分类号： A61K8/37 , A61K8/68 , A61Q17/00 , C07C59/42 , C07H13/06 , Y10S424/05 , Y10S514/873 , Y10S514/887 , Y10S514/937 , Y10S514/938 , Y10S514/944 , Y10S514/949 , Y10S514/969
摘要： A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle and a perfume, an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy- or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.
摘要翻译： 适合于皮肤外用于人体皮肤的组合物除了合适的载体和香料之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。
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公开(公告)号：US4612331A
公开(公告)日：1986-09-16
申请号：US688948
申请日：1985-01-04
申请人： Martin D. Barratt , Paul A. Bowser , James A. Durrant , Dieno George , Keith J. Hall , John C. Hill , Michael R. Lowry , Colin Prottey
发明人： Martin D. Barratt , Paul A. Bowser , James A. Durrant , Dieno George , Keith J. Hall , John C. Hill , Michael R. Lowry , Colin Prottey
IPC分类号： A61K8/365 , A61K31/045 , A61K31/13 , A61K31/19 , A61K31/20 , A61K31/21 , A61K31/22 , A61K31/35 , A61Q19/00 , C07C59/01 , C07C59/185
CPC分类号： A61Q19/007 , A61K8/365 , A61Q19/00
摘要： A cosmetically acceptable composition for topical application to human skin comprises from 0.1 to 20% by weight of a substituted 2-hydroxyoctanoic acid or 2-ketooctanoic acid or a mixture thereof, together with an amount of a special neutralizing agent sufficient to adjust the pH of the composition to a value of from 3 to 7. The special neutralizing agent is one having a cation whose ionic radius is at least 100 pm.
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公开(公告)号：US6129243A
公开(公告)日：2000-10-10
申请号：US733034
申请日：1996-10-16
CPC分类号： B65D35/242 , B65D35/22
摘要： The invention relates to an adaptor which enables two premade tubes such as toothpaste tubes of varying sizes to be fitted together, one inside the other to obtain a dual tube dispenser providing for separate storage of two dissimilar substances and its co-extrusion from the dispenser as and when desired upon application of external pressure on the latter. The adaptor includes a threaded component in the form of a cap with internal threads to match the threads of the neck portion of conventional toothpaste tubes. A central passage provided in the adaptor communicates with the inside of the tube to which it is screw-fitted. The adaptor is further provided with press-fitting studs to hold the tube coaxially within a larger tube to obtain a dual tube dispenser, the press-fitting studs being capable of forming a press-fit connection in the internal portion of the neck of the larger tube.
摘要翻译： 本发明涉及一种适配器，其使得两个预制管例如不同尺寸的牙膏管能够装配在一起，一个在另一个内部，以获得双管分配器，其提供两个不同物质的单独存储和其与分配器的共挤出作为 并且当在后者上施加外部压力时需要。 适配器包括具有内螺纹形式的螺纹部件，以与传统牙膏管的颈部部分的螺纹相匹配。 设置在适配器中的中央通道与其螺旋配合的管的内部连通。 适配器还设置有压配螺柱以将管同轴地保持在更大的管中以获得双管分配器，压配螺柱能够在较大的颈部的颈部的内部部分中形成压配合连接 管。
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公开(公告)号：US5202357A
公开(公告)日：1993-04-13
申请号：US541993
申请日：1990-06-21
申请人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
发明人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
CPC分类号： A61K8/37 , A61K8/68 , A61Q17/00 , C07C59/42 , C07H13/06 , Y10S424/05 , Y10S514/873 , Y10S514/887 , Y10S514/937 , Y10S514/938 , Y10S514/944 , Y10S514/949 , Y10S514/969
摘要： A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy- or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.
摘要翻译： 适合于局部施用于人皮肤的组合物除了合适的载体之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。
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公开(公告)号：US5342976A
公开(公告)日：1994-08-30
申请号：US966771
申请日：1992-10-27
申请人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
发明人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
摘要： A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy-or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.
摘要翻译： 适合于局部施用于人皮肤的组合物除了合适的载体之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。
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