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公开(公告)号：US5342976A
公开(公告)日：1994-08-30
申请号：US966771
申请日：1992-10-27
申请人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
发明人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
摘要： A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy-or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.
摘要翻译： 适合于局部施用于人皮肤的组合物除了合适的载体之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。
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公开(公告)号：US4950688A
公开(公告)日：1990-08-21
申请号：US505005
申请日：1983-06-16
申请人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
发明人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
IPC分类号： A61K31/23 , C07C59/42 , C07C69/527 , C07H13/06
CPC分类号： A61K8/37 , A61K8/68 , A61Q17/00 , C07C59/42 , C07H13/06 , Y10S424/05 , Y10S514/873 , Y10S514/887 , Y10S514/937 , Y10S514/938 , Y10S514/944 , Y10S514/949 , Y10S514/969
摘要： A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle and a perfume, an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy- or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.
摘要翻译： 适合于皮肤外用于人体皮肤的组合物除了合适的载体和香料之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。
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公开(公告)号：US4163108A
公开(公告)日：1979-07-31
申请号：US343269
申请日：1973-03-21
IPC分类号： C07C51/09 , C07C51/353 , C07C51/36 , C07C57/66 , C07C405/00 , C12P31/00
CPC分类号： C12P31/00 , C07C405/00 , C07C51/09 , C07C51/353 , C07C51/36 , C07C57/66
摘要： .omega.-Nor and .omega.-homo prostaglandins E having blood platelet aggregation-inhibiting activity are prepared by enzymatic synthesis fron nonadeca- and henicosa- -8c, 11c,14c-trienoic acids.
摘要翻译： 具有血小板聚集抑制活性的ω-ω和ω-oo前列腺素E通过非甾体和异烟酸-8c，11c，14c-三烯酸的酶促合成制备。
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公开(公告)号：US5202357A
公开(公告)日：1993-04-13
申请号：US541993
申请日：1990-06-21
申请人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
发明人： Paul A. Bowser , Albert Froling , Lammert Heslinga , Udo M. T. Houtsmuller , Diederik H. Nugteren , Hendrik J. J. Pabon , Colin Prottey
CPC分类号： A61K8/37 , A61K8/68 , A61Q17/00 , C07C59/42 , C07H13/06 , Y10S424/05 , Y10S514/873 , Y10S514/887 , Y10S514/937 , Y10S514/938 , Y10S514/944 , Y10S514/949 , Y10S514/969
摘要： A composition suitable for topical application to human skin comprises, in addition to a suitable vehicle an active ingredient which can control skin barrier functions. The active ingredient is (a) a long chain .omega.-hydroxy fatty acid or a carboxy-substituted derivative, (b) an hydroxy- or epoxy-derivative of an essential fatty acid or an ester formed between (a) and (b). Certain novel compounds of structures (a), (b) and (a)(b) esters are also claimed.
摘要翻译： 适合于局部施用于人皮肤的组合物除了合适的载体之外还包含可以控制皮肤屏障功能的活性成分。 活性成分是（a）长链ω-羟基脂肪酸或羧基取代的衍生物，（b）必需脂肪酸的羟基或环氧衍生物或（a）和（b）之间形成的酯。 还要求一些结构（a），（b）和（a）（b）酯的新颖化合物。
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