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    BIOPOLYMERIC GERMPLASM INTEGUMENTS
    3.
    发明申请
    BIOPOLYMERIC GERMPLASM INTEGUMENTS 审中-公开

    公开(公告)号：US20190261627A1

    公开(公告)日：2019-08-29

    申请号：US16285359

    申请日：2019-02-26

    申请人： Aleo BME, Inc.

    发明人： John Round ,  Duygu Ercan Oruc ,  Chao Liu

    IPC分类号： A01N25/24 ,  A01N25/10 ,  C08G63/685 ,  C05B17/00

    摘要： A germplasm growth inducing composition comprises a biodegradable polymer or oligomer; and a plant bioactive component. The biodegradable polymer can comprise a citrate polymer in some embodiments, the citrate polymer being formed from one or more monomers of citric acid, one or more monomers of a C2-C14 polyol. A method of inducing germplasm growth comprises applying the germplasm growth inducing composition to a plant germplasm as an integument or applying the germplasm growth inducing composition to soil as a soil amendment.

    Compositions comprising fluid gels for tissue separation
    4.
    发明授权
    Compositions comprising fluid gels for tissue separation 有权

    公开(公告)号：US12090243B2

    公开(公告)日：2024-09-17

    申请号：US17211037

    申请日：2021-03-24

    申请人： ALEO BME, INC.

    发明人： Chao Liu ,  Chuying Ma ,  Xuedi Yu

    IPC分类号： A61L24/00 ,  A61L24/04 ,  A61L27/26 ,  A61L27/52

    CPC分类号： A61L24/0031 ,  A61L24/043 ,  A61L27/26 ,  A61L27/52 ,  A61L2300/442 ,  A61L2300/802 ,  A61L2400/04 ,  A61L2400/06

    摘要： The present disclosure is directed to an injectable composition in form of fluid gel and the use thereof to assist the tissues resection during endoscopic procedures in which it is injected in the tissue of interest to form a cushion for tissue separation. Aspects of the composition can include a gelling agent, a modifier, a salt and water. The composition can be prepared by mixing the gelling agent, modifier, at least one salt and water via continuous stirring to obtain fluid gel solutions, wherein modifier enables the said fluid gel composition to be injected into the submucosal layer of gastrointestinal tissues through endoscopic injection catheter and needle with significantly reduced injection pressure and generate a high and durable cushion for long-lasting tissue raise-up in the submucosal layer, for the application of injection assisted resection procedures.

    COMPOSITIONS COMPRISING FLUID GELS FOR TISSUE SEPARATION
    6.
    发明申请
    COMPOSITIONS COMPRISING FLUID GELS FOR TISSUE SEPARATION 有权

    公开(公告)号：US20220305171A1

    公开(公告)日：2022-09-29

    申请号：US17211037

    申请日：2021-03-24

    申请人： ALEO BME, INC.

    发明人： Chao Liu ,  Chuying Ma ,  Xuedi Yu

    IPC分类号： A61L24/00 ,  A61L24/04 ,  A61L27/52 ,  A61L27/26

    摘要： The present disclosure is directed to an injectable composition in form of fluid gel and the use thereof to assist the tissues resection during endoscopic procedures in which it is injected in the tissue of interest to form a cushion for tissue separation. Aspects of the composition can include a gelling agent, a modifier, a salt and water. The composition can be prepared by mixing the gelling agent, modifier, at least one salt and water via continuous stirring to obtain fluid gel solutions, wherein modifier enables the said fluid gel composition to be injected into the submucosal layer of gastrointestinal tissues through endoscopic injection catheter and needle with significantly reduced injection pressure and generate a high and durable cushion for long-lasting tissue raise-up in the submucosal layer, for the application of injection assisted resection procedures.

    COMPOSITIONS AND METHODS OF MAKING A THIN FILM AND APPLICATIONS THEREOF
    7.
    发明申请
    COMPOSITIONS AND METHODS OF MAKING A THIN FILM AND APPLICATIONS THEREOF 有权

    公开(公告)号：US20210363381A1

    公开(公告)日：2021-11-25

    申请号：US17040253

    申请日：2019-03-14

    申请人： ALEO BME, INC.

    发明人： Chao LIU ,  John J. ROUND

    IPC分类号： C09D175/06 ,  C08G18/75 ,  C08G18/42 ,  C08G18/10 ,  C08G18/48 ,  C08G18/40 ,  A61L26/00

    摘要： In some embodiments, a film forming composition described herein comprises an aliphatic polyisocyanate; an aliphatic polyfunctional nucleophile; a chain extender; a first solvent; and a second solvent, wherein an evaporation rate of the first solvent and an evaporation rate of the second solvent are within 150% of each other, the percentage being based on the larger value. In some embodiments, a method of forming a film on a substrate is described herein, the method comprising combining a polyisocyanate with a polyol to form a polyurethane pre-polymer; combining the polyurethane pre-polymer with a chain extender to form a polymer; and applying the polymer to the substrate.

    WATER-BASED TISSUE ADHESIVES
    8.
    发明申请
    WATER-BASED TISSUE ADHESIVES 审中-公开

    公开(公告)号：US20200254136A1

    公开(公告)日：2020-08-13

    申请号：US16652944

    申请日：2018-10-01

    申请人： ALEO BME, Inc.

    发明人： Chao LIU ,  Jinshan GUO ,  Chen CHEN ,  John Jay ROUND ,  Wei SONG

    IPC分类号： A61L15/58 ,  C09J201/00

    摘要： An adhesive composition described herein comprises an aqueous solvent; and a population of first nanoparticles dispersed in the aqueous solvent, the first nanoparticles comprising a negative or positive charge, and an average size in three dimensions of 1 nm to 1000 nm. In some embodiments, a population of second nanoparticles is dispersed in the aqueous solvent, the second nanoparticles comprises a negative or positive charge opposite the charge of the population of first nanoparticles. In some embodiments, the population of first nanoparticles comprise an average first size in three dimensions, and the population of second nanoparticles comprise an average second size in three dimensions that is different from the average first size of the first nanoparticles.