MOLECULAR TARGET OF NEUROTOXICITY
    2.
    发明申请
    MOLECULAR TARGET OF NEUROTOXICITY 审中-公开
    分子靶向的神经毒性

    公开(公告)号:US20120202846A1

    公开(公告)日:2012-08-09

    申请号:US13432484

    申请日:2012-03-28

    摘要: The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterisation and/or treatment (or management) of neurodegenerative diseases, particularly amyotrophic lateral sclerosis. The invention equally concerns methods for identifying or screening compounds active in these diseases. The invention further concerns the compounds, genes, cells, plasmids or compositions useful for implementing the hereinabove methods. In particular, the invention describes the role of PDE4B in these diseases and its use as a therapeutic, diagnostic or experimental target.

    摘要翻译: 本发明涉及生物学,遗传学和医学领域。 特别地,它涉及神经变性疾病,特别是肌萎缩性侧索硬化症的检测,表征和/或治疗(或治疗)的新方法。 本发明同样涉及用于鉴定或筛选在这些疾病中活跃的化合物的方法。 本发明还涉及可用于实施上述方法的化合物,基因,细胞,质粒或组合物。 特别地,本发明描述了PDE4B在这些疾病中的作用及其作为治疗,诊断或实验目标的用途。

    MOLECULAR TARGET OF NEUROTOXICITY
    3.
    发明申请
    MOLECULAR TARGET OF NEUROTOXICITY 审中-公开
    分子靶向的神经毒性

    公开(公告)号:US20100204251A1

    公开(公告)日:2010-08-12

    申请号:US12628561

    申请日:2009-12-01

    摘要: The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterisation and/or treatment (or management) of neurodegenerative diseases, particularly amyotrophic lateral sclerosis. The invention equally concerns methods for identifying or screening compounds active in these diseases. The invention further concerns the compounds, genes, cells, plasmids or compositions useful for implementing the hereinabove methods. In particular, the invention describes the role of PDE4B in these diseases and its use as a therapeutic, diagnostic or experimental target.

    摘要翻译: 本发明涉及生物学,遗传学和医学领域。 特别地,它涉及用于神经变性疾病,特别是肌萎缩性侧索硬化症的检测,表征和/或治疗(或治疗)的新方法。 本发明同样涉及用于鉴定或筛选在这些疾病中活跃的化合物的方法。 本发明还涉及可用于实施上述方法的化合物,基因,细胞,质粒或组合物。 特别地,本发明描述了PDE4B在这些疾病中的作用及其作为治疗,诊断或实验目标的用途。