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8 条记录 (耗时 0.018 秒)

    MOLECULAR TARGET OF NEUROTOXICITY
    2.
    发明申请
    MOLECULAR TARGET OF NEUROTOXICITY 审中-公开
    分子靶向的神经毒性

    公开(公告)号：US20120202846A1

    公开(公告)日：2012-08-09

    申请号：US13432484

    申请日：2012-03-28

    申请人： Ali AIT IKHLEF ,  Annelies Resink ,  Fabien Schweighoffer

    发明人： Ali AIT IKHLEF ,  Annelies Resink ,  Fabien Schweighoffer

    IPC分类号： A61K31/437 ,  A61P25/16 ,  A61P9/10 ,  A61P25/28

    CPC分类号： A61K31/00 ,  C12Q1/44 ,  C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterisation and/or treatment (or management) of neurodegenerative diseases, particularly amyotrophic lateral sclerosis. The invention equally concerns methods for identifying or screening compounds active in these diseases. The invention further concerns the compounds, genes, cells, plasmids or compositions useful for implementing the hereinabove methods. In particular, the invention describes the role of PDE4B in these diseases and its use as a therapeutic, diagnostic or experimental target.

    摘要翻译： 本发明涉及生物学，遗传学和医学领域。 特别地，它涉及神经变性疾病，特别是肌萎缩性侧索硬化症的检测，表征和/或治疗（或治疗）的新方法。 本发明同样涉及用于鉴定或筛选在这些疾病中活跃的化合物的方法。 本发明还涉及可用于实施上述方法的化合物，基因，细胞，质粒或组合物。 特别地，本发明描述了PDE4B在这些疾病中的作用及其作为治疗，诊断或实验目标的用途。

    MOLECULAR TARGET OF NEUROTOXICITY
    3.
    发明申请
    MOLECULAR TARGET OF NEUROTOXICITY 审中-公开
    分子靶向的神经毒性

    公开(公告)号：US20100204251A1

    公开(公告)日：2010-08-12

    申请号：US12628561

    申请日：2009-12-01

    申请人： Ali AIT IKHLEF ,  Annelies Resink ,  Fabien Schweighoffer

    发明人： Ali AIT IKHLEF ,  Annelies Resink ,  Fabien Schweighoffer

    IPC分类号： A61K31/522 ,  A61K31/437 ,  A61P25/16 ,  A61P25/28

    CPC分类号： A61K31/00 ,  C12Q1/44 ,  C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterisation and/or treatment (or management) of neurodegenerative diseases, particularly amyotrophic lateral sclerosis. The invention equally concerns methods for identifying or screening compounds active in these diseases. The invention further concerns the compounds, genes, cells, plasmids or compositions useful for implementing the hereinabove methods. In particular, the invention describes the role of PDE4B in these diseases and its use as a therapeutic, diagnostic or experimental target.

    摘要翻译： 本发明涉及生物学，遗传学和医学领域。 特别地，它涉及用于神经变性疾病，特别是肌萎缩性侧索硬化症的检测，表征和/或治疗（或治疗）的新方法。 本发明同样涉及用于鉴定或筛选在这些疾病中活跃的化合物的方法。 本发明还涉及可用于实施上述方法的化合物，基因，细胞，质粒或组合物。 特别地，本发明描述了PDE4B在这些疾病中的作用及其作为治疗，诊断或实验目标的用途。

    Methods involving PDE4, compositions, and the screening thereof, for the treatment of degenerative ocular pathologies
    4.
    发明授权
    Methods involving PDE4, compositions, and the screening thereof, for the treatment of degenerative ocular pathologies 失效
    涉及PDE4，组合物及其筛选的方法用于治疗退行性眼病

    公开(公告)号：US07872015B2

    公开(公告)日：2011-01-18

    申请号：US10541503

    申请日：2004-02-18

    申请人： Fabien Schweighoffer ,  Annelies Resink ,  Laurent Desire ,  Magali Rouquette

    发明人： Fabien Schweighoffer ,  Annelies Resink ,  Laurent Desire ,  Magali Rouquette

    IPC分类号： A01N43/42 ,  A01N43/40 ,  A01N43/56 ,  A61K31/44 ,  A61K31/415

    CPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/706

    摘要： The invention relates to the field of biology, genetics and medicine. In particular, the invention relates to novel methods for the detection, characterization and/or treatment (or management) of neurodegenerative pathologies. The invention also relates to methods for the identification or screening of compounds active in the aforementioned pathologies. The invention further relates to the compounds, genes, cells, plasmids or compositions which are used to carry out said methods. In particular, the invention is based on the identification of the role of phosphodiesterase 4B, the peripheral benzodiazepine receptor (PBR) and GABA receptors of the type GABA(A) in neurodegenerative pathologies and describes the use of same as therapeutic, diagnostic or experimental markers or targets for said disorders.

    摘要翻译： 本发明涉及生物学，遗传学和医学领域。 特别地，本发明涉及神经变性病理学的检测，表征和/或治疗（或治疗）的新方法。 本发明还涉及用于鉴定或筛选在上述病症中活性的化合物的方法。 本发明还涉及用于实施所述方法的化合物，基因，细胞，质粒或组合物。 特别地，本发明基于在神经变性病理学中鉴定磷酸二酯酶4B，外周苯并二氮杂受体（PBR）和GABA（A）类型的GABA受体的作用，并描述了其用于治疗，诊断或实验标记 或所述疾病的靶标。

    Method involving pde4, compositions, and the screening thereof, for the treatment of degenerative ocular pathologies
    5.
    发明申请
    Method involving pde4, compositions, and the screening thereof, for the treatment of degenerative ocular pathologies 失效
    涉及pde4，组合物及其筛选的方法，用于治疗退行性眼病

    公开(公告)号：US20060241062A1

    公开(公告)日：2006-10-26

    申请号：US10541503

    申请日：2004-02-18

    申请人： Fabien Schweighoffer ,  Annelies Resink ,  Laurent Desire ,  Magali Rouquette

    发明人： Fabien Schweighoffer ,  Annelies Resink ,  Laurent Desire ,  Magali Rouquette

    IPC分类号： A61K31/7056 ,  A61K31/4745

    CPC分类号： A61K31/437 ,  A61K31/444 ,  A61K31/706

    摘要： The invention relates to the field of biology, genetics and medicine. In particular, the invention relates to novel methods for the detection, characterization and/or treatment (or management) of neurodegenerative pathologies. The invention also relates to methods for the identification or screening of compounds active in the aforementioned pathologies. The invention further relates to the compounds, genes, cells, plasmids or compositions which are used to carry out said methods. In particular, the invention is based on the identification of the role of phosphodiesterase 4B, the peripheral benzodiazepine receptor (PBR) and GABA receptors of the type GABA(A) in neurodegenerative pathologies and describes the use of same as therapeutic, diagnostic or experimental markers or targets for said disorders.

    摘要翻译： 本发明涉及生物学，遗传学和医学领域。 特别地，本发明涉及神经变性病理学的检测，表征和/或治疗（或治疗）的新方法。 本发明还涉及用于鉴定或筛选在上述病理学中有活性的化合物的方法。 本发明还涉及用于实施所述方法的化合物，基因，细胞，质粒或组合物。 特别地，本发明基于在神经变性病理学中鉴定磷酸二酯酶4B，外周苯并二氮杂受体（PBR）和GABA（A）类型的GABA受体的作用，并描述了其用于治疗，诊断或实验标记 或所述疾病的靶标。

    Histone deacetylase: novel molecular target of neurotoxicity
    6.
    发明申请
    Histone deacetylase: novel molecular target of neurotoxicity 审中-公开
    组蛋白脱乙酰酶：新型分子靶点的神经毒性

    公开(公告)号：US20050009030A1

    公开(公告)日：2005-01-13

    申请号：US10502754

    申请日：2003-03-25

    申请人： Fabien Schweighoffer ,  Annelies Resink

    发明人： Fabien Schweighoffer ,  Annelies Resink

    IPC分类号： G01N33/50 ,  A61K31/00 ,  A61K31/7088 ,  A61P25/00 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/34 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

    CPC分类号： A61K31/00 ,  A61K31/7088 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention concerns the field of biology, genetics and medicine. It particularly pertains to new methods for detecting, characterising and/or treating neurodegenerative diseases, particularly amyotrophic lateral sclerosis. The invention also pertains to methods for identifying or screening for compounds active in these diseases. The invention also relates to the compounds, genes, cells, plasmids or compositions useful for implementing said methods. The invention particularly describes the role of the histone deacetylases, and particularly histone deacetylase 2, in these diseases and its use as a therapeutic, diagnostic or experimental target.

    摘要翻译： 本发明涉及生物学，遗传学和医学领域。 它特别涉及用于检测，表征和/或治疗神经变性疾病，特别是肌萎缩性侧索硬化的新方法。 本发明还涉及鉴定或筛选这些疾病中活性物质的方法。 本发明还涉及可用于实施所述方法的化合物，基因，细胞，质粒或组合物。 本发明特别描述了组蛋白脱乙酰酶，特别是组蛋白脱乙酰酶2在这些疾病中的作用及其作为治疗，诊断或实验目标的用途。

    Use of pyrazolopyridines for the treatment of cognitive deficits
    7.
    发明申请
    Use of pyrazolopyridines for the treatment of cognitive deficits 审中-公开
    使用吡唑并吡啶治疗认知缺陷

    公开(公告)号：US20060142326A1

    公开(公告)日：2006-06-29

    申请号：US10560774

    申请日：2004-06-25

    申请人： Fabien Schweighoffer ,  Laurent Desire ,  Annelies Resink ,  Magali Rouquette

    发明人： Fabien Schweighoffer ,  Laurent Desire ,  Annelies Resink ,  Magali Rouquette

    IPC分类号： A61K31/4745

    CPC分类号： A61K31/437

    摘要： The invention relates to methods which are used to improve, increase or facilitate the cognition of individuals with neurodegenerative pathologies. More specifically, the invention relates to the use of compounds from the family of pyrazolopyridines in order to improve the cognitive faculties of individuals with neurodegenerative diseases. The invention can be used to improve the condition of individuals with different neurodegenerative diseases and, in particular, Alzheimer's disease and vascular dementia.

    摘要翻译： 本发明涉及用于改善，增加或促进具有神经变性病理学的个体认知的方法。 更具体地，本发明涉及使用吡唑并吡啶酮类化合物，以改善具有神经变性疾病的个体的认知能力。 本发明可用于改善具有不同神经变性疾病，特别是阿尔茨海默病和血管性痴呆的个体的状况。

    Identification of Diagnostic Markers for Communicable Subacute Spongiform Encephalopathies
    8.
    发明申请
    Identification of Diagnostic Markers for Communicable Subacute Spongiform Encephalopathies 审中-公开
    识别传染性亚急性海绵状脑病的诊断标记

    公开(公告)号：US20070292850A1

    公开(公告)日：2007-12-20

    申请号：US10578672

    申请日：2004-11-10

    申请人： Annelies Resink ,  Magali Rouquette

    发明人： Annelies Resink ,  Magali Rouquette

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： C12Q1/6876

    摘要： The invention relates to biological markers of transmissible subacute spongiform encephalopathies and to uses thereof in diagnostic methods. The invention also relates to tools and/or kits that can be used for carrying out said methods (reagents, probes, primers, antibodies, chips, cells, etc.), to their preparation and to uses thereof. The invention can be used for detecting the presence of an infection in mammals including during the early phase.

    摘要翻译： 本发明涉及传染性亚急性海绵状脑病的生物标志物及其在诊断方法中的用途。 本发明还涉及可用于实施所述方法（试剂，探针，引物，抗体，芯片，细胞等）及其用途的工具和/或试剂盒。 本发明可用于检测哺乳动物感染的存在，包括在早期阶段。