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    System for indirectly ablating tissue using implanted electrode devices
    1.
    发明授权
    System for indirectly ablating tissue using implanted electrode devices 失效
    使用植入电极器件间接消融组织的系统

    公开(公告)号：US06979330B2

    公开(公告)日：2005-12-27

    申请号：US10387892

    申请日：2003-03-13

    申请人： Amy C. Kelly ,  Robert J. Garabedian ,  Steven K. Landreville

    发明人： Amy C. Kelly ,  Robert J. Garabedian ,  Steven K. Landreville

    IPC分类号： A61B18/14 ,  A61B19/00 ,  A61N1/06 ,  A61B18/18

    CPC分类号： A61B18/1477 ,  A61B90/39 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1495 ,  A61B2090/3987 ,  A61N1/06

    摘要： Systems and methods are provided for ablating tissue by implanting a plurality of electrode devices within the tissue to be treated and exposing the implanted electrode devices with RF energy conveyed from a separate electrode device. In this manner, a greater region of tissue is ablated than what would normally be ablated with the separate electrode device. In addition, the implanted electrode devices can create a roadmap that allows the progress of the treatment to be managed during follow-ups. The implanted electrode devices can be variously delivered to the tissue, for example, by detaching the electrode devices from one or more delivery devices. For example, a core wire with an electrolytically detachable junction can be used to separate the electrode device from the core wire. Pusher rods with mechanically detachable junctions are also contemplated.

    摘要翻译： 提供了系统和方法，用于通过将待治疗的组织内的多个电极装置植入而烧蚀组织，并且用从单独的电极装置输送的RF能量暴露所述植入的电极装置。 以这种方式，组织的较大区域比通常用单独的电极装置消融更多的区域被消融。 此外，植入的电极装置可以创建允许在随访期间对治疗进展进行管理的路线图。 植入的电极装置可以被不同地递送到组织，例如通过将电极装置从一个或多个递送装置分离。 例如，可以使用具有电解可分离结的芯线来将电极装置与芯线分离。 具有机械可拆卸接头的推杆也可以考虑。

    METHOD FOR INDIRECTLY ABLATING TISSUE USING IMPLANTED ELECTRODE DEVICES
    2.
    发明申请
    METHOD FOR INDIRECTLY ABLATING TISSUE USING IMPLANTED ELECTRODE DEVICES 失效
    用于使用植入式电极装置进行组织清除的方法

    公开(公告)号：US20100256633A1

    公开(公告)日：2010-10-07

    申请号：US12818091

    申请日：2010-06-17

    申请人： Amy C. Kelly ,  Robert J. Garabedian ,  Steven K. Landreville

    发明人： Amy C. Kelly ,  Robert J. Garabedian ,  Steven K. Landreville

    IPC分类号： A61B18/14

    CPC分类号： A61B18/1477 ,  A61B90/39 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1495 ,  A61B2090/3987 ,  A61N1/06

    摘要： Methods are provided for ablating tissue by implanting a plurality of electrode devices within the tissue to be treated and exposing the implanted electrode devices with RF energy conveyed from a separate electrode device. In this manner, a greater region of tissue is ablated than what would normally be ablated with the separate electrode device. In addition, the implanted electrode devices can create a roadmap that allows the progress of the treatment to be managed during follow-ups. The implanted electrode devices can be variously delivered to the tissue, for example, by detaching the electrode devices from one or more delivery devices. For example, a core wire with an electrolytically detachable junction can be used to separate the electrode device from the core wire. Pusher rods with mechanically detachable junctions are also contemplated.

    摘要翻译： 提供了用于通过在待治疗的组织内植入多个电极装置并且用从单独的电极装置输送的RF能量暴露所述植入的电极装置来烧蚀组织的方法。 以这种方式，组织的较大区域比通常用单独的电极装置消融更多的区域被消融。 此外，植入的电极装置可以创建允许在随访期间对治疗进展进行管理的路线图。 植入的电极装置可以被不同地递送到组织，例如通过将电极装置从一个或多个递送装置分离。 例如，可以使用具有电解可分离结的芯线来将电极装置与芯线分离。 具有机械可拆卸接头的推杆也可以考虑。

    Method for indirectly ablating tissue using implanted electrode device
    3.
    发明授权
    Method for indirectly ablating tissue using implanted electrode device 有权
    使用植入电极装置间接消融组织的方法

    公开(公告)号：US07749219B2

    公开(公告)日：2010-07-06

    申请号：US11258417

    申请日：2005-10-24

    申请人： Amy C. Kelly ,  Robert J. Garabedian ,  Steven K. Landreville

    发明人： Amy C. Kelly ,  Robert J. Garabedian ,  Steven K. Landreville

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1477 ,  A61B90/39 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1495 ,  A61B2090/3987 ,  A61N1/06

    摘要： Methods are provided for ablating tissue by implanting a plurality of electrode devices within the tissue to be treated and exposing the implanted electrode devices with RF energy conveyed from a separate electrode device. In this manner, a greater region of tissue is ablated than what would normally be ablated with the separate electrode device. In addition, the implanted electrode devices can create a roadmap that allows the progress of the treatment to be managed during follow-ups. The implanted electrode devices can be variously delivered to the tissue, for example, by detaching the electrode devices from one or more delivery devices. For example, a core wire with an electrolytically detachable junction can be used to separate the electrode device from the core wire. Pusher rods with mechanically detachable junctions are also contemplated.

    摘要翻译： 提供了用于通过在待治疗的组织内植入多个电极装置并且用从单独的电极装置输送的RF能量暴露所述植入的电极装置来烧蚀组织的方法。 以这种方式，组织的较大区域比通常用单独的电极装置消融更多的区域被消融。 此外，植入的电极装置可以创建允许在随访期间对治疗进展进行管理的路线图。 植入的电极装置可以被不同地递送到组织，例如通过将电极装置从一个或多个递送装置分离。 例如，可以使用具有电解可分离结的芯线来将电极装置与芯线分离。 具有机械可拆卸接头的推杆也可以考虑。

    TISSUE TREATMENT SYSTEM AND METHOD FOR TISSUE PERFUSION USING FEEDBACK CONTROL
    8.
    发明申请
    TISSUE TREATMENT SYSTEM AND METHOD FOR TISSUE PERFUSION USING FEEDBACK CONTROL 有权

    公开(公告)号：US20080221562A1

    公开(公告)日：2008-09-11

    申请号：US12037882

    申请日：2008-02-26

    申请人： Robert J. Garabedian ,  Amy C. Kelly ,  Steve K. Landreville

    发明人： Robert J. Garabedian ,  Amy C. Kelly ,  Steve K. Landreville

    IPC分类号： A61B18/14 ,  A61B18/12

    CPC分类号： A61B18/0206 ,  A61B18/12 ,  A61B18/1477 ,  A61B18/148 ,  A61B2018/00005 ,  A61B2018/00035 ,  A61B2018/00071 ,  A61B2018/00577 ,  A61B2018/00595 ,  A61B2018/00702 ,  A61B2018/00875 ,  A61B2018/00916 ,  A61B2018/00934 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1472 ,  A61B2018/1475 ,  A61B2218/002

    摘要： A system, ablation probe, and method is provided for treating tissue, e.g., tissue having tumors. The treatment system is configured to automatically deliver infusaid to tissue when needed and comprises an ablation probe having an ablative element and at least one perfusion exit port. The system further comprises an ablation source operably coupled to the ablative element, and a pump assembly operably coupled to the perfusion exit port(s). The pump assembly is configured for pumping infusaid out through the perfusion exit port(s), preferably during the ablation process. The system further comprises a feedback device configured for controlling the amount of infusaid displaced by the pump assembly based on a sensed tissue parameter, e.g., tissue temperature or tissue impedance. For example, the feedback device can comprise a sensor configured for sensing the tissue parameter, and a perfusion controller configured for controlling the pump assembly based on the sensed tissue parameter. As another example, the feedback device can comprise a perfusion valve associated with the distal end of the shaft. In this case, the perfusion valve forms the perfusion exit port, wherein the perfusion valve changes the size of the perfusion exit port based on tissue temperature.An ablation probe is provided for treating tissue, e.g., tissue having a tumor. The ablation comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and a perfusion control valve associated with the distal end of the shaft. The perfusion control valve has a port, the size of which changes with temperature. In one embodiment, the perfusion control valve comprises a reed valve having at least one reed, e.g., a pair of opposing reeds, or even four reeds. The reeds are configured change shape in order to control the size of the port. For example, each reed can comprise a bimetallic flange or a nitinol flange that bends in the presence of a temperature change.Ablation probes and systems are provided for treating tissue, e.g., tissue having a tumor. The ablation comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and at least one perfusion exit port in fluid communication with the perfusion lumen. The perfusion lumen can be used to deliver an infusaid to the perfusion exit port(s) for perfusion of the surrounding tissue. The ablation probe further comprises a wicking material, e.g., cotton or fabric, disposed in the perfusion lumen. In this manner, the infusaid that travels through the perfusion lumen can be controlled without regard to the size of the perfusion exit port(s).An ablation probe is provided for treating tissue, e.g., tissue having a tumor. The ablation probe comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and at least one perfusion exit port in fluid communication with the perfusion lumen. The ablation probe further comprises a pump assembly carried by the proximal end of the shaft. The pump assembly is configured for pumping infusaid through the perfusion lumen and out the perfusion exit port(s). In one embodiment, the pump assembly comprises a reservoir for storing the infusaid, and a perfusion inlet port configured for transferring infusaid from an external source into the reservoir. The pump assembly can be variously configured. For example, the pump assembly may comprise a diaphragm adjacent the reservoir. In this case, the diaphragm has pumping stroke that displaces the infusaid from the reservoir into the perfusion lumen. As another example, the pump assembly comprises a diaphragm adjacent the reservoir, wherein the diaphragm is configured for expanding to pressurize the reservoir in response to the conveyance of infusaid into the reservoir. As still another example, the pump assembly comprises a plunger disposed in the reservoir and a spring configured to urge the plunger within the reservoir in one direction to pressurize the reservoir.