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公开(公告)号:US09327036B2
公开(公告)日:2016-05-03
申请号:US13263129
申请日:2010-04-08
申请人: Shih-Chia Hsiao , Matthew B. Francis , Carolyn Bertozzi , Richard Mathies , Ravi Chandra , Erik Douglas , Amy Twite , Nicholas Toriello , Hiroaki Onoe
发明人: Shih-Chia Hsiao , Matthew B. Francis , Carolyn Bertozzi , Richard Mathies , Ravi Chandra , Erik Douglas , Amy Twite , Nicholas Toriello , Hiroaki Onoe
IPC分类号: C12N5/07 , C12N5/0789 , C07H21/00 , A61K47/48 , C12N5/00
CPC分类号: C12N5/0006 , A61K47/6901
摘要: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
摘要翻译: 本发明通过将DNA与细胞表面上的天然官能团连接来提供DNA和细胞的结合物。 细胞可以没有细胞壁或可以具有细胞壁。 修饰的细胞可以连接到底物表面并用于测定或生物反应器中。
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公开(公告)号:US20120142088A1
公开(公告)日:2012-06-07
申请号:US13263129
申请日:2010-04-08
申请人: Shih-Chia Hsiao , Matthew B. Francis , Carolyn Bertozzi , Richard Mathies , Ravi Chandra , Erik Douglas , Amy Twite , Nicholas Toriello , Hiroaki Onoe
发明人: Shih-Chia Hsiao , Matthew B. Francis , Carolyn Bertozzi , Richard Mathies , Ravi Chandra , Erik Douglas , Amy Twite , Nicholas Toriello , Hiroaki Onoe
IPC分类号: C12N5/07 , C07H21/00 , C12N5/0789 , C12N5/04
CPC分类号: C12N5/0006 , A61K47/6901
摘要: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.
摘要翻译: 本发明通过将DNA与细胞表面上的天然官能团连接来提供DNA和细胞的缀合物。 细胞可以没有细胞壁或可以具有细胞壁。 修饰的细胞可以连接到底物表面并用于测定或生物反应器中。
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