公开(公告)号：US06866759B2

公开(公告)日：2005-03-15

申请号：US09738462

申请日：2000-12-13

申请人： Robin R. Miles ,  Amy Wei-Yun Wang ,  Raymond P. Mariella, Jr.

发明人： Robin R. Miles ,  Amy Wei-Yun Wang ,  Raymond P. Mariella, Jr.

IPC分类号： G01N27/447 ,  G01N27/453

CPC分类号： G01N27/44773

摘要： A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative charge and by applying a voltage between adjacent electrodes the DNA is caused to move. By using a series of electrodes, when one electrode voltage or charge is made negative with respect to adjacent electrodes, the DNA is repelled away from this electrode and attached to a positive charged electrode of the series. By sequentially making the next electrode of the series negative, the DNA can be moved to and concentrated over the remaining positive electrodes.

摘要翻译： 用一系列薄膜电极图案化的流体通道使得可以将DNA移动并浓缩在通过流体通道的流体中。 DNA具有固有的负电荷，并且通过在相邻电极之间施加电压使DNA发生移动。 通过使用一系列电极，当相对于相邻电极使一个电极电压或电荷为负极时，DNA将从该电极排出并附着到该串联的正带电电极。 通过顺序地使串联的下一个电极为阴性，DNA可以移动到其余正极上并集中在剩余的正电极上。