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公开(公告)号：US06866759B2
公开(公告)日：2005-03-15
申请号：US09738462
申请日：2000-12-13
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44773
摘要： A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative charge and by applying a voltage between adjacent electrodes the DNA is caused to move. By using a series of electrodes, when one electrode voltage or charge is made negative with respect to adjacent electrodes, the DNA is repelled away from this electrode and attached to a positive charged electrode of the series. By sequentially making the next electrode of the series negative, the DNA can be moved to and concentrated over the remaining positive electrodes.
摘要翻译： 用一系列薄膜电极图案化的流体通道使得可以将DNA移动并浓缩在通过流体通道的流体中。 DNA具有固有的负电荷，并且通过在相邻电极之间施加电压使DNA发生移动。 通过使用一系列电极，当相对于相邻电极使一个电极电压或电荷为负极时，DNA将从该电极排出并附着到该串联的正带电电极。 通过顺序地使串联的下一个电极为阴性，DNA可以移动到其余正极上并集中在剩余的正电极上。
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2.发明授权Systems and methods for separating particles and/or substances from a sample fluid 有权用于从样品流体中分离颗粒和/或物质的系统和方法公开(公告)号：US09480935B2
公开(公告)日：2016-11-01
申请号：US12024762
申请日：2008-02-01
申请人： Raymond P. Mariella, Jr. , George M. Dougherty , John M. Dzenitis , Robin R. Miles , David S. Clague
发明人： Raymond P. Mariella, Jr. , George M. Dougherty , John M. Dzenitis , Robin R. Miles , David S. Clague
CPC分类号： B01D17/06 , G01N1/4077 , G01N2001/4072 , G01N2015/0288
摘要： Systems and methods for separating particles and/or toxins from a sample fluid. A method according to one embodiment comprises simultaneously passing a sample fluid and a buffer fluid through a chamber such that a fluidic interface is formed between the sample fluid and the buffer fluid as the fluids pass through the chamber, the sample fluid having particles of interest therein; applying a force to the fluids for urging the particles of interest to pass through the interface into the buffer fluid; and substantially separating the buffer fluid from the sample fluid.
摘要翻译： 用于从样品流体中分离颗粒和/或毒素的系统和方法。 根据一个实施方案的方法包括同时使样品流体和缓冲流体通过室，使得当流体通过室时在样品流体和缓冲流体之间形成流体界面，样品流体具有目标颗粒 ; 向流体施加力以促使感兴趣的颗粒通过界面进入缓冲流体; 并且从样品流体基本上分离缓冲流体。
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3.发明申请Systems and Methods for Separating Particles and/or Substances from a Sample Fluid 有权从样品流体中分离颗粒和/或物质的系统和方法公开(公告)号：US20090194420A1
公开(公告)日：2009-08-06
申请号：US12024762
申请日：2008-02-01
申请人： Raymond P. Mariella, JR. , George M. Dougherty , John M. Dzenitis , Robin R. Miles , David S. Clague
发明人： Raymond P. Mariella, JR. , George M. Dougherty , John M. Dzenitis , Robin R. Miles , David S. Clague
CPC分类号： B01D17/06 , G01N1/4077 , G01N2001/4072 , G01N2015/0288
摘要： Systems and methods for separating particles and/or toxins from a sample fluid. A method according to one embodiment comprises simultaneously passing a sample fluid and a buffer fluid through a chamber such that a fluidic interface is formed between the sample fluid and the buffer fluid as the fluids pass through the chambers the sample fluid having particles of interest therein; applying a force to the fluids for urging the particles of interest to pass through the interface into the buffer fluid; and substantially separating the buffer fluid from the sample fluid.
摘要翻译： 用于从样品流体中分离颗粒和/或毒素的系统和方法。 根据一个实施例的方法包括同时通过样品流体和缓冲流体通过室，使得当流体通过腔室时，在样品流体和缓冲流体之间形成流体界面，其中具有感兴趣的颗粒的样品流体; 向流体施加力以促使感兴趣的颗粒通过界面进入缓冲流体; 并且从样品流体基本上分离缓冲流体。
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公开(公告)号：US20120114088A1
公开(公告)日：2012-05-10
申请号：US13290282
申请日：2011-11-07
申请人： Peter A. Amendt , Robin R. Miles
发明人： Peter A. Amendt , Robin R. Miles
IPC分类号： G21B1/11
摘要： A hohlraum for an inertial confinement fusion power plant is disclosed. The hohlraum includes a generally cylindrical exterior surface, and an interior rugby ball-shaped surface. Windows over laser entrance holes at each end of the hohlraum enclose inert gas. Infrared reflectors on opposite sides of the central point reflect fusion chamber heat away from the capsule. P2 shields disposed on the infrared reflectors help assure an enhanced and more uniform x-ray bath for the fusion fuel capsule.
摘要翻译： 公开了一种用于惯性约束聚变发电厂的霍尔。 耳罩包括大致圆柱形的外表面和内部橄榄球的球形表面。 窗户两端的激光入口孔都包围惰性气体。 中心点相对侧的红外线反射器将聚合室的热量从胶囊反射出来。 设置在红外反射器上的P2屏蔽件有助于确保用于聚变燃料胶囊的增强的和更均匀的x射线浴。
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公开(公告)号：US06846639B2
公开(公告)日：2005-01-25
申请号：US09993870
申请日：2001-11-15
IPC分类号： G01N27/02 , G01N33/543 , G01N33/53
CPC分类号： G01N33/5438 , G01N27/3276 , Y10S435/817 , Y10S436/806 , Y10S436/823
摘要： The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode attach to the immobilized antibodies, which produces a change in impedance between two adjacent electrodes, which impedance change is measured and used to detect the presence of a pathogen. To amplify the signal, beads coated with antibodies are introduced and the beads would stick to the pathogen causing a greater change in impedance between the two adjacent electrodes.
摘要翻译： 使用阻抗测量来检测与抗体包被的珠粒相连的病原体的存在。 在流体装置中，将抗体固定在图案化交错电极的表面上。 流经电极的样品流体中的病原体附着于固定的抗体，其产生两个相邻电极之间的阻抗变化，该阻抗变化被测量并用于检测病原体的存在。 为了扩增信号，引入用抗体包被的珠粒，并且珠粒将粘附到病原体上，导致两个相邻电极之间的阻抗变化更大。
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公开(公告)号：US06811133B2
公开(公告)日：2004-11-02
申请号：US10218890
申请日：2002-08-14
申请人： Robin R. Miles
发明人： Robin R. Miles
IPC分类号： F16K3112
CPC分类号： F16K99/0001 , B01F11/0045 , B01F13/0059 , F15C5/00 , F16K99/0015 , F16K99/0048 , F16K2099/008 , F16K2099/0084
摘要： A hydraulically amplified microelectromechanical systems actuator. A piece of piezoelectric material or stacked piezo bimorph is bonded or deposited as a thin film. The piece is operatively connected to a primary membrane. A reservoir is operatively connected to the primary membrane. The reservoir contains a fluid. A membrane is operatively connected to the reservoir. In operation, energizing the piezoelectric material causing the piezoelectric material to bow. Bowing of the piezoelectric material causes movement of the primary membrane. Movement of the primary membrane results in a force in being transmitted to the liquid in the reservoir. The force in the liquid causes movement of the membrane. Movement of the membrane results in an operating actuator.
摘要翻译： 液压放大微机电系统执行机构。 一块压电材料或堆叠的压电双晶片作为薄膜结合或沉积。 该片可操作地连接到初级膜。 储存器可操作地连接到初级膜。 储存器包含流体。 膜可操作地连接到储存器。 在操作中，使导致压电材料弯曲的压电材料通电。 压电材料的弯曲导致初级膜的移动。 初级膜的运动导致在储存器中的液体中传递的力。 液体中的力导致膜的移动。 膜的运动导致操作致动器。
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公开(公告)号：US06787018B1
公开(公告)日：2004-09-07
申请号：US09733857
申请日：2000-12-08
IPC分类号： G01N24447
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2400/0418 , B01L2400/0424 , B03C5/026 , G01N15/0656 , G01N2001/4038
摘要： The use of dielectrophoresis to collect particles under the conditions of electrokinetically-driven flow. Dielectrophortic concentration of particles under electrokinetic flow is accomplished by interdigitated electrodes patterned on an inner surface of a microfluid channel, a DC voltage is applied across the ends to the channel, and an AC voltage is applied across the electrodes, and particles swept down the channel electrokinetically are trapped within the field established by the electrodes. The particles can be released when the voltage to the electrodes is released.
摘要翻译： 在电动驱动流动条件下使用介电电泳收集颗粒。 在电动流动下颗粒的电极间主动脉浓度通过图案化在微流体通道的内表面上的交错电极实现，直流电压跨越通道施加，并且在电极之间施加AC电压，并且将颗粒扫过通道 电动地被捕获在由电极建立的场内。 当电极的电压被释放时，可以释放颗粒。
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公开(公告)号：US09466397B2
公开(公告)日：2016-10-11
申请号：US13290282
申请日：2011-11-07
申请人： Peter A. Amendt , Robin R. Miles
发明人： Peter A. Amendt , Robin R. Miles
摘要： A hohlraum for an inertial confinement fusion power plant is disclosed. The hohlraum includes a generally cylindrical exterior surface, and an interior rugby ball-shaped surface. Windows over laser entrance holes at each end of the hohlraum enclose inert gas. Infrared reflectors on opposite sides of the central point reflect fusion chamber heat away from the capsule. P2 shields disposed on the infrared reflectors help assure an enhanced and more uniform x-ray bath for the fusion fuel capsule.
摘要翻译： 公开了一种用于惯性约束聚变发电厂的霍尔。 耳罩包括大致圆柱形的外表面和内部橄榄球的球形表面。 窗户两端的激光入口孔都包围惰性气体。 中心点相对侧的红外线反射器将聚合室的热量从胶囊反射出来。 设置在红外反射器上的P2屏蔽件有助于确保用于聚变燃料胶囊的增强型和更均匀的x射线浴。
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9.发明申请INTERTIAL CONFINEMENT FUSION POWER PLANT WHICH DECOUPLES LIFE-LIMITED COMPONENT FROM PLANT AVAILABILITY 审中-公开离岸配对融合发电厂，从厂房可用性解除生命有限成分公开(公告)号：US20140286471A1
公开(公告)日：2014-09-25
申请号：US13883982
申请日：2011-11-08
申请人： Edward I. Moses , Jeffery F. Latkowski , Thomas M. Anklam , Mary L. Spaeth , Anthony Michael Dunne , Richard H. Sawicki , Robert J. Deri , Robin R. Miles , Andrew J. Bayramian , Kenneth R. Manes , Peter A. Amendt , Alvin C. Erlandson
发明人： Edward I. Moses , Jeffery F. Latkowski , Thomas M. Anklam , Mary L. Spaeth , Anthony Michael Dunne , Richard H. Sawicki , Robert J. Deri , Robin R. Miles , Andrew J. Bayramian , Kenneth R. Manes , Peter A. Amendt , Alvin C. Erlandson
IPC分类号： G21B1/03
摘要： An architecture for a fusion power plant is disclosed. The plant includes a fusion chamber for producing neutrons from a fusion reaction, and a laser system in which lasers are arranged about a vacuum chamber to provide energy to the fusion chamber to initiate the fusion reaction. The beam paths between the lasers and the fusion chamber are configured to prevent neutrons from the fusion chamber from reaching the laser system at a level that would preclude human access to the laser system.
摘要翻译： 公开了一种用于融合发电厂的架构。 该设备包括用于从融合反应产生中子的熔化室，以及激光系统，其中激光器围绕真空室布置以向熔化室提供能量以启动聚变反应。 激光器和熔化室之间的光束路径被配置成防止来自熔融室的中子到达激光系统的水平，这将防止人类进入激光系统。
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公开(公告)号：US06733172B2
公开(公告)日：2004-05-11
申请号：US10096788
申请日：2002-03-11
IPC分类号： B01F1308
CPC分类号： B01F13/0071 , B01F13/0064 , B01F13/0077 , B01F13/0094 , B01F2005/0017
摘要： A magnetohydrodynamic fluidic system mixes a first substance and a second substance. A first substrate section includes a first flow channel and a first plurality of pairs of spaced electrodes operatively connected to the first flow channel. A second substrate section includes a second flow channel and a second plurality of pairs of spaced electrodes operatively connected to the second flow channel. A third substrate section includes a third flow channel and a third plurality of pairs of spaced electrodes operatively connected to the third flow channel. A magnetic section and a control section are operatively connected to the spaced electrodes. The first substrate section, the second substrate section, the third substrate section, the first plurality of pairs of spaced electrodes, the second plurality of pairs of spaced electrodes, the third plurality of pairs of spaced electrodes, the magnetic section, and the control section are operated to move the first substance through the first flow channel, the second substance through the second flow channel, and both the first substance and the second substance into the third flow channel where they are mixed.
摘要翻译： 磁流体动力学流体系统混合第一物质和第二物质。 第一衬底部分包括第一流动通道和可操作地连接到第一流动通道的第一组多对间隔开的电极。 第二衬底部分包括可操作地连接到第二流动通道的第二流动通道和第二组成对的间隔开的电极。 第三衬底部分包括可操作地连接到第三流动通道的第三流动通道和第三组多对间隔开的电极。 磁性部分和控制部分可操作地连接到间隔开的电极。 第一基板部分，第二基板部分，第三基板部分，第一多对间隔电极，第二多对间隔电极，第三多对隔开的电极，磁性部分和控制部分 操作以使第一物质通过第一流动通道，第二物质通过第二流动通道，以及第一物质和第二物质两者进入混合的第三流动通道。
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