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公开(公告)号:US20120264746A1
公开(公告)日:2012-10-18
申请号:US13537792
申请日:2012-06-29
IPC分类号: A61K31/5513 , A61P29/00 , A61P9/00 , C07D243/14 , A61P35/00
CPC分类号: C07D243/14
摘要: The described invention relates to compounds (I) which modulate cell migration, and find use in, for example, wound healing, cancer progression and angiogenesis. All definitions as in claim 1.
摘要翻译: 本发明涉及调节细胞迁移的化合物(I),可用于例如伤口愈合,癌症进展和血管发生。 权利要求1中的所有定义。
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公开(公告)号:US07811789B2
公开(公告)日:2010-10-12
申请号:US11929587
申请日:2007-10-30
IPC分类号: C12P21/02
CPC分类号: C07K16/24 , A61K38/00 , C07K14/52 , C07K2317/33 , C07K2317/34 , G01N2333/78
摘要: A recombinant polynucleotide encoding migrating stimulating factor (MSF) or variants or fragments or derivatives or fusions thereof or fusions of said variants or fragments or derivatives. Reagents are disclosed which can distinguish MSF and fibronectin, and which can distinguish polynucleotides which encode MSF or fibronectin. These reagents are believed to be useful in, for example, diagnosing cancer. MSF or variants or fragments or derivatives or fusions thereof, or fusions of said variants or fusions or derivatives, are useful in modulating cell migration and in wound healing.
摘要翻译: 编码迁移性刺激因子(MSF)或其变体或片段或衍生物或融合物或所述变体或片段或衍生物的融合物的重组多核苷酸。 公开了可以区分MSF和纤连蛋白的试剂,并且可以区分编码MSF或纤连蛋白的多核苷酸。 据信这些试剂可用于例如诊断癌症。 MSF或其变体或片段或衍生物或融合物,或所述变体或融合物或衍生物的融合物可用于调节细胞迁移和伤口愈合。
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公开(公告)号:US20090221561A1
公开(公告)日:2009-09-03
申请号:US12064535
申请日:2006-08-23
IPC分类号: A61K31/5513 , C07D243/14 , C12N5/06 , A61P17/02
CPC分类号: C07D243/14
摘要: The described invention relates to compounds which modulate cell migration, and find use in, for example, wound healing, cancer progression and angiogenesis.
摘要翻译: 所述发明涉及调节细胞迁移的化合物,并且可用于例如伤口愈合,癌症进展和血管发生。
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公开(公告)号:US08962615B2
公开(公告)日:2015-02-24
申请号:US13537792
申请日:2012-06-29
IPC分类号: A01N43/62 , A61K31/55 , C07D243/00 , C07D487/02 , C07D243/14
CPC分类号: C07D243/14
摘要: The described invention relates to compounds (I) which modulate cell migration, and find use in, for example, wound healing, cancer progression and angiogenesis. All definitions as in claim 1.
摘要翻译: 本发明涉及调节细胞迁移的化合物(I),可用于例如伤口愈合,癌症进展和血管发生。 权利要求1中的所有定义。
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公开(公告)号:US20080187962A1
公开(公告)日:2008-08-07
申请号:US11929587
申请日:2007-10-30
CPC分类号: C07K16/24 , A61K38/00 , C07K14/52 , C07K2317/33 , C07K2317/34 , G01N2333/78
摘要: A recombinant polynucleotide encoding migrating stimulating factor (MSF) or variants or fragments or derivatives or fusions thereof or fusions of said variants or fragments or derivatives. Reagents are disclosed which can distinghish MSF and fibronectin, and which can distinguish polynucleotides which encode MSF or fibronectin. These reagents are believed to be useful in, for example, diagnosing cancer. MSF or variants or fragments or derivatives or fusions thereof, or fusions of said variants or fusions or derivatives, are useful in modulating cell migration and in wound healing.
摘要翻译: 编码迁移性刺激因子(MSF)或其变体或片段或衍生物或融合物或所述变体或片段或衍生物的融合物的重组多核苷酸。 公开了可以分散MSF和纤连蛋白的试剂,并且可以区分编码MSF或纤连蛋白的多核苷酸。 据信这些试剂可用于例如诊断癌症。 MSF或其变体或片段或衍生物或融合物,或所述变体或融合物或衍生物的融合物可用于调节细胞迁移和伤口愈合。
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公开(公告)号:US07351810B1
公开(公告)日:2008-04-01
申请号:US09581651
申请日:1998-12-15
IPC分类号: C07H21/04
CPC分类号: C07K16/24 , A61K38/00 , C07K14/52 , C07K2317/33 , C07K2317/34 , G01N2333/78
摘要: A recombinant polynucleotide encoding migrating stimulating factor (MSF) or variants or fragments or derivatives or fusions thereof or fusions of said variants or fragments or derivatives. Reagents are disclosed which can distinguish MSF and fibronectin, and which can distinguish polynucleotides which encode MSF or fibronectin. These reagents are believed to be useful in, for example, diagnosing cancer. MSF or variants or fragments or derivatives or fusions thereof, or fusions of said variants or fusions or derivatives, are useful in modulating cell migration and in wound healing.
摘要翻译: 编码迁移性刺激因子(MSF)或其变体或片段或衍生物或融合物或所述变体或片段或衍生物的融合物的重组多核苷酸。 公开了可以区分MSF和纤连蛋白的试剂,并且可以区分编码MSF或纤连蛋白的多核苷酸。 据信这些试剂可用于例如诊断癌症。 MSF或其变体或片段或衍生物或融合物,或所述变体或融合物或衍生物的融合物可用于调节细胞迁移和伤口愈合。
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公开(公告)号:US08242108B2
公开(公告)日:2012-08-14
申请号:US12064535
申请日:2006-08-23
IPC分类号: A01N43/62 , A61K31/55 , C07D243/12
CPC分类号: C07D243/14
摘要: The described invention relates to compounds which modulate cell migration, and find use in, for example, wound healing, cancer progression and angiogenesis.
摘要翻译: 所述发明涉及调节细胞迁移的化合物,并且可用于例如伤口愈合,癌症进展和血管发生。
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