公开(公告)号：US07192952B2

公开(公告)日：2007-03-20

申请号：US11070056

申请日：2005-03-02

申请人： Anders Bendtz Kanstrup ,  Christian Klarner Sams ,  Jane Marie Lundbeck ,  Lise Brown Christiansen ,  Marit Kristiansen

发明人： Anders Bendtz Kanstrup ,  Christian Klarner Sams ,  Jane Marie Lundbeck ,  Lise Brown Christiansen ,  Marit Kristiansen

IPC分类号： C07D473/08 ,  C07D473/06 ,  A61K31/522 ,  A61K31/55 ,  A61P3/10

CPC分类号： C07D473/00 ,  C07D473/02

摘要： The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV of formula I, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity

摘要翻译： 本发明涉及式I的DPP-IV酶的治疗活性和选择性抑制剂，包含该化合物的药物组合物和这些化合物在制备用于治疗与被灭活的蛋白质相关的疾病的药物中的用途 通过DPP-IV，如2型糖尿病和肥胖

公开(公告)号：US07235538B2

公开(公告)日：2007-06-26

申请号：US10621302

申请日：2003-07-17

申请人： Anders Bendtz Kanstrup ,  Lise Brown Christiansen ,  Jane Marie Lundbeck ,  Christian K. Sams ,  Marit Kristiansen

发明人： Anders Bendtz Kanstrup ,  Lise Brown Christiansen ,  Jane Marie Lundbeck ,  Christian K. Sams ,  Marit Kristiansen

IPC分类号： A61K31/522 ,  A61K3/10 ,  A61K3/04 ,  C07D473/08 ,  C07D473/06

CPC分类号： C07D473/04 ,  C07D473/08

摘要： The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, which are of formula I wherein each n is one or two independently and R1, R2, R3, R6, R7, R9, and R10 are defined herein. The present invention also relates to pharmaceutical compositions comprising the compounds of formula I and the use of the compounds for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type-2 diabetes and obesity.

摘要翻译： 本发明涉及酶DPP-IV的治疗活性和选择性抑制剂，其具有式I，其中每个n独立地为一个或两个，R 1，R 2， R 3，R 6，R 7，R 9，R 9和R 10， >在本文中定义。 本发明还涉及包含式I化合物的药物组合物和该化合物用于治疗与通过DPP-IV失活的蛋白质例如2型糖尿病和肥胖相关的疾病的用途。

公开(公告)号：US06869947B2

公开(公告)日：2005-03-22

申请号：US10186498

申请日：2002-06-28

申请人： Anders Bendtz Kanstrup ,  Christian Klarner Sams ,  Jane Marie Lundbeck ,  Lise Brown Christiansen ,  Marit Kristiansen

发明人： Anders Bendtz Kanstrup ,  Christian Klarner Sams ,  Jane Marie Lundbeck ,  Lise Brown Christiansen ,  Marit Kristiansen

IPC分类号： A61P3/10 ,  C07D473/00 ,  C07D473/02 ,  C07D473/08 ,  A61K31/522 ,  A61K31/55 ,  C07D473/06

CPC分类号： C07D473/00 ,  C07D473/02

摘要： The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV of formula I, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity

摘要翻译： 本发明涉及式I的DPP-IV酶的治疗活性和选择性抑制剂，包含该化合物的药物组合物和这些化合物在制备用于治疗与被灭活的蛋白质相关的疾病的药物中的用途 通过DPP-IV，如2型糖尿病和肥胖