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公开(公告)号：US20130040823A1
公开(公告)日：2013-02-14
申请号：US13455223
申请日：2012-04-25
申请人： Per-Ola FRESKGARD , Thomas FRANCH , Alex Haahr GOULIAEV , Mikkel Dybro LUNDORF , Jakob FELDING , Eva Kampmann OLSEN , Anette HOLTMANN , Soeren Nyboe JAKOBSEN , Christian Klarner SAMS , Sanne Schroeder GLAD , Kim Birkebaek JENSEN , Henrik PEDERSEN
发明人： Per-Ola FRESKGARD , Thomas FRANCH , Alex Haahr GOULIAEV , Mikkel Dybro LUNDORF , Jakob FELDING , Eva Kampmann OLSEN , Anette HOLTMANN , Soeren Nyboe JAKOBSEN , Christian Klarner SAMS , Sanne Schroeder GLAD , Kim Birkebaek JENSEN , Henrik PEDERSEN
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 反应物，并且提供标识起始位点处的反应物的各个标签是使用一种或多种酶。
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公开(公告)号：US20090264300A1
公开(公告)日：2009-10-22
申请号：US12095778
申请日：2006-12-01
申请人： Thomas Franch , Mikkel Dybro Lundorf , Soren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sorensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Slok , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebaek Jensen , Lene Pedersen , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Sore Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
发明人： Thomas Franch , Mikkel Dybro Lundorf , Soren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sorensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Slok , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebaek Jensen , Lene Pedersen , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Sore Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
CPC分类号： C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
摘要翻译： 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。
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公开(公告)号：US08932992B2
公开(公告)日：2015-01-13
申请号：US12330709
申请日：2008-12-09
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号：US06869947B2
公开(公告)日：2005-03-22
申请号：US10186498
申请日：2002-06-28
申请人： Anders Bendtz Kanstrup , Christian Klarner Sams , Jane Marie Lundbeck , Lise Brown Christiansen , Marit Kristiansen
发明人： Anders Bendtz Kanstrup , Christian Klarner Sams , Jane Marie Lundbeck , Lise Brown Christiansen , Marit Kristiansen
IPC分类号： A61P3/10 , C07D473/00 , C07D473/02 , C07D473/08 , A61K31/522 , A61K31/55 , C07D473/06
CPC分类号： C07D473/00 , C07D473/02
摘要： The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV of formula I, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity
摘要翻译： 本发明涉及式I的DPP-IV酶的治疗活性和选择性抑制剂，包含该化合物的药物组合物和这些化合物在制备用于治疗与被灭活的蛋白质相关的疾病的药物中的用途 通过DPP-IV，如2型糖尿病和肥胖
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公开(公告)号：US09109248B2
公开(公告)日：2015-08-18
申请号：US13455223
申请日：2012-04-25
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 反应物，并且提供标识起始位点处的反应物的各个标签是使用一种或多种酶。
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公开(公告)号：US07727713B2
公开(公告)日：2010-06-01
申请号：US10175539
申请日：2002-06-20
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号：US07192952B2
公开(公告)日：2007-03-20
申请号：US11070056
申请日：2005-03-02
申请人： Anders Bendtz Kanstrup , Christian Klarner Sams , Jane Marie Lundbeck , Lise Brown Christiansen , Marit Kristiansen
发明人： Anders Bendtz Kanstrup , Christian Klarner Sams , Jane Marie Lundbeck , Lise Brown Christiansen , Marit Kristiansen
IPC分类号： C07D473/08 , C07D473/06 , A61K31/522 , A61K31/55 , A61P3/10
CPC分类号： C07D473/00 , C07D473/02
摘要： The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV of formula I, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity
摘要翻译： 本发明涉及式I的DPP-IV酶的治疗活性和选择性抑制剂，包含该化合物的药物组合物和这些化合物在制备用于治疗与被灭活的蛋白质相关的疾病的药物中的用途 通过DPP-IV，如2型糖尿病和肥胖
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公开(公告)号：US09574189B2
公开(公告)日：2017-02-21
申请号：US12095778
申请日：2006-12-01
申请人： Thomas Franch , Mikkel Dybro Lundorf , Søren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sørensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Sløk , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebæ Jensen , Lene Pedersen , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Søren Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgård , Alex Haahr Gouliaev , Henrik Pedersen
发明人： Thomas Franch , Mikkel Dybro Lundorf , Søren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sørensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Sløk , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebæ Jensen , Lene Pedersen , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Søren Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgård , Alex Haahr Gouliaev , Henrik Pedersen
CPC分类号： C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
摘要翻译： 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。
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公开(公告)号：US08206901B2
公开(公告)日：2012-06-26
申请号：US10525817
申请日：2003-10-30
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。
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公开(公告)号：US20100016177A1
公开(公告)日：2010-01-21
申请号：US12330709
申请日：2008-12-09
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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