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    Methods and Compositions for Improving Immune Response by a Nutraceutical Antioxidant
    1.
    发明申请
    Methods and Compositions for Improving Immune Response by a Nutraceutical Antioxidant 审中-公开
    用于改善营养抗氧化剂的免疫反应的方法和组合物

    公开(公告)号：US20130344106A1

    公开(公告)日：2013-12-26

    申请号：US13907799

    申请日：2013-05-31

    申请人： ANDRE E. NEL ,  HYON-JEEN KIM

    发明人： ANDRE E. NEL ,  HYON-JEEN KIM

    IPC分类号： A61K39/39

    CPC分类号： A61K39/39 ,  A61K36/31 ,  Y02A50/463 ,  Y02A50/465

    摘要： The present invention provides a new means of restoring the immune system in aging and immunocompromised individuals using an antioxidant nutraceutical. The nutraceutical stimulates the aging immune system through the Nrf2 master gene regulatory pathway. The invention is based in part on the discovery that the Nrf2 has antioxidant and immune restorative activity. The nutraceutical improves function of both the innate and adaptive immune systems.

    摘要翻译： 本发明提供使用抗氧化营养药物恢复老化和免疫受损个体的免疫系统的新方法。 营养药物通过Nrf2主基因调控途径刺激老化免疫系统。 本发明部分基于Nrf2具有抗氧化和免疫恢复活性的发现。 营养药物改善了先天和适应性免疫系统的功能。

    Accessing the toxic potential of nanomaterials
    2.
    发明授权
    Accessing the toxic potential of nanomaterials 有权
    获得纳米材料的毒性潜力

    公开(公告)号：US08512943B2

    公开(公告)日：2013-08-20

    申请号：US12095902

    申请日：2006-12-06

    申请人： Andre E. Nel

    发明人： Andre E. Nel

    IPC分类号： C12Q1/00 ,  C12Q1/68

    CPC分类号： G01N33/5014 ,  B82Y5/00 ,  B82Y30/00

    摘要： A method based is provided for determining the toxicity of engineered nanomaterials (NM). The method comprises in vitro assays for oxidative stress associated with exposure to engineered NM, which comprise assays for: reactive oxygen species production; phase II and glutathione antioxidant molecule expression; activation of MAP and NF-kappa B kinase signaling cascades; production of cytokines, chemokines and adhesion molecules; mitochondrial perturbation and apoptosis; and cellular uptake and subcellular localization of the NM. The method further comprises in vivo assays for oxidative stress in subjects exposed to NM.

    摘要翻译： 提供了一种基于确定工程纳米材料（NM）的毒性的方法。 该方法包括与暴露于工程化NM相关的氧化应激的体外测定，其包括用于：活性氧产生的测定; II期和谷胱甘肽抗氧化分子表达; MAP和NF-κB激酶信号级联的激活; 细胞因子，趋化因子和粘附分子的产生; 线粒体扰动和凋亡; 和NM的细胞摄取和亚细胞定位。 该方法还包括暴露于NM的受试者的氧化应激的体内测定。

    Accessing the Toxic Potential of Nanomaterials
    3.
    发明申请
    Accessing the Toxic Potential of Nanomaterials 有权
    获取纳米材料的毒性潜力

    公开(公告)号：US20080295187A1

    公开(公告)日：2008-11-27

    申请号：US12095902

    申请日：2006-12-06

    申请人： Andre E. Nel

    发明人： Andre E. Nel

    IPC分类号： A01K67/027 ,  C12Q1/02 ,  C12Q1/48 ,  C12Q1/28 ,  C12Q1/68

    CPC分类号： G01N33/5014 ,  B82Y5/00 ,  B82Y30/00

    摘要： A method based is provided for determining the toxicity of engineered nanomaterials (NM). The method comprises in vitro assays for oxidative stress associated with exposure to engineered NM, which comprise assays for: reactive oxygen species production; phase II and glutathione antioxidant molecule expression; activation of MAP and NF-kappa B kinase signaling cascades; production of cytokines, chemokines and adhesion molecules; mitochondrial perturbation and apoptosis; and cellular uptake and subcellular localization of the NM. The method further comprises in vivo assays for oxidative stress in subjects exposed to NM.

    摘要翻译： 提供了一种基于确定工程纳米材料（NM）的毒性的方法。 该方法包括与暴露于工程化NM相关的氧化应激的体外测定，其包括用于：活性氧产生的测定; II期和谷胱甘肽抗氧化分子表达; MAP和NF-κB激酶信号级联的激活; 细胞因子，趋化因子和粘附分子的产生; 线粒体扰动和凋亡; 和NM的细胞摄取和亚细胞定位。 该方法还包括暴露于NM的受试者的氧化应激的体内测定。