公开(公告)号：US20110301665A1

公开(公告)日：2011-12-08

申请号：US13128821

申请日：2009-11-12

申请人： Andre Mercanzini ,  Philippe Renaud

发明人： Andre Mercanzini ,  Philippe Renaud

IPC分类号： A61N1/05

CPC分类号： A61N1/0534 ,  A61B5/04001 ,  A61B5/6868 ,  A61B17/34 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/37205 ,  Y10T29/49117

摘要： Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an elongated probe shaft. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as deep within a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation.

摘要翻译： 本文描述的是微电极阵列器件及其制造和使用方法，以提供对神经靶标的高度局部化和有效的电刺激。 该装置包括沿细长探针轴布置的多个微电极元件。 微电极元件的尺寸和形状被设计成针对可能位于动物神经系统中的单个神经元，神经元组和神经组织，例如人类脑内深处。 有利地，神经学探针可用于促进神经系统靶的定位并保持植入用于长期监测和/或刺激。

公开(公告)号：US08788064B2

公开(公告)日：2014-07-22

申请号：US13128821

申请日：2009-11-12

申请人： Andre Mercanzini ,  Philippe Renaud

发明人： Andre Mercanzini ,  Philippe Renaud

IPC分类号： A61B5/04 ,  A61N1/05 ,  A61B5/00

CPC分类号： A61N1/0534 ,  A61B5/04001 ,  A61B5/6868 ,  A61B17/34 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/37205 ,  Y10T29/49117

摘要： Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an elongated probe shaft. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as deep within a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation.

摘要翻译： 本文描述的是微电极阵列器件及其制造和使用方法，以提供对神经靶标的高度局部化和有效的电刺激。 该装置包括沿细长探针轴布置的多个微电极元件。 微电极元件的尺寸和形状被设计成针对可能位于动物神经系统中的单个神经元，神经元组和神经组织，例如人类脑内深处。 有利地，神经学探针可用于促进神经系统靶的定位并保持植入用于长期监测和/或刺激。

公开(公告)号：US08788042B2

公开(公告)日：2014-07-22

申请号：US13056261

申请日：2009-07-29

申请人： Andre Mercanzini ,  Philippe Renaud

发明人： Andre Mercanzini ,  Philippe Renaud

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61B5/00 ,  A61B5/04 ,  A61B5/053

CPC分类号： A61N1/36125 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/053 ,  A61B5/4094 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36082 ,  A61N1/36171 ,  A61N1/36185

摘要： A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a microelectrode-tissue interface across a range of different frequencies. A preferred one of the measured electrical impedance values is identified as being closest to a pure resistance. The neurological target can then be stimulated at or near the frequency associated with the preferred impedance value (peak resistance frequency), thereby promoting desirable traits, such as optimum charge transfer, minimum signal distortion, increased stimulation efficiency, and prevention of microelectrode corrosion. The peak resistance frequency can be used to determine an preferred pulse shape. A target can be identified by microelectrode measurements of neuronal activity and/or impedance magnitude at peak resistance frequency.

摘要翻译： 鉴定优选频率，可用于使用位于靶附近或其附近的至少一个微电极来刺激哺乳动物体内的神经学靶。 为了建立有效和有效的刺激，提供阻抗分析器用于测量指示不同频率范围上的微电极 - 组织界面的电阻抗值。 所测量的电阻抗值中优选的一个被识别为最接近纯电阻。 然后可以在与优选阻抗值（峰值电阻频率）相关联的频率附近刺激神经学靶标，从而促进所需的性状，例如最佳电荷转移，最小信号失真，增加的刺激效率和防止微电极腐蚀。 峰值电阻频率可用于确定优选的脉冲形状。 可以通过微电极测量峰值电阻频率处的神经元活动和/或阻抗大小来鉴定靶标。

公开(公告)号：US20110295350A1

公开(公告)日：2011-12-01

申请号：US13056261

申请日：2009-07-29

申请人： Andre Mercanzini ,  Philippe Renaud

发明人： Andre Mercanzini ,  Philippe Renaud

IPC分类号： A61N1/05

CPC分类号： A61N1/36125 ,  A61B5/0031 ,  A61B5/04001 ,  A61B5/053 ,  A61B5/4094 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36082 ,  A61N1/36171 ,  A61N1/36185

摘要： A preferred frequency is identified, being usable to stimulate a neurological target within a mammalian body using at least one microelectrode positioned at or near the target. To establish efficient and effective stimulation, an impedance analyzer is provided for measuring electrical impedance values indicative of a microelectrode-tissue interface across a range of different frequencies. A preferred one of the measured electrical impedance values is identified as being closest to a pure resistance. The neurological target can then be stimulated at or near the frequency associated with the preferred impedance value (peak resistance frequency), thereby promoting desirable traits, such as optimum charge transfer, minimum signal distortion, increased stimulation efficiency, and prevention of microelectrode corrosion. The peak resistance frequency can be used to determine an preferred pulse shape. A target can be identified by microelectrode measurements of neuronal activity and/or impedance magnitude at peak resistance frequency.

摘要翻译： 鉴定优选频率，可用于使用位于靶附近或其附近的至少一个微电极来刺激哺乳动物体内的神经学靶。 为了建立有效和有效的刺激，提供阻抗分析器用于测量指示不同频率范围上的微电极 - 组织界面的电阻抗值。 所测量的电阻抗值中优选的一个被识别为最接近纯电阻。 然后可以在与优选阻抗值（峰值电阻频率）相关联的频率附近刺激神经学靶标，从而促进期望的特征，例如最佳电荷转移，最小信号失真，增加的刺激效率和防止微电极腐蚀。 峰值电阻频率可用于确定优选的脉冲形状。 可以通过微电极测量峰值电阻频率处的神经元活动和/或阻抗大小来鉴定靶标。