公开(公告)号：US20080156985A1

公开(公告)日：2008-07-03

申请号：US12005593

申请日：2007-12-27

申请人： Andre Venter ,  Robert Graham Cooks

发明人： Andre Venter ,  Robert Graham Cooks

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/165 ,  H01J49/142

摘要： An improvement to Desorption Electrospray Ionization (DESI), the process of creating ions directly from sample surfaces for mass spectrometric (MS) analysis by impinging a liquid spray onto the surface. The improvement is brought about by enclosing the spray and sample surface and MS-inlet capillary in a pressure tight enclosure. The invention includes methods of sampling a larger or smaller area of surface by impacting and collecting droplets from such an area. The invention allows DESI to be performed without need for careful control of the geometry of the sprayer and MS-inlet capillary positions and angles relative to the sample surface.

摘要翻译： 解吸电喷雾离子化（DESI）的改进，是通过将液体喷雾冲击到表面上，直接从样品表面产生离子进行质谱（MS）分析的过程。 通过将喷雾和样品表面和MS进样口毛细管封闭在压力密封的外壳中来实现改进。 本发明包括通过冲击和收集来自这样的区域的液滴来采样更大或更小的表面面积的方法。 本发明允许执行DESI，而无需仔细控制喷雾器的几何形状和相对于样品表面的MS入口毛细管位置和角度。

公开(公告)号：US07847244B2

公开(公告)日：2010-12-07

申请号：US12005593

申请日：2007-12-27

申请人： Andre Venter ,  Robert Graham Cooks

发明人： Andre Venter ,  Robert Graham Cooks

IPC分类号： B01D59/44

CPC分类号： H01J49/165 ,  H01J49/142

摘要： An improvement to Desorption Electrospray Ionization (DESI), the process of creating ions directly from sample surfaces for mass spectrometric (MS) analysis by impinging a liquid spray onto the surface. The improvement is brought about by enclosing the spray and sample surface and MS-inlet capillary in a pressure tight enclosure. The invention includes methods of sampling a larger or smaller area of surface by impacting and collecting droplets from such an area. The invention allows DESI to be performed without need for careful control of the geometry of the sprayer and MS-inlet capillary positions and angles relative to the sample surface.

摘要翻译： 解吸电喷雾离子化（DESI）的改进，是通过将液体喷雾冲击到表面上，直接从样品表面产生离子进行质谱（MS）分析的过程。 通过将喷雾和样品表面和MS进样口毛细管封闭在压力密封的外壳中来实现改进。 本发明包括通过冲击和收集来自这样的区域的液滴来采样更大或更小的表面面积的方法。 本发明允许执行DESI，而无需仔细控制喷雾器的几何形状和相对于样品表面的MS入口毛细管位置和角度。

公开(公告)号：US20130205921A1

公开(公告)日：2013-08-15

申请号：US13703110

申请日：2011-06-10

申请人： Andre Venter ,  Afrand Kamali

发明人： Andre Venter ,  Afrand Kamali

IPC分类号： G01N1/02

CPC分类号： G01N1/02 ,  G01N2001/028

摘要： A device for collecting material from a solid surface, and optionally concentrating the collected material, for subsequent analysis includes a nebulizer that generates and discharges a fluid stream, and a collector positioned to intercept material caused by the fluid stream after it is deflected from the solid surface. The device is usable in a sample collection process having steps of spraying a fluid stream of gas containing nebulized solvent as the solid surface, positioning a collector to intercept material carried by the fluid. The process may be repeated to concentrate the material being sampled.

摘要翻译： 用于从固体表面收集材料并且可选地浓缩所收集的材料用于随后分析的装置包括产生和排出流体流的雾化器和定位成拦截流体流从固体偏转之后引起的材料的收集器 表面。 该装置可用于样品收集过程，其具有喷射含有雾化溶剂的气体的流体流作为固体表面的步骤，定位收集器以截留由流体携带的材料。 可以重复该过程以集中待采样的材料。

公开(公告)号：US20080179511A1

公开(公告)日：2008-07-31

申请号：US11751718

申请日：2007-05-22

申请人： Huanwen Chen ,  Hao Chen ,  Andre Venter ,  R. Graham Cooks

发明人： Huanwen Chen ,  Hao Chen ,  Andre Venter ,  R. Graham Cooks

IPC分类号： H01J49/10

CPC分类号： H01J49/145 ,  H01J49/0445

摘要： A device enables direct, continual analysis by mass spectrometry of one or more analytes in a complex liquid sample. A first sprayer nebulizes the liquid sample, forming sample droplets. A second sprayer provides multiple charged droplets of a liquid solvent or solution. The first sprayer forms a first angle (β) relative to the second sprayer such that the analytes are transferred to the charged droplets and are desolvated to generate free gas phase ions in an interface of a mass spectrometer (MS).

摘要翻译： 一种器件可以通过在复杂液体样品中的一种或多种分析物的质谱进行直接，连续的分析。 第一喷雾器使液体样品雾化，形成样品液滴。 第二喷雾器提供液体溶剂或溶液的多个带电液滴。 第一喷雾器相对于第二喷雾器形成第一角度（β），使得分析物被转移到带电的液滴中并被去溶剂化以在质谱仪（MS）的界面中产生游离气相离子。