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    ION SOURCE AND MASS SPECTROMETER INCLUDING THE SAME
    1.
    发明公开
    ION SOURCE AND MASS SPECTROMETER INCLUDING THE SAME 审中-公开

    公开(公告)号：US20230420238A1

    公开(公告)日：2023-12-28

    申请号：US18037111

    申请日：2021-12-06

    申请人： HITACHI HIGH-TECH CORPORATION

    发明人： Yasushi TERUI ,  Kantarou MARUOKA

    IPC分类号： H01J49/04 ,  G01N30/72

    CPC分类号： H01J49/0445 ,  G01N30/72 ,  G01N2030/027

    摘要： An ion source includes: an atomizer configured to continuously introduce a liquid sample and atomize the liquid sample; a heating and mixing chamber configured to vaporize the atomized liquid sample; and a charge supply unit configured to ionize the vaporized liquid sample. The charge supply unit has a positive pressure with respect to the heating and mixing chamber. The vaporized liquid sample and a gaseous seed ion supplied from the charge supply unit are mixed in the heating and mixing chamber. An auxiliary gas for adjusting a gas flow rate in the heating and mixing chamber can be introduced into the heating and mixing chamber. The heating and mixing chamber has a chamber outlet configured to introduce the ionized liquid sample into a mass spectrometer. The chamber outlet is connected to a first pore of the mass spectrometer.

    COMBINED DEVICE FOR LIQUID-PHASE MASS SPECTROMETRY SAMPLING AND ELECTROSPRAY
    3.
    发明公开
    COMBINED DEVICE FOR LIQUID-PHASE MASS SPECTROMETRY SAMPLING AND ELECTROSPRAY 审中-公开

    公开(公告)号：US20230204547A1

    公开(公告)日：2023-06-29

    申请号：US18179530

    申请日：2023-03-07

    申请人： GUANGDONG LIANJIE BIOTECHNOLOGY CO., LTD

    发明人： Janshon ZHU

    IPC分类号： G01N30/72 ,  G01N30/24 ,  H01J49/16 ,  H01J49/04

    CPC分类号： G01N30/7266 ,  G01N30/24 ,  H01J49/165 ,  H01J49/0445

    摘要： The present disclosure is applicable to the field of analytical instruments, and provides a multifunctional probe for sample pickup, delivery and electrospray ionization used for direct sample analysis with a liquid-phase mass spectrometer. The multifunctional probe comprises a needle body and a tip part, wherein said tip part is continuously contracted from the needle body in whole or in part, and said tip part is provided with a solution carrying structure. The present disclosure further provides a combined sample introduction and electrospray device for liquid-phase mass spectrometry comprising said multifunctional probe, further comprising a mechanical arm and an ion source with a sealed chamber and a needle port on the sealed chamber.

    METHODS FOR ANALYZING STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT
    5.
    发明申请
    METHODS FOR ANALYZING STABILITY OF AN ACTIVE PHARMACEUTICAL INGREDIENT 审中-公开

    公开(公告)号：US20190219555A1

    公开(公告)日：2019-07-18

    申请号：US16245703

    申请日：2019-01-11

    申请人： Purdue Research Foundation

    发明人： Robert Graham Cooks ,  Roy Helmy ,  Yangjie Li ,  Yong Liu

    IPC分类号： G01N33/15 ,  H01J49/00 ,  H01J49/04

    CPC分类号： G01N33/15 ,  H01J49/0027 ,  H01J49/0445

    摘要： The invention generally relates to methods for analyzing stability of an active pharmaceutical agent. In certain aspects, the methods involve obtaining an active pharmaceutical agent, and distributing the active pharmaceutical agent into one or more microdroplets. The one or more microdroplets including the active pharmaceutical agent are then subjected to one or more conditions that force degradation of the active pharmaceutical agent in each of the one or more microdroplets. The one or more microdroplets are then analyzed to determine a ratio of the active pharmaceutical agent to that of a degradation product of the active pharmaceutical agent, thereby analyzing stability of an active pharmaceutical agent.

    Charge conditioner technology
    6.
    发明申请
    Charge conditioner technology 审中-公开

    公开(公告)号：US20180308675A1

    公开(公告)日：2018-10-25

    申请号：US15932767

    申请日：2018-04-23

    申请人： Derek Oberreit

    发明人： Derek Oberreit

    IPC分类号： H01J49/04 ,  H01J49/14

    CPC分类号： H01J49/0445 ,  G01N15/0656 ,  G01N2015/0046 ,  G21K5/10 ,  H01J49/145 ,  H05F3/06

    摘要： An aerosol charge conditioner includes a source of ionizing radiation, an ionization region, and a conduit transporting an aerosol sample through the ionization region. The conduit is constructed and arranged to control irradiation of the aerosol sample. The conduit includes an inlet conduit communicatively connected to an outlet conduit. The inlet conduit has a first diameter and a distal end disposed in the ionization region. The outlet conduit has a second diameter which is greater than the first diameter of the inlet conduit and a proximal end disposed in the ionization region. A secondary gas supply is communicatively connected to the ionization region. A method for controlled ionization of aerosol particles using radiation as a source is also disclosed.

    ION SOURCE AND METHOD FOR GENERATING ELEMENTAL IONS FROM AEROSOL PARTICLES
    7.
    发明申请
    ION SOURCE AND METHOD FOR GENERATING ELEMENTAL IONS FROM AEROSOL PARTICLES 审中-公开

    公开(公告)号：US20180294149A1

    公开(公告)日：2018-10-11

    申请号：US15857897

    申请日：2017-12-29

    申请人： TOFWERK AG

    发明人： Urs ROHNER

    IPC分类号： H01J49/04 ,  H01J49/14

    CPC分类号： H01J49/0445 ,  H01J27/24 ,  H01J49/14 ,  H01J49/161

    摘要： The invention relates to an ion source (50) for generating elemental ions and/or ionised metal oxides from aerosol particles, comprising: a reduced pressure chamber (61) having an inside; an inlet (56) and a flow restricting device (60) for inserting the aerosol particles in a dispersion comprising the aerosol particles dispersed in a gas, in particular in air, into the inside of the reduced pressure chamber (61), the inlet (60) fluidly coupling an outside of the reduced pressure chamber (61) via the flow restricting device (60) with the inside of the reduced pressure chamber (60); a laser (62) for inducing in a plasma region (63) in the inside of the reduced pressure chamber (61) a plasma in the dispersion for atomising and ionising the aerosol particles to elemental ions and/or ionised metal oxides; wherein the reduced pressure chamber (61) is adapted for achieving and maintaining in the inside of the reduced pressure chamber (61) a pressure in a range from 0.01 mbar to 100 mbar. The invention further relates to a method for generating elemental ions and/or ionised metal oxides from aerosol particles, comprising the steps of inserting aerosol particles in a dispersion comprising the aerosol particles dispersed in a gas, in particular in air, through an inlet (56) via a flow restricting device (60) into an inside of a reduced pressure chamber (61), while maintaining in the inside of the reduced pressure chamber (61) a pressure in a range from 0.01 mbar to 100 mbar, preferably from 0.1 mbar to 100 mbar or from 1 mbar to 100 mbar, particular preferably from 0.1 mbar to 50 mbar or from 1 mbar to 50 mbar, most preferably from 0.1 mbar to 40 mbar or from 1 mbar to 40 mbar; and inducing with a laser (62) in a plasma region (63) in the inside of the reduced pressure chamber (61) a plasma in the dispersion for atomising and ionising the aerosol particles to elemental ions and/or ionised metal oxides, wherein the laser (62) is adapted for inducing in the plasma region (63) in the inside of the reduced pressure chamber (61) the plasma in the gas of the dispersion for atomising and ionising the aerosol particles to elemental ions.