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1.发明申请公开(公告)号：US20190157060A1
公开(公告)日：2019-05-23
申请号：US16198667
申请日：2018-11-21
发明人： Sammy Datwani , Donald W. Arnold , Lucien P. Ghislain , Chang Liu , Thomas Covey
CPC分类号： H01J49/0454 , B01L3/0268 , B01L2400/0439 , H01J49/0031 , H01J49/0404 , H01J49/165
摘要： A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection (“ADE”) in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.
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公开(公告)号：US20190108992A1
公开(公告)日：2019-04-11
申请号：US16211459
申请日：2018-12-06
IPC分类号： H01J49/04 , G01N27/447
CPC分类号： H01J49/0459 , G01N27/4473 , G01N27/44743 , G01N27/44791 , H01J49/165
摘要： Methods, systems and devices that provide fluid devices with at least one SPE bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a Mass Spectrometer. The fluid device can be configured to operate using independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer but optical or other electronic detectors may also be used with the fluidic devices.
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公开(公告)号：US20190101527A1
公开(公告)日：2019-04-04
申请号：US16132076
申请日：2018-09-14
申请人： Seer, Inc.
CPC分类号： G01N33/50 , A61B5/150755 , G01N27/26 , G16B20/00 , G16B40/00 , H01J49/00 , H01J49/0027 , H01J49/165 , Y02A90/22 , Y02A90/26 , Y10T436/117497
摘要： A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.
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公开(公告)号：US10157734B2
公开(公告)日：2018-12-18
申请号：US14720360
申请日：2015-05-22
申请人： Oxoid Limited
发明人： James L. Stephenson, Jr. , Oksana Gvozdyak , Roger Grist , Clay Campbell , Iain C. Mylchreest , Ian D. Jardine
CPC分类号： H01J49/0031 , C12Q1/04 , C12Q1/70 , G01N30/7233 , G01N33/6848 , G01N33/6851 , H01J49/0036 , H01J49/165
摘要： Methods and systems for identification of microorganisms either after isolation from a culture or directly from a sample. The methods and systems are configured to identify microorganisms based on the characterization of proteins of the microorganisms via high-resolution/mass accuracy single-stage (MS) or multi-stage (MSn) mass spectrometry. Included herein are also discussion of targeted detection and evaluation of virulence factors, antibiotic resistance markers, antibiotic susceptibility markers, typing, or other characteristics using a method applicable to substantially all microorganisms and high-resolution/mass accuracy single-stage (MS) or multi-stage (MSn) mass spectrometry.
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5.发明申请公开(公告)号：US20180301326A1
公开(公告)日：2018-10-18
申请号：US15881698
申请日：2018-01-26
申请人： Marshall BERN
发明人： Marshall BERN
CPC分类号： H01J49/0036 , H01J49/165
摘要： Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. The method involves using a measured spectrum of data from a sample taken with a mass spectrometer, deconvoluting the measured spectrum of data by applying parsimony weighting to minimize the number of charge states based on one or more of: the number of intense peaks in the mass spectrum; the number of harmonic relationships (e.g., masses in small integer ratios); and the number of off-by-one relationships (e.g., m/z bins with high probability for two adjacent charges). Thus, the underlying m/z spectrum may be inferred from the family of plausible deconvoluted spectra determined by applying parsimony and the inferred m/z spectrum may be used to identify and/or characterize the sample.
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公开(公告)号：US20180217157A1
公开(公告)日：2018-08-02
申请号：US15939030
申请日：2018-03-28
发明人： Nigel CLARKE , Zhaohui CHEN
CPC分类号： G01N33/6848 , G01N30/7266 , G01N33/487 , G01N33/74 , G01N2030/027 , G01N2333/62 , G01N2560/00 , H01J49/005 , H01J49/165 , H01J49/40
摘要： Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
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公开(公告)号：US09964546B1
公开(公告)日：2018-05-08
申请号：US15888681
申请日：2018-02-05
发明人： Nigel Clarke , Zhaohui Chen
CPC分类号： G01N33/6848 , G01N30/7266 , G01N33/487 , G01N33/74 , G01N2030/027 , G01N2333/62 , G01N2560/00 , H01J49/005 , H01J49/165 , H01J49/40
摘要： Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
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公开(公告)号：US09921195B2
公开(公告)日：2018-03-20
申请号：US15110028
申请日：2014-12-05
发明人： Mitsuhiro Umeda , Shinji Yoshioka , Masaki Yoshie , Yasushi Terui
CPC分类号： G01N30/7266 , H01J49/06 , H01J49/061 , H01J49/165 , H01J49/24
摘要： This invention improves the sensitivity of a liquid chromatography-mass spectrometry device by reducing the number of neutral particles that are not ionized during ionization and the number of low-molecular ions from a solvent used in the liquid chromatography. Said liquid chromatography-mass spectrometry device is provided with ion sources, a mass spectrometry unit, a detector, and three electrodes laid out so as to be parallel to each other. The first electrode and the second electrode have openings that allow ions to pass therethrough. The trajectories of said ions are deflected between the second electrode and the third electrode, thereby directing ions generated by the ion sources towards the mass spectrometry unit.
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公开(公告)号：US20180076015A1
公开(公告)日：2018-03-15
申请号：US15812913
申请日：2017-11-14
申请人： IONSENSE INC.
发明人： Brian D. Musselman
CPC分类号： H01J49/165 , G01N1/4022 , G01N2001/028 , G01N2030/009 , G01N2030/062 , H01J49/0031 , H01J49/045 , H01J49/16
摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.
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公开(公告)号：US09892901B2
公开(公告)日：2018-02-13
申请号：US15324092
申请日：2015-06-15
CPC分类号： H01J49/24 , G01N27/62 , H01J49/0404 , H01J49/0422 , H01J49/067 , H01J49/165 , H01J49/34
摘要： A mass spectrometry device that can perform highly robust, highly sensitive, and low-noise analysis and addresses the problems of preventing reductions in ion transfer efficiency and of suppressing the introduction of noise components from droplets, etc. An ion source generates ions, a vacuum chamber is evacuated by an evacuation means and for analyzing the mass of ions, and an ion introduction electrode introduces ions into the vacuum chamber. The ion introduction electrode has an ion-source-side front-stage pore, a vacuum-chamber-side rear-stage pore, and an intermediate pressure chamber between the front-stage pore and the rear-stage pore, the cross-sectional area of an ion inlet of the intermediate pressure chamber is larger than the cross-sectional area of the front-stage pore, the position of the central axis of the front-stage pore and the position of the central axis of the rear-stage pore are eccentric, and the cross-sectional area of an ion outlet of the intermediate pressure chamber is smaller than the cross-sectional area of the ion inlet.
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