公开(公告)号：US09157921B2

公开(公告)日：2015-10-13

申请号：US13475305

申请日：2012-05-18

申请人： Robert Graham Cooks ,  Livia Schiavinato Eberlin ,  Christina Ramires Ferreira ,  Allison Lisa Dill ,  Demian R. Ifa

发明人： Robert Graham Cooks ,  Livia Schiavinato Eberlin ,  Christina Ramires Ferreira ,  Allison Lisa Dill ,  Demian R. Ifa

IPC分类号： G01N33/92 ,  H01J49/00 ,  H01J49/14

CPC分类号： G01N33/92 ,  H01J49/0004 ,  H01J49/0036 ,  H01J49/142 ,  H01J49/165

摘要： The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis.

摘要翻译： 本发明一般涉及质谱分析。 在某些实施方案中，本发明的方法涉及使用质谱技术分析含脂质样品，其中该技术利用在分析期间不破坏天然组织形态的液相。

公开(公告)号：US09024254B2

公开(公告)日：2015-05-05

申请号：US13486824

申请日：2012-06-01

申请人： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato

发明人： Robert Graham Cooks ,  Zheng Ouyang ,  Chien-Hsun Chen ,  Ziqing Lin ,  Livia Schiavinato

IPC分类号： H01J49/00 ,  H01J49/04 ,  A61B10/00 ,  A61B5/15 ,  A61B5/145 ,  A61B5/157 ,  G01N1/02

CPC分类号： A61B5/1477 ,  A61B5/1405 ,  A61B5/145 ,  A61B5/150015 ,  A61B5/150992 ,  A61B5/157 ,  A61B10/0045 ,  A61M11/00 ,  A61M25/00 ,  A61M2202/0468 ,  G01N33/4833 ,  G01N2001/028 ,  H01J49/0022 ,  H01J49/0404 ,  H01J49/0445 ,  H01J49/167 ,  H01J49/34

摘要： The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

摘要翻译： 本发明一般涉及封闭的解吸电喷雾离子化探针，系统和方法。 在某些实施方案中，本发明提供DESI活性喷雾源，其中将源的远端部分包封在转移构件内，使得DESI活性喷雾在转移构件内产生。

公开(公告)号：US08932875B2

公开(公告)日：2015-01-13

申请号：US13977758

申请日：2011-12-29

申请人： Robert Graham Cooks ,  Guangtao Li ,  Xin Li ,  Zheng Ouyang

发明人： Robert Graham Cooks ,  Guangtao Li ,  Xin Li ,  Zheng Ouyang

IPC分类号： G01N33/28 ,  H01J49/26 ,  H01J49/42 ,  H01J49/04

CPC分类号： H01J49/0459 ,  G01N33/28 ,  H01J49/0031 ,  H01J49/0431 ,  H01J49/06 ,  H01J49/42 ,  Y10T436/214 ,  Y10T436/24 ,  Y10T436/25875

摘要： The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer.

摘要翻译： 本发明一般涉及用于样品分析的系统和方法。 在某些实施例中，本发明提供一种用于分析样品的系统，该样品包括包括连接到高压源的材料的探针，用于产生加热气体的装置和质量分析器。

公开(公告)号：US08766178B2

公开(公告)日：2014-07-01

申请号：US13633281

申请日：2012-10-02

申请人： Zheng Ouyang ,  Liang Gao ,  Robert Graham Cooks

发明人： Zheng Ouyang ,  Liang Gao ,  Robert Graham Cooks

IPC分类号： H01J49/10 ,  H01J49/00 ,  H01J49/04 ,  H01J49/24

CPC分类号： H01J49/24 ,  H01J49/00 ,  H01J49/0013 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0404 ,  H01J49/0422 ,  H01J49/0495 ,  H01J49/10 ,  H01J49/165 ,  H01J49/26

摘要： A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.

公开(公告)号：US20090261247A1

公开(公告)日：2009-10-22

申请号：US11814334

申请日：2006-02-07

申请人： Robert Graham Cooks ,  Zheng Ouyang ,  Yishu Song ,  Guangxiang Wu

发明人： Robert Graham Cooks ,  Zheng Ouyang ,  Yishu Song ,  Guangxiang Wu

IPC分类号： B01D59/44

CPC分类号： H01J49/422

摘要： A rectilinear ion trap includes a first pair of spaced planar RF electrodes, mounted in parallel and a second pair of spaced planar electrodes, mounted in parallel and orthogonal to the first pair of electrodes. The configuration of the pairs of electrodes define an axial direction and a radial direction. The trap further includes an RF source that applies an RF voltage to at least one of the pairs of RF electrodes to generate RF fields to trap ions in the axial and radial directions.

摘要翻译： 直线离子阱包括并联安装的第一对隔开的平面RF电极和与第一对电极正交安装的第二对隔开的平面电极。 电极对的配置限定了轴向和径向方向。 陷阱还包括RF源，其将RF电压施加到至少一对RF电极以产生RF场以在离子的轴向和径向方向捕获离子。

公开(公告)号：US20130181010A1

公开(公告)日：2013-07-18

申请号：US13784094

申请日：2013-03-04

申请人： Zheng Ouyang ,  He Wang ,  Nicholas E. Manicke ,  Robert Graham Cooks ,  Qian Yang ,  Jiangjiang Liu

发明人： Zheng Ouyang ,  He Wang ,  Nicholas E. Manicke ,  Robert Graham Cooks ,  Qian Yang ,  Jiangjiang Liu

IPC分类号： B65D37/00

CPC分类号： G01N33/492 ,  G01N1/10 ,  G01N1/28 ,  G01N1/286 ,  G01N33/48714 ,  G01N33/48785 ,  G01N33/491 ,  G01N2001/2893 ,  H01J49/0009 ,  H01J49/0027 ,  H01J49/16

摘要： The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.

摘要翻译： 本发明一般涉及一种包括内部标准的样品分配器及其使用方法。

公开(公告)号：US20130126723A1

公开(公告)日：2013-05-23

申请号：US13727840

申请日：2012-12-27

申请人： Zheng Ouyang ,  Robert Graham Cooks ,  Sandilya Venkata Garimella ,  Jason David Harper ,  Nicholas Alan Charipar

发明人： Zheng Ouyang ,  Robert Graham Cooks ,  Sandilya Venkata Garimella ,  Jason David Harper ,  Nicholas Alan Charipar

IPC分类号： H01J49/26 ,  H01J49/00 ,  H01J49/40

CPC分类号： H01J49/0404 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0422 ,  H01J49/0459 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/4215

摘要： The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

公开(公告)号：US08362418B2

公开(公告)日：2013-01-29

申请号：US12990688

申请日：2009-05-29

申请人： Wei Xu ,  William Chappell ,  Zheng Ouyang ,  Robert Graham Cooks

发明人： Wei Xu ,  William Chappell ,  Zheng Ouyang ,  Robert Graham Cooks

IPC分类号： B01D59/44

CPC分类号： H01J49/426 ,  H01J49/027

摘要： The invention herein generally relates to non-destructive, high order harmonic ion motion image current detection. In certain embodiments, ion motion corresponding to high order harmonic frequencies, instead of the secular frequencies, is detected using image current detection with a constant excitation applied to the waveform signal.

摘要翻译： 本发明一般涉及非破坏性高次谐波离子运动图像电流检测。 在某些实施例中，使用施加到波形信号的恒定激励的图像电流检测来检测对应于高次谐波频率而不是长期频率的离子运动。

公开(公告)号：US20110042560A1

公开(公告)日：2011-02-24

申请号：US12863801

申请日：2009-02-11

申请人： Zheng Ouyang ,  Jason Harper ,  Nicholas Charipar ,  Robert Graham Cooks

发明人： Zheng Ouyang ,  Jason Harper ,  Nicholas Charipar ,  Robert Graham Cooks

IPC分类号： H01J49/26

CPC分类号： H01J37/32009 ,  H01J27/022 ,  H01J37/00 ,  H01J37/32348 ,  H01J49/02 ,  H01J49/105 ,  H01J49/142 ,  H01J2237/0044 ,  H05H1/24 ,  H05H1/2406 ,  H05H1/30 ,  H05H2001/2412 ,  H05H2001/2443 ,  H05H2240/10 ,  H05H2240/20 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/173076 ,  Y10T436/203332 ,  Y10T436/24

摘要： The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.

摘要翻译： 本发明一般涉及用于解吸和电离样品中至少一种分析物的低温等离子体探针及其使用方法。 在一个实施方案中，本发明一般涉及一种低温等离子体探针，其包括：壳体，其具有放电气体入口端口，探针尖端，两个电极和介电屏障，其中两个电极由电介质屏障隔开， 来自电源的电压的施加产生低温等离子体，其中通过电场和/或放电气体流将低温等离子体推出排出区域。

公开(公告)号：US07847244B2

公开(公告)日：2010-12-07

申请号：US12005593

申请日：2007-12-27

申请人： Andre Venter ,  Robert Graham Cooks

发明人： Andre Venter ,  Robert Graham Cooks

IPC分类号： B01D59/44

CPC分类号： H01J49/165 ,  H01J49/142

摘要： An improvement to Desorption Electrospray Ionization (DESI), the process of creating ions directly from sample surfaces for mass spectrometric (MS) analysis by impinging a liquid spray onto the surface. The improvement is brought about by enclosing the spray and sample surface and MS-inlet capillary in a pressure tight enclosure. The invention includes methods of sampling a larger or smaller area of surface by impacting and collecting droplets from such an area. The invention allows DESI to be performed without need for careful control of the geometry of the sprayer and MS-inlet capillary positions and angles relative to the sample surface.

摘要翻译： 解吸电喷雾离子化（DESI）的改进，是通过将液体喷雾冲击到表面上，直接从样品表面产生离子进行质谱（MS）分析的过程。 通过将喷雾和样品表面和MS进样口毛细管封闭在压力密封的外壳中来实现改进。 本发明包括通过冲击和收集来自这样的区域的液滴来采样更大或更小的表面面积的方法。 本发明允许执行DESI，而无需仔细控制喷雾器的几何形状和相对于样品表面的MS入口毛细管位置和角度。