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公开(公告)号：US09243066B2
公开(公告)日：2016-01-26
申请号：US14126878
申请日：2012-07-17
Applicant: Stefan Steidl , John Allan Hamilton , Andrew David Cook
Inventor： Stefan Steidl , John Allan Hamilton , Andrew David Cook
IPC: A61K39/395 , C07K16/24 , C07K16/28 , A61K39/00
CPC classification number: C07K16/2866 , A61K2039/505 , C07K16/243 , C07K16/244 , C07K16/249 , C07K2317/76
Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.
Abstract translation: 本发明一般涉及治疗和/或预防骨关节炎（OA）和/或疼痛的方法。 根据本发明，c-Fms的拮抗剂对于治疗骨关节炎和/或疼痛是有效的。 M-CSF的拮抗剂包括但不限于对M-CSF，IL-34或c-Fms特异性的抗体。
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公开(公告)号：US09197109B2
公开(公告)日：2015-11-24
申请号：US13415723
申请日：2012-03-08
Applicant: John Christen Oleson , Andrew David Cook
Inventor： John Christen Oleson , Andrew David Cook
Abstract: An electric motor having a casing positioned between a head end cap and a tail end cap is provided. An output shaft passes through the head end cap and the tail end cap and a cooling fan is mounted for rotation relative to the output shaft. The electric motor includes a fluid distribution chamber adjacent the tail end cap, an inlet port for supply of fluid to the chamber, and a plurality of discharge apertures for distributing fluid from the chamber toward the cooling fan. The fluid distribution chamber facilitates the washing and cleaning of the electric motor.
Abstract translation: 提供一种具有位于头端盖和尾端盖之间的壳体的电动机。 输出轴通过头端盖和尾端盖，并且安装有用于相对于输出轴旋转的冷却风扇。 电动机包括与尾端盖相邻的流体分配室，用于向室供应流体的入口端口和用于将流体从室朝向冷却风扇分配的多个排出孔。 流体分配室便于电动机的清洗和清洗。
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公开(公告)号：US09243061B2
公开(公告)日：2016-01-26
申请号：US13140467
申请日：2009-12-21
Applicant: John Allan Hamilton , Andrew David Cook
Inventor： John Allan Hamilton , Andrew David Cook
IPC: C07K16/24 , A61K39/395 , A61K39/00
CPC classification number: C07K16/2866 , A61K39/395 , A61K2039/505 , C07K16/243 , C07K2317/24 , C07K2317/565 , C07K2317/76
Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
Abstract translation: 本发明一般涉及治疗和/或预防骨关节炎（OA）的方法。 根据本发明，GM-CSF拮抗剂可有效治疗骨关节炎。 GM-CSF的拮抗剂包括但不限于对GM-CSF或GM-CSF受体特异的抗体。 本发明还提供了可用于在某些疾病模型中测试拮抗剂的转基因动物，例如GM-CSF敲除小鼠。
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公开(公告)号：US20130234541A1
公开(公告)日：2013-09-12
申请号：US13415723
申请日：2012-03-08
Applicant: John Christen Oleson , Andrew David Cook
Inventor： John Christen Oleson , Andrew David Cook
IPC: H02K9/04
Abstract: An electric motor having a casing positioned between a head end cap and a tail end cap is provided. An output shaft passes through the head end cap and the tail end cap and a cooling fan is mounted for rotation relative to the output shaft. The electric motor includes a fluid distribution chamber adjacent the tail end cap, an inlet port for supply of fluid to the chamber, and a plurality of discharge apertures for distributing fluid from the chamber toward the cooling fan. The fluid distribution chamber facilitates the washing and cleaning of the electric motor.
Abstract translation: 提供一种具有位于头端盖和尾端盖之间的壳体的电动机。 输出轴通过头端盖和尾端盖，并且安装有用于相对于输出轴旋转的冷却风扇。 电动机包括与尾端盖相邻的流体分配室，用于向室供应流体的入口端口和用于将流体从室朝向冷却风扇分配的多个排出孔。 流体分配室便于电动机的清洗和清洗。
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公开(公告)号：US20120003234A1
公开(公告)日：2012-01-05
申请号：US13140467
申请日：2009-12-21
Applicant: John Allan Hamilton , Andrew David Cook
Inventor： John Allan Hamilton , Andrew David Cook
IPC: A61K39/395 , A61P19/02
CPC classification number: C07K16/2866 , A61K39/395 , A61K2039/505 , C07K16/243 , C07K2317/24 , C07K2317/565 , C07K2317/76
Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
Abstract translation: 本发明一般涉及治疗和/或预防骨关节炎（OA）的方法。 根据本发明，GM-CSF拮抗剂可有效治疗骨关节炎。 GM-CSF的拮抗剂包括但不限于对GM-CSF或GM-CSF受体特异的抗体。 本发明还提供了可用于在某些疾病模型中测试拮抗剂的转基因动物，例如GM-CSF敲除小鼠。
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Patent Agency Ranking
公开(公告)号：US08475796B2
公开(公告)日：2013-07-02
申请号：US13140839
申请日：2009-12-21
Applicant: John Allan Hamilton , Andrew David Cook
Inventor： John Allan Hamilton , Andrew David Cook
IPC: A61K39/395 , C07K16/24
CPC classification number: C07K16/243 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/56 , C07K2317/565 , C07K2317/76
Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
Abstract translation: 本发明一般涉及治疗和预防疼痛的方法。 根据本发明，提出GM-CSF的拮抗剂对于疼痛的治疗是有效的。 GM-CSF的拮抗剂包括但不限于对GM-CSF或GM-CSF受体特异的抗体。 本发明还提供了可用于在某些疾病模型中测试拮抗剂的转基因动物，例如GM-CSF敲除小鼠。
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公开(公告)号：US08227947B2
公开(公告)日：2012-07-24
申请号：US12538556
申请日：2009-08-10
Applicant: John Christen Oleson , Andrew David Cook
Inventor： John Christen Oleson , Andrew David Cook
IPC: H02H5/12
Abstract: An electric motor is provided that is configured for operation in hazardous or other hazardous environments. The electric motor includes a housing for a rotor and a stator. The housing includes a pair of end caps and a casing positioned therebetween. The end caps and the casing are held together using internal tie bars extending between and connected to the end caps.
Abstract translation: 提供了一种电动机，配置用于在危险或其他危险环境中运行。 电动机包括用于转子和定子的壳体。 壳体包括一对端盖和位于其间的壳体。 端盖和外壳使用在端盖之间延伸并连接到端盖的内部连接杆保持在一起。
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公开(公告)号：US20110031830A1
公开(公告)日：2011-02-10
申请号：US12538556
申请日：2009-08-10
Applicant: John Christen Oleson , Andrew David Cook
Inventor： John Christen Oleson , Andrew David Cook
IPC: H02K5/12
Abstract: An electric motor is provided that is configured for operation in hazardous or other hazardous environments. The electric motor includes a housing for a rotor and a stator. The housing includes a pair of end caps and a casing positioned therebetween. The end caps and the casing are held together using internal tie bars extending between and connected to the end caps.
Abstract translation: 提供了一种电动机，配置用于在危险或其他危险环境中运行。 电动机包括用于转子和定子的壳体。 壳体包括一对端盖和位于其间的壳体。 端盖和外壳使用在端盖之间延伸并连接到端盖的内部连接杆保持在一起。
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公开(公告)号：US20110287027A1
公开(公告)日：2011-11-24
申请号：US13140839
申请日：2009-12-21
Applicant: John Allan Hamilton , Andrew David Cook
Inventor： John Allan Hamilton , Andrew David Cook
IPC: A61K39/395 , A61P29/00
CPC classification number: C07K16/243 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/56 , C07K2317/565 , C07K2317/76
Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
Abstract translation: 本发明一般涉及治疗和预防疼痛的方法。 根据本发明，提出GM-CSF的拮抗剂对于疼痛的治疗是有效的。 GM-CSF的拮抗剂包括但不限于对GM-CSF或GM-CSF受体特异的抗体。 本发明还提供了可用于在某些疾病模型中测试拮抗剂的转基因动物，例如GM-CSF敲除小鼠。
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公开(公告)号：US07307055B2
公开(公告)日：2007-12-11
申请号：US10501177
申请日：2003-01-16
Applicant: Andrew David Cook , Edward Mathew Cooney , Michael Vincent Monticello
Inventor： Andrew David Cook , Edward Mathew Cooney , Michael Vincent Monticello
CPC classification number: A47L17/08 , A47L13/17 , C11D1/143 , C11D1/72 , C11D1/83 , C11D3/14 , C11D3/222 , C11D17/049
Abstract: Disclosed herein is a cleaning article as an article of manufacture which includes a substrate onto which a cleaning composition is partially impregnated, leaving a portion of the substrate not impregnated with the composition. The impregnated part or side of the substrate is used to clean surfaces, especially vitro-ceramic surfaces while the unimpregnated part or side of the substrate is then used to dry and buff the cleaned surface.
Abstract translation: 本文公开了作为制品的清洁制品，其包括其上部分浸渍有清洁组合物的基底，使基底的一部分未浸渍该组合物。 衬底的浸渍部分或侧面用于清洁表面，特别是体外陶瓷表面，同时衬底的未浸渍部分或侧面用于干燥和抛光清洁表面。
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