公开(公告)号：US20050095708A1

公开(公告)日：2005-05-05

申请号：US10841907

申请日：2004-05-07

申请人： Martin Pera ,  Andrew Laslett ,  Susan Hawes ,  Tomonobu Gion

发明人： Martin Pera ,  Andrew Laslett ,  Susan Hawes ,  Tomonobu Gion

IPC分类号： A61K35/12 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/08

CPC分类号： C12N5/0603 ,  A61K35/12 ,  C12N5/0606 ,  C12N2500/25 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/115 ,  C12N2502/13 ,  C12N2506/02

摘要： A sub-population of HES cells is identified which is positive for specific HES markers. These cell types are identified by expression of particular GCTM-2 antigens. A method based on the identification of GCTM-2 can differentiate between substantially undifferentiated or differentiated cell populations. Spontaneous differentiation often occurs in HES cultures resulting in non-homogeneous cell cultures. The invention also provides further sub populations of cells within differentiated cultures of HES cells that are SCL or epithelial in nature.

摘要翻译： 确定HES细胞的亚群，其对于特异性HES标记物是阳性的。 这些细胞类型通过特定GCTM-2抗原的表达来鉴定。 基于鉴定GCTM-2的方法可以区分基本上未分化或分化的细胞群体。 自发分化通常发生在HES培养物中，导致非均匀的细胞培养。 本发明还提供了在本质上是SCL或上皮的HES细胞的分化培养物中的另外的细胞群。