公开(公告)号：US20050095708A1

公开(公告)日：2005-05-05

申请号：US10841907

申请日：2004-05-07

申请人： Martin Pera ,  Andrew Laslett ,  Susan Hawes ,  Tomonobu Gion

发明人： Martin Pera ,  Andrew Laslett ,  Susan Hawes ,  Tomonobu Gion

IPC分类号： A61K35/12 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/08

CPC分类号： C12N5/0603 ,  A61K35/12 ,  C12N5/0606 ,  C12N2500/25 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/115 ,  C12N2502/13 ,  C12N2506/02

摘要： A sub-population of HES cells is identified which is positive for specific HES markers. These cell types are identified by expression of particular GCTM-2 antigens. A method based on the identification of GCTM-2 can differentiate between substantially undifferentiated or differentiated cell populations. Spontaneous differentiation often occurs in HES cultures resulting in non-homogeneous cell cultures. The invention also provides further sub populations of cells within differentiated cultures of HES cells that are SCL or epithelial in nature.

摘要翻译： 确定HES细胞的亚群，其对于特异性HES标记物是阳性的。 这些细胞类型通过特定GCTM-2抗原的表达来鉴定。 基于鉴定GCTM-2的方法可以区分基本上未分化或分化的细胞群体。 自发分化通常发生在HES培养物中，导致非均匀的细胞培养。 本发明还提供了在本质上是SCL或上皮的HES细胞的分化培养物中的另外的细胞群。

公开(公告)号：US20070218059A1

公开(公告)日：2007-09-20

申请号：US10574885

申请日：2004-10-08

申请人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

发明人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

IPC分类号： A61K39/395 ,  G01N33/53

CPC分类号： C07K16/28 ,  A61K35/407 ,  C07K14/47 ,  C12N5/0672 ,  C12N2503/00 ,  G01N33/56966

摘要： The present invention provides a cell marker that is characterized by binding to a GCTM-5 antibody of active fragment. The cell marker identifies a unique sub-population of stem cells that show characteristics of hepatic or pancreatic stem cells or hepatic or pancreatic progenitor cells. More specifically the marker is an early liver marker, which could prove a useful tool for the isolation and identification of liver and pancreatic progenitors for both diseased adult liver and differentiating human embryonic stem cells.

摘要翻译： 本发明提供了特征在于结合活性片段的GCTM-5抗体的细胞标记物。 细胞标记鉴定出显示肝脏或胰腺干细胞或肝脏或胰腺祖细胞特征的干细胞的独特亚群。 更具体地说，标记物是早期肝脏标记物，其可以证明用于分离和鉴定患病成人肝脏和分化的人类胚胎干细胞的肝脏和胰腺祖细胞的有用工具。

公开(公告)号：US08119774B2

公开(公告)日：2012-02-21

申请号：US10574885

申请日：2004-10-08

申请人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

发明人： Martin Pera ,  Susan Hawes ,  Lincon Stamp ,  Heather Crosby ,  Alastair Strain

IPC分类号： C07K16/00 ,  C12N5/00

CPC分类号： C07K16/28 ,  A61K35/407 ,  C07K14/47 ,  C12N5/0672 ,  C12N2503/00 ,  G01N33/56966

摘要： The present invention provides a cell marker that is characterized by binding to a GCTM-5 antibody of active fragment. The cell marker identifies a unique sub-population of stem cells that show characteristics of hepatic or pancreatic stem cells or hepatic or pancreatic progenitor cells. More specifically the marker is an early liver marker, which could prove a useful tool for the isolation and identification of liver and pancreatic progenitors for both diseased adult liver and differentiating human embryonic stem cells.

摘要翻译： 本发明提供了特征在于结合活性片段的GCTM-5抗体的细胞标记物。 细胞标记鉴定出显示肝脏或胰腺干细胞或肝脏或胰腺祖细胞特征的干细胞的独特亚群。 更具体地说，标记物是早期肝脏标记物，其可以证明用于分离和鉴定患病成人肝脏和分化的人类胚胎干细胞的肝脏和胰腺祖细胞的有用工具。