公开(公告)号：US20120032576A1

公开(公告)日：2012-02-09

申请号：US13204008

申请日：2011-08-05

Applicant: Roger Philips Shurter ,  David James Devlin ,  Nathan Andrew Moody ,  Jose Martin Taccetti ,  Steven John Russell

Inventor： Roger Philips Shurter ,  David James Devlin ,  Nathan Andrew Moody ,  Jose Martin Taccetti ,  Steven John Russell

IPC: H01J9/02

CPC classification number: H01J1/304 ,  H01J2201/30446 ,  H01J2201/30457 ,  H01J2201/30469

Abstract: An electron source includes a back contact surface having a means for attaching a power source to the back contact surface. The electron source also includes a layer comprising platinum in direct contact with the back contact surface, a composite layer of single-walled carbon nanotubes embedded in platinum in direct contact with the layer comprising platinum. The electron source also includes a nanocrystalline diamond layer in direct contact with the composite layer. The nanocrystalline diamond layer is doped with boron. A portion of the back contact surface is removed to reveal the underlying platinum. The electron source is contained in an evacuable container.

Abstract translation: 电子源包括具有用于将电源附接到后接触表面的装置的后接触表面。 电子源还包括包含与背接触表面直接接触的铂的层，嵌入铂中的与包含铂的层直接接触的单壁碳纳米管的复合层。 电子源还包括与复合层直接接触的纳米晶体金刚石层。 纳米晶金刚石层掺杂硼。 背部接触表面的一部分被去除以露出下面的铂。 电子源包含在可抽真空的容器中。

公开(公告)号：US20090192135A1

公开(公告)日：2009-07-30

申请号：US11887346

申请日：2006-03-28

Applicant: Jason Samuel Simon ,  Maha Chabhar Karnoub ,  Michael E. Severino ,  David James Devlin ,  Andrew Stewart Plump ,  Eric E. Schadt

Inventor： Jason Samuel Simon ,  Maha Chabhar Karnoub ,  Michael E. Severino ,  David James Devlin ,  Andrew Stewart Plump ,  Eric E. Schadt

IPC: A61K31/397 ,  C12Q1/60 ,  C12Q1/68 ,  C40B30/04 ,  C07H21/04

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: The present invention relates to the identification and use of single nucleotide polymorphisms and haplotypes in the Niemann Pick C1-Like 1 (NPC1L1) gene. In particular, methods are provided for correlating NPC1L1 polymorphisms and haplo-types with the responsiveness of a pharmaceutically active compound administered to a human subject. The invention further relates to a method for estimating the responsiveness of a pharmaceutically active compound administered to a human subject which method comprises determining at least one polymorphism in the NPC1L1 gene. The methods are based on determining polymorphisms in the NPC1L1 gene and correlating the responsiveness of a pharmaceutically active compound in the human by reference to one or more polymorphism in NPC1L1. The invention further relates to isolated nucleic acids comprising within their sequence the polymorphisms as defined herein, to nucleic acid primers and oligonucleotide probes capable of hybridizing to such nucleic acids and to a diagnostic kit comprising one or more of such primers and probes for detecting a polymorphism in the NPC1L1 gene.

Abstract translation: 本发明涉及Niemann Pick C1-Like 1（NPC1L1）基因中单核苷酸多态性和单元型的鉴定和应用。 特别地，提供了将NPC1L1多态性和单体类型与施用于人类受试者的药学活性化合物的反应性相关联的方法。 本发明还涉及一种用于估计施用于人受试者的药学活性化合物的反应性的方法，所述方法包括确定NPC1L1基因中的至少一个多态性。 该方法基于确定NPC1L1基因中的多态性，并通过参照NPC1L1中的一个或多个多态性将药物活性化合物在人体中的反应性相关联。 本发明还涉及在其序列中包含本文所定义的多态性的分离的核酸与能够与此类核酸杂交的核酸引物和寡核苷酸探针以及包含一种或多种用于检测多态性的引物和探针的诊断试剂盒 在NPC1L1基因中。

公开(公告)号：US08227985B2

公开(公告)日：2012-07-24

申请号：US13204008

申请日：2011-08-05

Applicant: Roger Philips Shurter ,  David James Devlin ,  Nathan Andrew Moody ,  Jose Martin Taccetti ,  Steven John Russell

Inventor： Roger Philips Shurter ,  David James Devlin ,  Nathan Andrew Moody ,  Jose Martin Taccetti ,  Steven John Russell

IPC: H01J9/02 ,  H01J21/00 ,  H01J5/16 ,  H01J1/34

CPC classification number: H01J1/304 ,  H01J2201/30446 ,  H01J2201/30457 ,  H01J2201/30469

Abstract: An electron source includes a back contact surface having a means for attaching a power source to the back contact surface. The electron source also includes a layer comprising platinum in direct contact with the back contact surface, a composite layer of single-walled carbon nanotubes embedded in platinum in direct contact with the layer comprising platinum. The electron source also includes a nanocrystalline diamond layer in direct contact with the composite layer. The nanocrystalline diamond layer is doped with boron. A portion of the back contact surface is removed to reveal the underlying platinum. The electron source is contained in an evacuable container.

Abstract translation: 电子源包括具有用于将电源附接到后接触表面的装置的后接触表面。 电子源还包括包含与背接触表面直接接触的铂的层，嵌入铂中的与包含铂的层直接接触的单壁碳纳米管的复合层。 电子源还包括与复合层直接接触的纳米晶体金刚石层。 纳米晶金刚石层掺杂硼。 背部接触表面的一部分被去除以露出下面的铂。 电子源包含在可抽真空的容器中。

公开(公告)号：US6037016A

公开(公告)日：2000-03-14

申请号：US77513

申请日：1998-05-29

Applicant: David James Devlin ,  Don Mayo Coates ,  Thomas Arthur Archuleta ,  Robert Steven Barbero

Inventor： David James Devlin ,  Don Mayo Coates ,  Thomas Arthur Archuleta ,  Robert Steven Barbero

IPC: C23C16/26 ,  C23C16/27 ,  C23C16/50 ,  C23C16/505 ,  C23C16/54 ,  D06M10/02 ,  D06M10/06 ,  D06M11/74 ,  D06M101/36 ,  B05D3/06 ,  C23C16/00

CPC classification number: D06M11/74 ,  C23C16/26 ,  C23C16/545 ,  D06M10/025 ,  D06M10/06 ,  D06M2101/36 ,  Y10S427/104

Abstract: A process of coating a non-conductive fiber with diamond-like carbon, including passing a non-conductive fiber between a pair of parallel metal grids within a reaction chamber, introducing a hydrocarbon gas into the reaction chamber, forming a plasma within the reaction chamber for a sufficient period of time whereby diamond-like carbon is formed upon the non-conductive fiber, is provided together with a reactor chamber for deposition of diamond-like carbon upon a non-conductive fiber, including a vacuum chamber, a cathode assembly including a pair of electrically isolated opposingly parallel metal grids spaced apart at a distance of less than about 1 centimeter, an anode, a means of introducing a hydrocarbon gas into said vacuum chamber, and a means of generating a plasma within said vacuum chamber.

Abstract translation: PCT No.PCT / US96 / 18438 Sec。 371日期：1998年5月29日 102（e）日期1998年5月29日PCT 1996年11月18日PCT公布。 公开号WO97 / 20981 日期：1997年6月12日一种用类金刚石碳涂覆非导电纤维的方法，包括使非导电纤维在反应室内的一对平行金属网之间通过，将烃气体引入反应室，形成 在反应室内等离子体足够长的时间，其中在非导电纤维上形成类金刚石碳，与反应室一起设置，用于将金刚石状碳沉积在非导电纤维上，该非导电纤维包括真空室 一个阴极组件，其包括一对间隔开的距离小于约1厘米的电隔离的相对平行的金属栅极，阳极，将烃气体引入所述真空室中的装置，以及在所述真空室内产生等离子体的装置 真空室。

公开(公告)号：US06432537B1

公开(公告)日：2002-08-13

申请号：US09077514

申请日：1998-05-29

Applicant: David James Devlin ,  Don Mayo Coates ,  Thomas Arthur Archuleta

Inventor： David James Devlin ,  Don Mayo Coates ,  Thomas Arthur Archuleta

IPC: H05H124

CPC classification number: D06M10/025 ,  C23C16/26 ,  D06M10/06 ,  D06M11/74 ,  D06M2101/36 ,  Y10S427/104 ,  Y10T428/292 ,  Y10T428/30

Abstract: A process for improving the mechanical properties, particularly the flexural rigidity, of aramid fibers by directly depositing a diamond-like-carbon coating onto the surface of the fibers is disclosed. Diamond-like-carbon (DLC) coated aramid fibers having increased flexural rigidity are also disclosed. DLC coated aramid fibers show an increase in flexural rigidity and suppression of low yielding behavior when compared to uncoated aramid fibers.

Abstract translation: 公开了通过在金属纤维的表面上直接沉积类金刚石碳涂层来提高芳族聚酰胺纤维的机械性能，特别是弯曲刚度的方法。 还公开了具有增加的抗弯刚度的金刚石碳（DLC）涂覆的芳族聚酰胺纤维。 与未涂布的芳族聚酰胺纤维相比，DLC涂覆的芳族聚酰胺纤维显示出抗弯刚度的增加和低屈服行为的抑制。