公开(公告)号：US20070036806A1

公开(公告)日：2007-02-15

申请号：US10558627

申请日：2004-06-10

申请人： Wolfgang Glaesner ,  Rohn Millican ,  Andrew Vick

发明人： Wolfgang Glaesner ,  Rohn Millican ,  Andrew Vick

IPC分类号： A61K39/395 ,  C07K16/46 ,  C07K14/605

CPC分类号： C07K16/26 ,  A61K38/00 ,  C07K14/503 ,  C07K14/605 ,  C07K2319/30

摘要： The invention provides specific GLP-1 analogs fused to specific IgG4-Fc derivatives. These fusion proteins have an increased half-life, decreased immunogenicity, and reduce effector activity. The fusion proteins are useful in treating diabetes, obesity, irritable bowel syndrome and other conditions that would be benefited by lowering plasma glucose, inhibiting gastric and/or intestinal motility and inhibiting gastric and/or intestinal emptying, or inhibiting food intake.

摘要翻译： 本发明提供了与特异性IgG4-Fc衍生物融合的特异性GLP-1类似物。 这些融合蛋白具有增加的半衰期，免疫原性降低，并降低效应子活性。 融合蛋白可用于治疗糖尿病，肥胖症，肠易激综合征和其它通过降低血浆葡萄糖，抑制胃和/或肠运动并抑制胃和/或肠排空或抑制食物摄取而受益的病症。

公开(公告)号：US20070253966A1

公开(公告)日：2007-11-01

申请号：US10558862

申请日：2004-06-10

申请人： Wolfgang Glaesner ,  Rohn Millican Jr ,  Yu Tian ,  Sheng-Hung Tschang ,  Andrew Vick

发明人： Wolfgang Glaesner ,  Rohn Millican Jr ,  Yu Tian ,  Sheng-Hung Tschang ,  Andrew Vick

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/04 ,  C12N5/06 ,  C07K16/46

CPC分类号： C07K16/26 ,  A61K38/00 ,  C07K14/50 ,  C07K14/503 ,  C07K14/605 ,  C07K2319/30 ,  C07K2319/75

摘要： The invention provides active therapeutic peptides fused to specific IgG4-Fc derivatives. These fusion proteins have an increased half-life, reduced half antibody formation, and reduced effector activity, while not being immnunogenic. The fusion proteins are useful in treating human diseases as well as a variety of other conditions or disorders.

摘要翻译： 本发明提供与特异性IgG4-Fc衍生物融合的活性治疗性肽。 这些融合蛋白具有增加的半衰期，减少半抗体形成和降低的效应子活性，而不是无生成的。 融合蛋白可用于治疗人类疾病以及各种其他病症或障碍。

公开(公告)号：US4052596A

公开(公告)日：1977-10-04

申请号：US535495

申请日：1974-12-23

申请人： Howard Andrew Vick

发明人： Howard Andrew Vick

IPC分类号： G01N15/12 ,  G01N33/483 ,  H03K21/04

CPC分类号： G01N15/1227

摘要： A hematology analyzer provides a pulse signal in which the number of pulses manifests the number of blood cells in a sample volume of blood and the magnitude of each pulse manifests the size of each such blood cell. The analyzer also provides an analog voltage manifesting the hemoglobin content of the blood sample. Means responsive to the pulse signal provide an analog voltage manifesting the hematocrit of the blood sample and an analog voltage manifesting the number of cells. An analog-to-digital converter is switchably responsive to the analog hemoglobin, hematocrit and cell count signals to provide required ratios reflecting the mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration of the blood sample.

摘要翻译： 在血液分析仪中，检测在计数期间指示样品中的红细胞的脉冲峰。 峰值检测装置产生连接到栅极装置的栅极信号，其将峰值的时间附近的每个脉冲的一部分耦合到积分装置。 在积分装置中累积的水平指示总细胞体积，因此指示已知样品体积的血细胞比容。

公开(公告)号：US4115864A

公开(公告)日：1978-09-19

申请号：US791559

申请日：1977-04-27

申请人： Howard Andrew Vick ,  Donald B. Johnson

发明人： Howard Andrew Vick ,  Donald B. Johnson

IPC分类号： A61B5/0424 ,  G06F17/00 ,  G08B21/00

CPC分类号： A61B5/0424

摘要： A fail safe detector in a cardiac monitoring system provides an alarm to indicate failure of the system to respond to cardiac waveforms supplied thereto from cardiac waveform sources. A time out circuit will produce the alarm if not periodically reset by pulses produced in response to measurement of cardiac waveforms. Means are provided for sensing whether cardiac waveforms are received from the sources to provide an alternate means of triggering periodic reset signals when no waveforms are received from the sources to prevent false alarms.

摘要翻译： 心脏监测系统中的故障安全检测器提供警报以指示系统对心脏波形源提供的心脏波形的响应。 超时电路将产生报警，如果不是响应于心脏波形的测量而产生的脉冲周期性地复位。 提供了用于感测是否从源接收心脏波形的装置，以提供当不从源接收到波形以防止假警报时触发周期性复位信号的替代手段。

公开(公告)号：US4086631A

公开(公告)日：1978-04-25

申请号：US752015

申请日：1976-12-20

申请人： Howard Andrew Vick

发明人： Howard Andrew Vick

IPC分类号： G01N15/12 ,  G01N33/483 ,  G01N15/08 ,  G06M11/04

CPC分类号： G01N15/1227

摘要： In a hematology analyzer, peaks of pulses indicative of red blood cells in a sample during a count are detected. Peak detecting means produce a gate signal connected to gate means which couple a portion of each pulse in the time vicinity of its peak to integration means. The level accumulated in the integration means is indicative of total cell volume, and hence indicative of hematocrit for a known sample volume.