公开(公告)号：US20120122186A1

公开(公告)日：2012-05-17

申请号：US13059513

申请日：2009-09-27

申请人： Beata Weber-Dabrowska ,  Andrzej Górski ,  Ryszard Miedzybrodzki

发明人： Beata Weber-Dabrowska ,  Andrzej Górski ,  Ryszard Miedzybrodzki

IPC分类号： C12N7/00 ,  A61P31/04

CPC分类号： A61K35/76 ,  C12N7/00 ,  C12N2795/00021 ,  C12N2795/00032

摘要： Novel bacteriophage strains are disclosed and their use in the production of preparations for use in the treatment of bacterial infections, particularly with drug resistant strains of bacteria of the genus Enterococcus, particularly those belonging to the species Enterococcus faecalis.

摘要翻译： 公开了新型噬菌体菌株及其在生产用于治疗细菌感染的制剂中的用途，特别是肠球菌属的耐药性菌株，特别是属于粪肠球菌的菌株。

公开(公告)号：US09238798B2

公开(公告)日：2016-01-19

申请号：US13059815

申请日：2009-10-29

申请人： Ewa Zuziak ,  Andrzej Gamian ,  Andrzej Górski ,  Tomasz Lipiński

发明人： Ewa Zuziak ,  Andrzej Gamian ,  Andrzej Górski ,  Tomasz Lipiński

IPC分类号： A61K35/13 ,  C12N7/00

CPC分类号： C12N7/00 ,  A61K35/13 ,  C12N2795/10051 ,  C12N2795/10151

摘要： The subject the present invention is a method of producing a pharmacologically stable form of purified and lyophilised bacteriophage preparations of increased stability and antibacterial activity, characterized in that phages produced from a bacterial lysate, for example by ultrafiltration on ultrafiltration membranes, containing a high molecular weight preparation of purified phages is stabilised most preferably with a probiotic extract in the presence or absence of neutral salts and/or organic solvents, lyophilised, characterised via HPLC chromatography, by SDS-PAGE, and bacterial lysis biological assays, and then stored under a vacuum, where the active lyophilisate is destined for phage therapy of infections and tumors.

摘要翻译： 本发明的主题是制备具有增加的稳定性和抗菌活性的纯化和冻干的噬菌体制剂的药理稳定形式的方法，其特征在于从细菌裂解物产生的噬菌体，例如通过在超滤膜上超滤，含有高分子量 纯化噬菌体的制备在存在或不存在中性盐和/或有机溶剂的情况下最优选用益生菌提取物稳定，冻干，通过HPLC色谱法，通过SDS-PAGE表征，细菌裂解生物测定法，然后在真空下储存 ，其中活性冻干物用于感染和肿瘤的噬菌体治疗。

公开(公告)号：US08440446B2

公开(公告)日：2013-05-14

申请号：US13059513

申请日：2009-09-27

申请人： Beata Weber-Dabrowska ,  Andrzej Górski ,  Ryszard Miedzybrodzki

发明人： Beata Weber-Dabrowska ,  Andrzej Górski ,  Ryszard Miedzybrodzki

IPC分类号： C12N7/00 ,  A01N63/00

CPC分类号： A61K35/76 ,  C12N7/00 ,  C12N2795/00021 ,  C12N2795/00032

摘要： Novel bacteriophage strains are disclosed and their use in the production of preparations for use in the treatment of bacterial infections, particularly with drug resistant strains of bacteria of the genus Enterococcus, particularly those belonging to the species Enterococcus faecalis.

摘要翻译： 公开了新的噬菌体菌株及其在生产用于治疗细菌感染的制剂中的用途，特别是肠球菌属的耐药性菌株，特别是属于粪肠球菌的菌株。