利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.025 秒)

    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
    2.
    发明授权
    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
    低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用

    公开(公告)号：US07402395B2

    公开(公告)日：2008-07-22

    申请号：US10671242

    申请日：2003-09-24

    申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    IPC分类号： G01N33/53 ,  C07K14/00

    CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

    摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

    摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
    3.
    发明授权
    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
    低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用

    公开(公告)号：US07807384B2

    公开(公告)日：2010-10-05

    申请号：US12137832

    申请日：2008-06-12

    申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    IPC分类号： G01N33/53 ,  C07K1/00

    CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

    摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

    摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
    4.
    发明授权
    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
    低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用

    公开(公告)号：US07244410B2

    公开(公告)日：2007-07-17

    申请号：US10616187

    申请日：2003-07-09

    申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    IPC分类号： A61K51/10 ,  G01N33/53

    CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

    摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

    摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。

    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
    6.
    发明授权
    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
    低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用

    公开(公告)号：US06632923B1

    公开(公告)日：2003-10-14

    申请号：US09616289

    申请日：2000-07-14

    申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    IPC分类号： C07K1400

    CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

    摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

    摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供了药物组合物和疫苗组合物

    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
    7.
    发明授权
    Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis 失效
    低密度脂蛋白结合蛋白及其在诊断和治疗动脉粥样硬化中的应用

    公开(公告)号：US06355451B1

    公开(公告)日：2002-03-12

    申请号：US08979608

    申请日：1997-11-26

    申请人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    发明人： Ann M. Lees ,  Robert S. Lees ,  Simon W. Law ,  Anibal A. Arjona

    IPC分类号： C12P2106

    CPC分类号： A61K49/0004 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/323

    摘要： Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

    摘要翻译： 描述了编码能够结合天然和甲基化的LDL（低密度脂蛋白），所述分离的多肽（称为LBP（LDL结合蛋白））及其生物活性片段及其类似物的分离的多核苷酸的分离多核苷酸。 还描述了用于确定动物是否处于动脉粥样硬化风险的方法，用于评估用于治疗动脉粥样硬化的药剂的方法，治疗动脉粥样硬化的方法，以及用于治疗LBP的结构或代谢异常的细胞的方法。 还提供药物组合物和疫苗组合物。