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    Suturing apparatus and methods
    1.
    发明申请
    Suturing apparatus and methods 审中-公开
    缝合装置和方法

    公开(公告)号：US20070203507A1

    公开(公告)日：2007-08-30

    申请号：US11511873

    申请日：2006-08-28

    申请人： Glen McLaughlin ,  Imraan Aziz ,  Ron Songer ,  Jeffrey Christian ,  Anil Singhal

    发明人： Glen McLaughlin ,  Imraan Aziz ,  Ron Songer ,  Jeffrey Christian ,  Anil Singhal

    IPC分类号： A61B17/04

    CPC分类号： A61B17/0057 ,  A61B17/0401 ,  A61B17/0625 ,  A61B2017/00637 ,  A61B2017/00663 ,  A61B2017/0417 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0472 ,  A61B2017/0475

    摘要： Embodiments of the invention provide methods and apparatus for suturing tissue penetrations made during minimally invasive surgery. One embodiment of an apparatus for suturing tissue penetrations comprises a shaft, suture capture surface coupled to the shaft, and at least one pair of needles or other penetrating members advanceable from the shaft. The shaft can be detachably coupled to a hand-piece. The surface has a deployed and a non-deployed configuration and is configured to capture a suture in the deployed configuration and retain it in the non-deployed configuration. The surface can be deployed by a frame or other expandable structure. The penetrating members are configured to be coupled to a suture and are advanceable from the shaft by an advancement member or other means to deliver a suture end portion to the deployed surface. Sutures can be contained in a replaceable cartridge detachably coupled to the apparatus.

    摘要翻译： 本发明的实施例提供了用于在微创手术期间缝合组织穿透的方法和装置。 用于缝合组织穿透的装置的一个实施例包括连接到所述轴的轴，缝合线捕获表面以及可从所述轴推进的至少一对针或其它穿透构件。 轴可以可拆卸地联接到手持件。 表面具有已部署和未部署的配置，并配置为捕获部署配置中的缝合线并将其保留在未部署的配置中。 表面可以通过框架或其他可扩展结构来展开。 穿透构件被构造成联接到缝合线并且可以通过前进构件或其它装置从轴前进，以将缝线端部分递送到展开的表面。 缝合线可以容纳在可拆卸地联接到该装置的可替换的盒中。

    Method for the production of monoclonal antibodies directed to tumor-associated gangliosides and fucogangliosides
    4.
    发明授权
    Method for the production of monoclonal antibodies directed to tumor-associated gangliosides and fucogangliosides 失效
    用于产生针对肿瘤相关神经节苷脂和神经节苷脂的单克隆抗体的方法

    公开(公告)号：US5240833A

    公开(公告)日：1993-08-31

    申请号：US787778

    申请日：1991-11-06

    申请人： Edward Nudelman ,  Anil Singhal ,  Henrik Clausen ,  Sen-itiroh Hakomori

    发明人： Edward Nudelman ,  Anil Singhal ,  Henrik Clausen ,  Sen-itiroh Hakomori

    IPC分类号： A61K38/00 ,  C07K16/30 ,  C12P21/08

    CPC分类号： C07K16/30 ,  A61K38/00

    摘要： A method of producing monoclonal antibodies that bind to tumor-associated gangliosides, the method comprising: (1) immunizing a host with tumor cells; (2) boosting the host with a suspension comprising a mixture of tumor cell membrane and at least one purified lactonized tumor-associated ganglioside; (3) boosting the host with an immunogen comprising a lactone of a tumor associated ganglioside adsorbed on or incorporated into a carrier; (4) fusing immunized cells from the host with myeloma cells to form hybridoma cells: (5) selecting hybridoma cells that produce antibody that binds to the ganglioside of step (3); (6) culturing the selected hybridoma cells; and (7) recovering the antibody. Hybridomas and monoclonal antibodies produced by the above-described method. A passive immunization method for treatment of tumors containing gangliosides comprising administering to a subject: (A) a pharmaceutically effective amount of an antibody produced by the above described method. A method for detecting tumors containing gangliosides comprising: (A) contacting a test sample with an antibody produced by the above described method; and (B) assaying for the specific binding of the antibody to antigen in the test sample.

    摘要翻译： 一种产生与肿瘤相关神经节苷脂结合的单克隆抗体的方法，所述方法包括：（1）用肿瘤细胞免疫宿主; （2）用包含肿瘤细胞膜和至少一种经内化的内源性肿瘤相关神经节苷脂的混合物的悬浮液加强宿主; （3）用包含吸附在载体上或结合到载体中的肿瘤相关神经节苷脂的内酯的免疫原来加强宿主; （4）将来自宿主的免疫细胞与骨髓瘤细胞融合以形成杂交瘤细胞：（5）选择产生与步骤（3）的神经节苷脂结合的抗体的杂交瘤细胞; （6）培养所选择的杂交瘤细胞; 和（7）回收抗体。 通过上述方法制备的杂交瘤和单克隆抗体。 一种用于治疗含有神经节苷脂的肿瘤的被动免疫方法，包括对受试者施用：（A）药学有效量的由上述方法产生的抗体。 一种用于检测含有神经节苷脂的肿瘤的方法，包括：（A）使测试样品与通过上述方法产生的抗体接触; 和（B）在测试样品中测定抗体与抗原的特异性结合。

    Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates
    5.
    发明授权
    Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates 失效
    通过用碳水化合物 - 载体缀合物免疫，针对人类癌症相关抗原的单克隆抗体和疫苗开发

    公开(公告)号：US5660834A

    公开(公告)日：1997-08-26

    申请号：US400480

    申请日：1995-03-08

    申请人： Thomas J. Kjeldsen ,  Henrik Clausen ,  Anil Singhal ,  Tatsushi Toyokuni ,  Helio K. Takahashi ,  Sen-Itiroh Hakomori

    发明人： Thomas J. Kjeldsen ,  Henrik Clausen ,  Anil Singhal ,  Tatsushi Toyokuni ,  Helio K. Takahashi ,  Sen-Itiroh Hakomori

    IPC分类号： A61K39/00 ,  C07K14/47 ,  C07K16/30 ,  A61K38/14 ,  A61K39/39 ,  C07K14/82

    CPC分类号： C07K14/4727 ,  A61K39/0011 ,  C07K16/30 ,  A61K2039/55572 ,  A61K2039/6018 ,  A61K2039/6081 ,  A61K2039/645

    摘要： A vaccine and method to prevent growth and replication of cancer cells that express a core structure of a mucin-type glycoprotein is disclosed. The vaccine comprises: (a) a pharmaceutically effective amount of an antigen comprising a purified mucin-type glycoprotein or a chemically synthesized mucin-type glycoprotein carbohydrate determinant conjugated to a carrier peptide or macromolecule, wherein said mucin-type glycoprotein expresses or carries the core structure of a mucin-type glycoprotein expressed on said cancer cells; and (b) a pharmaceutically acceptable carrier including natural or synthetic adjuvants. The method comprises administering the above-described vaccine to a host. A medicament and method for treating cancer wherein the cancer cells express a core structure of a mucin-type glycoprotein is disclosed. The medicament comprises: (a) a pharmaceutically effective amount of an anti-cancer antibody or fragment comprising a binding site thereof, said anti-cancer antibody having been produced against a purified core structure of a mucin-type glycoprotein; and (b) a pharmaceutically acceptable carrier, diluent or excipient. The method comprises administering the above-described medicament to a host.

    摘要翻译： 公开了一种用于预防表达粘蛋白型糖蛋白的核心结构的癌细胞的生长和复制的疫苗和方法。 疫苗包含：（a）药学有效量的抗原，其包含与载体肽或大分子缀合的纯化的粘蛋白型糖蛋白或化学合成的粘蛋白型糖蛋白碳水化合物决定簇，其中所述粘蛋白型糖蛋白表达或携带核心 在所述癌细胞上表达的粘蛋白型糖蛋白的结构; 和（b）包括天然或合成佐剂的药学上可接受的载体。 该方法包括将上述疫苗给予宿主。 公开了一种治疗癌症的药物和方法，其中癌细胞表达粘蛋白型糖蛋白的核心结构。 药物包括：（a）药学有效量的抗癌抗体或包含其结合位点的片段，所述抗癌抗体是针对粘蛋白型糖蛋白的纯化核心结构产生的; 和（b）药学上可接受的载体，稀释剂或赋形剂。 该方法包括将上述药物施用于宿主。

    Blood treatment method
    6.
    发明授权
    Blood treatment method 失效
    血液处理方法

    公开(公告)号：US5418129A

    公开(公告)日：1995-05-23

    申请号：US803065

    申请日：1991-12-06

    申请人： Edward Nudelman ,  Anil Singhal ,  Henrik Clausen ,  Sen-itiroh Hakomori ,  Kazuo Muroi ,  Toshio Suda ,  Hisao Nojiri

    发明人： Edward Nudelman ,  Anil Singhal ,  Henrik Clausen ,  Sen-itiroh Hakomori ,  Kazuo Muroi ,  Toshio Suda ,  Hisao Nojiri

    IPC分类号： A61K38/00 ,  C07K16/30 ,  C12P21/08 ,  A01N1/02 ,  A61K39/395 ,  C07K15/28

    CPC分类号： C07K16/30 ,  A61K38/00

    摘要： A method of producing monoclonal antibodies that bind to tumor-associated gangliosides, the method comprising: (1) immunizing a host with tumor cells; (2) boosting the host with a suspension comprising a mixture of tumor cell membrane and at least one purified lactonized tumor-associated ganglioside; (3) boosting the host with an immunogen comprising a lactone of a tumor associated ganglioside adsorbed on or incorporated into a carrier; (4) fusing immunized cells from the host with myeloma cells to form hybridoma cells; (5) selecting hybridoma cells that produce antibody that binds to the ganglioside of step (3); (6) culturing the selected hybridoma cells; and (7) recovering the antibody.

    摘要翻译： 一种产生与肿瘤相关神经节苷脂结合的单克隆抗体的方法，所述方法包括：（1）用肿瘤细胞免疫宿主; （2）用包含肿瘤细胞膜和至少一种经内化的内源性肿瘤相关神经节苷脂的混合物的悬浮液加强宿主; （3）用包含吸附在载体上或结合到载体中的肿瘤相关神经节苷脂的内酯的免疫原来加强宿主; （4）将来自宿主的免疫细胞与骨髓瘤细胞融合以形成杂交瘤细胞; （5）选择产生与步骤（3）的神经节苷脂结合的抗体的杂交瘤细胞; （6）培养所选择的杂交瘤细胞; 和（7）回收抗体。

    Intrusion detection system and network flow director method
    8.
    发明授权
    Intrusion detection system and network flow director method 有权
    入侵检测系统和网络流量控制器方法

    公开(公告)号：US07587762B2

    公开(公告)日：2009-09-08

    申请号：US10637431

    申请日：2003-08-08

    申请人： Anil Singhal ,  Dionisio Lobo

    发明人： Anil Singhal ,  Dionisio Lobo

    IPC分类号： G06F7/04 ,  G06F11/30

    CPC分类号： H04L63/1408

    摘要： A system and related methods are disclosed for detecting the occurrence of an intrusion attack. A network device, such a probe, monitors traffic on a first network and converts the traffic to a format that is suitable for transmission on a second network. The converted traffic is forwarded to an intrusion detection system for further processing. Prior to transmission, the converted data may be filtered to remove data that is not useful in detecting an intrusion attack.

    摘要翻译： 公开了一种用于检测入侵攻击的发生的系统和相关方法。 诸如探测器的网络设备监视第一网络上的流量，并将流量转换为适合于在第二网络上传输的格式。 转换的流量被转发到入侵检测系统进行进一步处理。 在传输之前，转换的数据可以被过滤以去除在检测入侵攻击中无效的数据。