利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.027 秒)

    Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates
    3.
    发明授权
    Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with carbohydrate-carrier conjugates 失效
    通过用碳水化合物 - 载体缀合物免疫，针对人类癌症相关抗原的单克隆抗体和疫苗开发

    公开(公告)号：US5660834A

    公开(公告)日：1997-08-26

    申请号：US400480

    申请日：1995-03-08

    申请人： Thomas J. Kjeldsen ,  Henrik Clausen ,  Anil Singhal ,  Tatsushi Toyokuni ,  Helio K. Takahashi ,  Sen-Itiroh Hakomori

    发明人： Thomas J. Kjeldsen ,  Henrik Clausen ,  Anil Singhal ,  Tatsushi Toyokuni ,  Helio K. Takahashi ,  Sen-Itiroh Hakomori

    IPC分类号： A61K39/00 ,  C07K14/47 ,  C07K16/30 ,  A61K38/14 ,  A61K39/39 ,  C07K14/82

    CPC分类号： C07K14/4727 ,  A61K39/0011 ,  C07K16/30 ,  A61K2039/55572 ,  A61K2039/6018 ,  A61K2039/6081 ,  A61K2039/645

    摘要： A vaccine and method to prevent growth and replication of cancer cells that express a core structure of a mucin-type glycoprotein is disclosed. The vaccine comprises: (a) a pharmaceutically effective amount of an antigen comprising a purified mucin-type glycoprotein or a chemically synthesized mucin-type glycoprotein carbohydrate determinant conjugated to a carrier peptide or macromolecule, wherein said mucin-type glycoprotein expresses or carries the core structure of a mucin-type glycoprotein expressed on said cancer cells; and (b) a pharmaceutically acceptable carrier including natural or synthetic adjuvants. The method comprises administering the above-described vaccine to a host. A medicament and method for treating cancer wherein the cancer cells express a core structure of a mucin-type glycoprotein is disclosed. The medicament comprises: (a) a pharmaceutically effective amount of an anti-cancer antibody or fragment comprising a binding site thereof, said anti-cancer antibody having been produced against a purified core structure of a mucin-type glycoprotein; and (b) a pharmaceutically acceptable carrier, diluent or excipient. The method comprises administering the above-described medicament to a host.

    摘要翻译： 公开了一种用于预防表达粘蛋白型糖蛋白的核心结构的癌细胞的生长和复制的疫苗和方法。 疫苗包含：（a）药学有效量的抗原，其包含与载体肽或大分子缀合的纯化的粘蛋白型糖蛋白或化学合成的粘蛋白型糖蛋白碳水化合物决定簇，其中所述粘蛋白型糖蛋白表达或携带核心 在所述癌细胞上表达的粘蛋白型糖蛋白的结构; 和（b）包括天然或合成佐剂的药学上可接受的载体。 该方法包括将上述疫苗给予宿主。 公开了一种治疗癌症的药物和方法，其中癌细胞表达粘蛋白型糖蛋白的核心结构。 药物包括：（a）药学有效量的抗癌抗体或包含其结合位点的片段，所述抗癌抗体是针对粘蛋白型糖蛋白的纯化核心结构产生的; 和（b）药学上可接受的载体，稀释剂或赋形剂。 该方法包括将上述药物施用于宿主。

    Cyclooxygenase-2 selective agents useful as imaging probes and related methods
    6.
    发明授权
    Cyclooxygenase-2 selective agents useful as imaging probes and related methods 失效
    可用作成像探针和相关方法的环氧合酶-2选择剂

    公开(公告)号：US07329401B2

    公开(公告)日：2008-02-12

    申请号：US10341316

    申请日：2003-01-10

    申请人： Tatsushi Toyokuni ,  Nagichettiar Satyamurthy ,  Harvey R. Herschman ,  Michael E. Phelps ,  Jorge R. Barrio

    发明人： Tatsushi Toyokuni ,  Nagichettiar Satyamurthy ,  Harvey R. Herschman ,  Michael E. Phelps ,  Jorge R. Barrio

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/10 ,  A61K51/0453

    摘要： This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.

    摘要翻译： 本发明提供了新的环加氧酶-2选择剂，其特别可用作非侵入性成像技术如PET和SPECT中的成像探针。 优选的环氧合酶-2选择剂以比常规环加氧酶-2抑制剂更强的效力和特异性抑制环氧合酶-2活性。 本发明的其它方面包括包含环加氧酶-2选择剂的药物组合物以及用于检测和/或抑制环氧合酶-2的方法。 这些方法对于诊断和治疗诸如炎症的疾病特别有用，其特征在于环氧合酶-2水平升高。