公开(公告)号：US20050042272A1

公开(公告)日：2005-02-24

申请号：US10502333

申请日：2003-03-13

申请人： Yafei Hou ,  Du-Hwei Hsu ,  Anita Mehta-Damani ,  Henry Lamparski ,  Redro Paz ,  Jean-Bernard Le Pecq

发明人： Yafei Hou ,  Du-Hwei Hsu ,  Anita Mehta-Damani ,  Henry Lamparski ,  Redro Paz ,  Jean-Bernard Le Pecq

IPC分类号： C12N5/02 ,  A61K35/26 ,  A61K39/00 ,  A61K39/29 ,  A61K39/39 ,  A61K45/00 ,  C07K14/18 ,  C12N5/0783 ,  C12N5/0784 ,  C12N5/10 ,  A61K9/127 ,  C12P7/64 ,  A61K38/20

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/55555 ,  C12N5/0636 ,  C12N5/0639 ,  C12N2500/14 ,  C12N2501/20 ,  C12N2501/515 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2770/24222 ,  C12N2770/24234

摘要： The present invention relates to compositions comprising vesicles released from activated T lymphocytes, as well as to methods for their production and uses. Said vesicles contain a set of bioactive molecules which confer remarkable properties, such as antigen recognition, antigen presentation and other regulatory and effector functions. This invention also relates to methods for transferring or delivering antigenic molecules (e.g., peptides, peptide/MHC complexes, TCR or subunit thereof, etc.) to antigen presenting cells (APCs) using said vesicles, to induce specific immune responses, particularly specific CTL responses. The invention further relates to methods of delivering molecules selectively or specifically to target cells using said vesicles.

摘要翻译： 本发明涉及包含从活化的T淋巴细胞释放的囊泡的组合物，以及其生产和用途的方法。 所述囊泡含有一组生物活性分子，其具有显着的性质，例如抗原识别，抗原呈递和其它调节和效应子功能。 本发明还涉及使用所述囊泡将抗原分子（例如肽，肽/ MHC复合物，TCR或其亚基等）转移或递送至抗原呈递细胞（APC）以诱导特异性免疫应答，特别是特异性CTL 回应。 本发明还涉及使用所述囊泡选择性地或特异性地递送靶向细胞的方法。