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    ARTIFICIAL BONE IMPLANTS, OR BONE GRAFTS, OF POLYMERIC COMPOSITES WITH BONE FORMING PROPERTIES
    2.
    发明申请
    ARTIFICIAL BONE IMPLANTS, OR BONE GRAFTS, OF POLYMERIC COMPOSITES WITH BONE FORMING PROPERTIES 有权
    具有骨形成特性的聚合物复合材料人造骨植入物

    公开(公告)号：US20140348773A1

    公开(公告)日：2014-11-27

    申请号：US14353486

    申请日：2011-10-26

    申请人： Dirk Wybe Grijpma ,  Rudolf Robert Maria Bos ,  Anne Cornelis Van Leeuwen

    发明人： Dirk Wybe Grijpma ,  Rudolf Robert Maria Bos ,  Anne Cornelis Van Leeuwen

    IPC分类号： A61L27/46 ,  A61L27/58 ,  A61L27/18 ,  A61L27/54

    CPC分类号： A61L27/46 ,  A61L24/0063 ,  A61L24/0084 ,  A61L27/18 ,  A61L27/425 ,  A61L27/54 ,  A61L27/58 ,  A61L31/123 ,  A61L31/127 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2300/60 ,  A61L2430/02 ,  C08L67/04

    摘要： The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present invention further relates to polymeric composites provided by the present method and the use of thereof for bone implants, or grafts, specifically the use thereof for orbital floor reconstruction. Specifically, the present invention relates to methods for providing a composite with bone forming properties, the method comprises the steps of: a) providing a liquid, or liquefied, polymeric composition of homopolymers or copolymers of 1,3-trimethylene carbonate (TMC); b) adding to said liquid, or liquefied, polymeric composition one or more agents with osteogenic and/or osteoinductive and/or osteoconductive properties thereby providing a dispersion of said agents in said liquid or liquefied polymeric composition; and c) crosslinking the product obtained, thereby providing a composite with bone forming properties.

    摘要翻译： 本发明涉及用于提供具有骨形成的聚合物复合物的方法，例如具有成骨和/或骨诱导和/或骨传导性质。 本发明还涉及通过本方法提供的聚合物复合材料及其用于骨植入物或移植物的具体用途，用于轨道底层重建。 具体地说，本发明涉及提供具有骨形成特性的复合材料的方法，该方法包括以下步骤：a）提供1,3-三亚甲基碳酸酯（TMC）的均聚物或共聚物的液体或液化的聚合物组合物; b）向所述液体或液化的聚合物组合物中加入一种或多种具有成骨和/或骨诱导和/或骨传导性质的试剂，从而提供所述药物在所述液体或液化聚合物组合物中的分散体; 和c）使获得的产物交联，从而提供具有骨形成性质的复合物。