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公开(公告)号：US08540813B2
公开(公告)日：2013-09-24
申请号：US13000883
申请日：2009-06-23
申请人： Anne Grosset , Olivier Lefèbvre , Christophe Schaller , Nicolas Trachsel , Patrick Magnin , Patrick Veya
发明人： Anne Grosset , Olivier Lefèbvre , Christophe Schaller , Nicolas Trachsel , Patrick Magnin , Patrick Veya
CPC分类号： C09D11/102
摘要： An ink for the engraved copperplate intaglio printing inks is disclosed, which comprises high-molecular-weight dendritic polymer as a binder component. Inks comprising such polymer can be formulated so as to contain a significantly reduced amount of organic solvent (volatile organic components, VOC) while still being in the appropriate viscosity range required by the intaglio printing process. The printed and cured intaglio ink of the present invention has improved chemical and mechanical resistance properties.
摘要翻译： 公开了一种用于雕刻铜版凹版印刷油墨的油墨，其包含作为粘合剂组分的高分子量树枝状聚合物。 包含这种聚合物的油墨可以配制成含有显着减少量的有机溶剂（挥发性有机成分，VOC），同时仍处于凹版印刷方法所需的适当粘度范围。 本发明的印刷和固化的凹版油墨具有改善的化学和机械阻力性能。
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公开(公告)号：US20100267151A1
公开(公告)日：2010-10-21
申请号：US12726941
申请日：2010-03-18
申请人： Cindy Orser , Anne Grosset , Eugene A. Davidson
发明人： Cindy Orser , Anne Grosset , Eugene A. Davidson
IPC分类号： G01N33/68
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
摘要翻译： 用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。 该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。 相互作用催化探针转化为主要的β片段构象，并允许探针结合异常的蛋白质颗粒。 这反过来又催化与测试样品结合探针相关联的信号的传播。 因此，即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。 肽探针可以设计成结合所需的肽序列，或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。
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公开(公告)号：US20080171341A1
公开(公告)日：2008-07-17
申请号：US11979226
申请日：2007-10-31
申请人： Cindy Orser , Anne Grosset , Eugene A. Davidson
发明人： Cindy Orser , Anne Grosset , Eugene A. Davidson
CPC分类号： G01N33/6896 , C07K14/4711 , G01N33/542 , G01N33/582 , G01N2800/2828
摘要： The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.
摘要翻译： 本发明提供用于检测样品中构象改变的蛋白质和朊病毒的方法和试剂盒。 在一个实施方案中，构象改变的蛋白质和朊病毒与淀粉样变性疾病相关。
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公开(公告)号：US20050026165A1
公开(公告)日：2005-02-03
申请号：US10728246
申请日：2003-12-04
申请人： Cindy Orser , Anne Grosset , Eugene Davidson
发明人： Cindy Orser , Anne Grosset , Eugene Davidson
IPC分类号： C07K14/47 , G01N20060101 , G01N33/483 , G01N33/68 , C12Q1/68 , G01N33/53 , G01N33/543
CPC分类号： G01N33/6896 , C07K14/4711 , G01N33/542 , G01N33/582 , G01N2800/2828
摘要： The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.
摘要翻译： 本发明提供用于检测样品中构象改变的蛋白质和朊病毒的方法和试剂盒。 在一个实施方案中，构象改变的蛋白质和朊病毒与淀粉样变性疾病相关。
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公开(公告)号：US20060286672A1
公开(公告)日：2006-12-21
申请号：US10494906
申请日：2002-05-30
申请人： Cindy Orser , Anne Grosset , Eugene Davidson
发明人： Cindy Orser , Anne Grosset , Eugene Davidson
IPC分类号： G01N33/50
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
摘要翻译： 用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。 该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。 相互作用催化探针转化为主要的β片段构象，并允许探针结合异常的蛋白质颗粒。 这反过来，催化与测试样品结合探针相关联的信号的传播。 因此，即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。 肽探针可以设计成结合所需的肽序列，或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。
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公开(公告)号：US20110109076A1
公开(公告)日：2011-05-12
申请号：US13000883
申请日：2009-06-23
申请人： Anne Grosset , Olivier Lefèbvre , Christophe Schaller , Nicolas Trachsel , Patrick Magnin , Patrick Veya
发明人： Anne Grosset , Olivier Lefèbvre , Christophe Schaller , Nicolas Trachsel , Patrick Magnin , Patrick Veya
CPC分类号： C09D11/102
摘要： An ink for the engraved copperplate intaglio printing Hyperbranched polyesters inks is disclosed, which comprises high-molecular-weight dendritic polymer as a binder component. Inks comprising such polymer can be formulated so as to contain a significantly reduced amount of organic solvent (volatile organic components, VOC) whilst still being in the appropriate viscosity range required by the intaglio printing process. The printed and cured intaglio ink of the present invention has improved chemical and mechanical resistance properties.
摘要翻译： 用于雕刻铜版凹版印刷的油墨公开了超支化聚酯油墨，其包含高分子量树枝状聚合物作为粘合剂组分。 包含这种聚合物的油墨可以配制成含有显着减少量的有机溶剂（挥发性有机成分，VOC），同时仍处于凹版印刷过程所需的适当粘度范围内。 本发明的印刷和固化的凹版油墨具有改善的化学和机械阻力性能。
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公开(公告)号：US08062895B2
公开(公告)日：2011-11-22
申请号：US12726941
申请日：2010-03-18
申请人： Cindy Orser , Anne Grosset , Eugene A. Davidson
发明人： Cindy Orser , Anne Grosset , Eugene A. Davidson
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes the transformation of the probe to a predominately beta sheet conformation and allows the probe to bind the abnormal proteinaceous particle. This in turn, catalyzes the propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
摘要翻译： 用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。 该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。 相互作用催化探针转化为主要的β片段构象，并允许探针结合异常的蛋白质颗粒。 这反过来又催化与测试样品结合探针相关联的信号的传播。 因此，即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。 肽探针可以设计成结合所需的肽序列，或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。
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公开(公告)号：US07691639B2
公开(公告)日：2010-04-06
申请号：US10494906
申请日：2002-05-30
申请人： Cindy Orser , Anne Grosset , Eugene A. Davidson
发明人： Cindy Orser , Anne Grosset , Eugene A. Davidson
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.
摘要翻译： 用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。 该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。 相互作用催化探针转化为主要的β片段构象，并允许探针结合异常的蛋白质颗粒。 这反过来，催化与测试样品结合探针相关联的信号的传播。 因此，即使从含有非常低浓度的异常蛋白质颗粒的样品也可以传播信号。 肽探针可以设计成结合所需的肽序列，或者甚至可以基于树枝状大分子结构来控制进一步的聚集体传播。
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公开(公告)号：US07166471B2
公开(公告)日：2007-01-23
申请号：US10161061
申请日：2002-05-30
申请人： Cindy Orser , Anne Grosset , Eugene A Davidson
发明人： Cindy Orser , Anne Grosset , Eugene A Davidson
IPC分类号： G01N33/00
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles as is the case in many body-fluid derived samples.
摘要翻译： 用于检测异常蛋白质和蛋白质颗粒的催化构象传感器方法。 该方法基于肽片段或探针与异常蛋白质颗粒的相互作用。 相互作用催化探针转化为主要的β片段构象，并允许探针结合异常的蛋白质颗粒。 这反过来，催化与测试样品结合探针相关联的信号的传播。 结果，即使从含有非常低浓度的异常蛋白质颗粒的样品中也可以传播信号，就像许多体液衍生的样品一样。
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公开(公告)号：US20060275910A1
公开(公告)日：2006-12-07
申请号：US11504692
申请日：2006-08-16
申请人： Cindy Orser , Anne Grosset , Eugene Davidson
发明人： Cindy Orser , Anne Grosset , Eugene Davidson
IPC分类号： G01N33/00
CPC分类号： G01N33/542 , G01N33/6896 , G01N2800/2828
摘要： A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles as is the case in many body-fluid derived samples.
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