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1.发明授权Method for identifying combinations of motifs that do not mutate simultaneously in a set of viral polypeptide sequences comprising a putative drug binding site 有权用于鉴定在一组病毒多肽序列中同时突变的基序组合的方法，所述病毒多肽序列包含推定的药物结合位点公开(公告)号：US07917303B2
公开(公告)日：2011-03-29
申请号：US11480014
申请日：2006-06-30
申请人： Anne Vanet , Michaela Muller-Trutwin , Thomas Valère , Sophie Brouillet , Emmanuelle Ollivier , Laurent Marsan
发明人： Anne Vanet , Michaela Muller-Trutwin , Thomas Valère , Sophie Brouillet , Emmanuelle Ollivier , Laurent Marsan
IPC分类号： G01N33/48
摘要： Methods for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step (a), c) identifying motifs not having mutated simultaneously and/or motifs having mutated simultaneously at least once on at least one sequence of the set and not having mutated on another sequence of the set.
摘要翻译： 用于鉴定在一组序列中具有预定突变的布尔状态的基序或基序组合的方法，包括a）对齐由单个字符代码表示的有序基序的一组序列，b）将参考序列与所述集合进行比较 的步骤（a）中对齐的序列，c）识别不具有同时突变的基序和/或已经在该组的至少一个序列上同时突变至少一次并且在该组的另一个序列上没有突变的基序。
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2.发明授权Method for identifying motifs and/or combinations of motifs having a boolean state of predetermined mutation in a set of sequences and its application 有权用于鉴定在一组序列中具有预定突变的布尔状态的基序和/或组合的方法及其应用公开(公告)号：US08032309B2
公开(公告)日：2011-10-04
申请号：US12708194
申请日：2010-02-18
IPC分类号： G01N33/48
摘要： A method for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step (a), c) identifying motifs not having mutated simultaneously or motifs having mutated simultaneously at least once on at least one sequence of the set and not having mutated on another sequence of the set.
摘要翻译： 一种用于识别在一组序列中具有布尔状态的预定突变的基序或基序组合的方法，包括a）对齐由单个字符代码表示的有序基序的一组序列，b）将参考序列与 在步骤（a）中对齐的序列集合，c）识别未同时突变的基序或已经在该组的至少一个序列上同时突变至少一次并且在该组的另一个序列上没有突变的基序。
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3.发明申请METHOD FOR IDENTIFYING MOTIFS AND/OR COMBINATIONS OF MOTIFS HAVING A BOOLEAN STATE OF PREDETERMINED MUTATION IN A SET OF SEQUENCES AND ITS APPLICATION 有权用于识别具有一系列序列中的预测突变的布尔状态的运动和/或组合的方法及其应用公开(公告)号：US20100183670A1
公开(公告)日：2010-07-22
申请号：US12708194
申请日：2010-02-18
IPC分类号： A61K39/21 , A61K39/145 , A61K39/29 , C07K14/005 , C07H21/04 , A61P31/18 , A61P31/14 , A61P31/16 , G06F19/00
摘要： A method for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step (a), c) identifying motifs not having mutated simultaneously or motifs having mutated simultaneously at least once on at least one sequence of the set and not having mutated on another sequence of the set.
摘要翻译： 一种用于识别在一组序列中具有布尔状态的预定突变的基序或基序组合的方法，包括a）对齐由单个字符代码表示的有序基序的一组序列，b）将参考序列与 在步骤（a）中对齐的序列集合，c）识别未同时突变的基序或已经在该组的至少一个序列上同时突变至少一次并且在该组的另一个序列上没有突变的基序。
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4.发明授权Method for identifying motifs and/or combinations of motifs having a boolean state of predetermined mutation in a set of sequences and its applications 有权用于鉴定在一组序列及其应用中具有预定突变的布尔状态的基序和/或组合的方法公开(公告)号：US07734421B2
公开(公告)日：2010-06-08
申请号：US10734023
申请日：2003-12-11
IPC分类号： G01N33/48
摘要： A method for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step (a), c) identifying motifs not having mutated simultaneously or motifs having mutated simultaneously at least once on at least one sequence of the set and not having mutated on another sequence of the set.
摘要翻译： 一种用于识别在一组序列中具有布尔状态的预定突变的基序或基序组合的方法，包括a）对齐由单个字符代码表示的有序基序的一组序列，b）将参考序列与 在步骤（a）中对齐的序列集合，c）识别未同时突变的基序或已经在该组的至少一个序列上同时突变至少一次并且在该组的另一个序列上没有突变的基序。
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5.发明申请Method for identifying motifs and/or combinations of motifs having a boolean state of predetermined mutation in a set of sequences and its applications 有权用于鉴定在一组序列及其应用中具有预定突变的布尔状态的基序和/或组合的方法公开(公告)号：US20070020619A1
公开(公告)日：2007-01-25
申请号：US11480014
申请日：2006-06-30
申请人： Anne Vanet , Michaela Muller-Trutwin , Thomas Valere , Sophie Brouillet , Emmanuelle Ollivier , Laurent Marsan
发明人： Anne Vanet , Michaela Muller-Trutwin , Thomas Valere , Sophie Brouillet , Emmanuelle Ollivier , Laurent Marsan
摘要： Methods for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step (a), c) identifying motifs not having mutated simultaneously and/or motifs having mutated simultaneously at least once on at least one sequence of the set and not having mutated on another sequence of the set.
摘要翻译： 用于鉴定在一组序列中具有预定突变的布尔状态的基序或基序组合的方法，包括a）对齐由单个字符代码表示的有序基序的一组序列，b）将参考序列与所述集合进行比较 的步骤（a）中对齐的序列，c）识别不具有同时突变的基序和/或已经在该组的至少一个序列上同时突变至少一次并且在该组的另一个序列上没有突变的基序。
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