摘要:
The present invention relates to novel 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.
摘要:
One or more virtual processors can be added or removed from a virtual machine based on CPU pressure measured within the virtual machine. In addition to the foregoing, CPU pressure can also be used to determine whether to remove a virtual processor from a virtual machine, which may cause the computer system to consume less power. In the alternative, virtual processors can be parked and/or unparked in order to reduce the amount of power consumed by the virtual machine. In addition, virtual processors can be forcibly parked during a migration operation.
摘要:
Techniques for reducing virtual machine input/output emulation overhead and decreasing the attack surface of a virtual machine architecture are disclosed.
摘要:
A catch-up mode that runs a virtual programmable interrupt timer faster than a nominal rate to prevent time loss in a virtual machine can be implemented. If time loss is determined, a catch-up mode can be initiated to cause increased firings, beyond a nominal rate, of the programmable interrupt timer to adjust the clock of the virtual machine to the clock of the host system. The virtual programmable interrupt timer can also be readjusted to a predetermined nominal rate when the time loss in the guest operating system is determined approximately within a predetermined tolerance range. The catch-up mode can be monitored to avoid “interrupt storms” on the virtual machine. The virtual programmable interrupt timer can be altered by the guest operating system to accommodate different operating systems.
摘要:
Several embodiments of the present invention provide a means for improving data access security in computer systems to support high-security applications, and certain of these embodiments are specifically directed to providing sector-level encryption of a virtual hard disk in a virtual machine environment. More specifically, certain embodiments are directed to providing sector-level encryption by using plug-ins in a virtual machine environment, thereby providing improved data access security in a computer system that supports high-security applications. Certain embodiments also use encryption plug-ins associated with standard encryption software for exchanging data between a virtual machine (VM) and its associated virtual hard drive(s) (VHDs). Moreover, several embodiments of the present invention are directed to the use of plug-in encryption services that interface with, and provide services for, a VM via a VM Encryption API (or its equivalent).
摘要:
Various operations are provided that improve the scalability of virtual TLBs in multi-processor virtual machines, and they include: implicitly locking SPTs using per-processor generation counters; waiting for pending fills on other virtual processors to complete before servicing a GVA invalidation using the counters; write-protecting or unmaping guest pages in a deferred two-stage process or reclaiming SPTs in a deferred two-stage process; periodically coalescing two SPTs that shadow the same GPT with the same attributes; sharing SPTs between two SASes only at a specified level in a SPTT; flushing the entire virtual TLB using a generation counter; allocating a SPT to GPT from a NUMA node on which the GPT resides; having an instance for each NUMA node on which a virtual machine runs; and, correctly handling the serializing instructions executed by a guest in a virtual machine with more than one virtual processor sharing the virtual TLB.
摘要:
The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1, having selective α2C-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are usefull for the prevention and/or treatment of central nervous system disorders, mood disorders, anxiety disorders, stress-related disorders associated with depression and/or anxiety, cognitive disorders, personality disorders, schizoaffective disorders, Parkinson's disease, dementia of the Alzheimer's type, chronic pain conditions, neurodegenerative diseases, addiction disorders, mood disorders and sexual dysfunction.
摘要:
The present invention concerns substituted pyrazinone derivatives according to the general Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1, having selective α2C-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of central nervous system disorders, mood disorders, anxiety disorders, stress-related disorders associated with depression and/or anxiety, cognitive disorders, personality disorders, schizoaffective disorders, Parkinson's disease, dementia of the Alzheimer's type, chronic pain conditions, neurodegenerative diseases, addiction disorders, mood disorders and sexual dysfunction.
摘要:
A method of virtualizing memory through shadow page tables that cache translations from multiple guest address spaces in a virtual machine includes a software version of a hardware tagged translation look-aside buffer. Edits to guest page tables are detected by intercepting the creation of guest-writable mappings to guest page tables with translations cached in shadow page tables. The affected cached translations are marked as stale and purged upon an address space switch or an indiscriminate flush of translations by the guest. Thereby, non-stale translations remain cached but stale translations are discarded. The method includes tracking the guest-writable mappings to guest page tables, deferring discovery of such mappings to a guest page table for the first time until a purge of all cached translations when the number of untracked guest page tables exceeds a threshold, and sharing shadow page tables between shadow address spaces and between virtual processors.
摘要:
The present invention provides a virtualized computing systems and methods for transitioning in real time between LONG SUPER-MODE and LEGACY SUPER-MODE in the x86-64 architecture. In doing so, a virtual machine, which relies on the traditional 32-bit modes, i.e., REAL MODE and PROTECTED MODE (V86 SUB-MODE, RING-0 SUB-MODE, and RING-3 SUB-MODE), is able to run alongside other applications on x86-64 computer hardware (i.e., 64-bit). The method of performing a temporary processor mode context switch includes the steps of the virtual machine monitor's setting up a “virtual=real” page, placing the transition code for performing the processor mode context switch on this page, jumping to this page, disabling the memory management unit (MMU) of the x86-64 computer hardware, modifying the mode control register to set either the LONG SUPER-MODE bit or LEGACY SUPER-MODE bit, loading a new page table, and reactivating the MMU of the x86-64 computer hardware.