公开(公告)号：US20140194462A1

公开(公告)日：2014-07-10

申请号：US14048957

申请日：2013-10-08

申请人： Anvyl LLC

发明人： Richard Kanner

IPC分类号： C07D495/04 ,  C07D491/052

CPC分类号： C07D495/04 ,  C07D471/04 ,  C07D491/052

摘要： The present application is related to compounds represented by Formula I, which are novel allosteric modulators of α7nAChR. The application also discloses the treatment of disorders that are responsive to modulation of acetylcholine action on α7nAChR in a mammal by administering an effective amount of a compound of Formula I.

摘要翻译： 本申请涉及由式I表示的化合物，其是α7nAChR的新型变构调节剂。 该申请还公开了通过施用有效量的式I化合物来治疗对哺乳动物中对α7nAChR的乙酰胆碱作用的调节作用的病症的治疗。

公开(公告)号：US10736901B2

公开(公告)日：2020-08-11

申请号：US16138509

申请日：2018-09-21

申请人： Anvyl, LLC

发明人： Olivier Dasse

IPC分类号： A61K31/536 ,  A61K31/395 ,  A61K31/535 ,  A61P25/00 ,  A61K31/015 ,  A61K31/03 ,  C07B59/00 ,  C07D265/18

摘要： This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to methods for their preparation and use, and to pharmaceutical compositions. Briefly, this invention is generally directed to deuterated analogs of etifoxine as well as to methods for their preparation and use, and to pharmaceutical compositions containing the same.

公开(公告)号：US10080755B2

公开(公告)日：2018-09-25

申请号：US15557748

申请日：2016-03-18

申请人： Anvyl, LLC

发明人： Olivier Dasse

IPC分类号： A61K31/536 ,  A61K31/03 ,  C07D265/18 ,  C07B59/00 ,  A61K31/015

CPC分类号： A61K31/536 ,  A61K31/015 ,  A61K31/03 ,  A61K31/395 ,  A61K31/535 ,  A61K2300/00 ,  A61P25/00 ,  C07B59/002 ,  C07D265/18

摘要： This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to methods for their preparation and use, and to pharmaceutical compositions. Briefly, this invention is generally directed to deuterated analogs of etifoxine as well as to methods for their preparation and use, and to pharmaceutical compositions containing the same.

公开(公告)号：US20190015419A1

公开(公告)日：2019-01-17

申请号：US16138509

申请日：2018-09-21

申请人： Anvyl, LLC

发明人： Olivier Dasse

IPC分类号： A61K31/536 ,  C07D265/18 ,  C07B59/00 ,  A61K31/395 ,  A61K31/015 ,  A61K31/535 ,  A61K31/03

摘要： This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to methods for their preparation and use, and to pharmaceutical compositions. Briefly, this invention is generally directed to deuterated analogs of etifoxine as well as to methods for their preparation and use, and to pharmaceutical compositions containing the same.

公开(公告)号：US20180064717A1

公开(公告)日：2018-03-08

申请号：US15557748

申请日：2016-03-18

申请人： Anvyl, LLC

发明人： Olivier Dasse

IPC分类号： A61K31/536 ,  A61K31/03 ,  A61K31/015 ,  C07D265/18 ,  C07B59/00

CPC分类号： A61K31/536 ,  A61K31/015 ,  A61K31/03 ,  A61K31/395 ,  A61K31/535 ,  A61K2300/00 ,  C07B59/002 ,  C07D265/18

摘要： This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to methods for their preparation and use, and to pharmaceutical compositions. Briefly, this invention is generally directed to deuterated analogs of etifoxine as well as to methods for their preparation and use, and to pharmaceutical compositions containing the same.

公开(公告)号：US20150099758A1

公开(公告)日：2015-04-09

申请号：US14398968

申请日：2013-05-08

申请人： Anvyl LLC

发明人： David Putnam ,  Olivier Dasse

IPC分类号： C07D213/81 ,  C07D401/14 ,  C07D261/18 ,  C07D213/82 ,  C07D237/24 ,  C07D401/06 ,  C07D403/06

CPC分类号： C07D213/81 ,  C07D213/82 ,  C07D237/24 ,  C07D261/18 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06

摘要： The present application is related to compounds represented by Formula I, which are novel positive allosteric modulators of al nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on al nAChRs in a mammal by administering an effective amount of a compound of Formula I.

摘要翻译： 本申请涉及由式I表示的化合物，其是al nAChR的新型正变构调节剂。 本申请还公开了通过施用有效量的式I化合物来治疗对哺乳动物中对nACHRs的乙酰胆碱作用增强有反应作用的病症。

公开(公告)号：US08975407B2

公开(公告)日：2015-03-10

申请号：US14048957

申请日：2013-10-08

申请人： Anvyl LLC

发明人： Richard Kanner

IPC分类号： C07D215/38 ,  C07D495/04 ,  C07D471/04 ,  C07D491/052

CPC分类号： C07D495/04 ,  C07D471/04 ,  C07D491/052

摘要： The present application is related to compounds represented by Formula I, which are novel allosteric modulators of α7nAChR. The application also discloses the treatment of disorders that are responsive to modulation of acetylcholine action on α7nAChR in a mammal by administering an effective amount of a compound of Formula I

摘要翻译： 本申请涉及由式I表示的化合物，其是α7nAChR的新型变构调节剂。 本申请还公开了通过施用有效量的式I化合物来治疗对哺乳动物中对α7nAChR的乙酰胆碱作用的调节作用的病症的治疗