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1.发明授权
公开(公告)号：US5849756A
公开(公告)日：1998-12-15
申请号：US450491
申请日：1995-05-26
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4704 , A61P37/02 , A61P37/04 , A61P37/06 , C07D209/34 , C07D215/50
CPC分类号： C07D215/50 , A61K31/405 , A61K31/4704 , C07D209/34
摘要： Pharmaceutical compositions for the modulation of the immune reaction of warm blooded animals that are derivatives of the 2-oxindole-3-acetic acid or the 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid are described, and whereby the derivatives can optionally be in an equilibrium with each other. The derivatives included in the pharmaceutical compositions comprise those compounds which are already described in the literature and also new compounds. Furthermore, new derivatives of the the 2-oxindole-3-acetic acid and the 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid are described, particularly also the the pure antipodes of the mixture of enantiomeres of the 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid.
摘要翻译： 描述了作为2-羟基吲哚-3-乙酸或2-氧代-1,2,3,4-四氢喹啉-4-羧酸的衍生物的温血动物的免疫反应调节用药物组合物，以及 由此衍生物可以任选地彼此平衡。 包含在药物组合物中的衍生物包括已经在文献中描述的那些化合物，也是新的化合物。 此外，还描述了2-羟基吲哚-3-乙酸和2-氧代-1,2,3,4-四氢喹啉-4-羧酸的新衍生物，特别是对映异构体的对映体混合物的纯对映体 2-氧代-1,2,3,4-四氢喹啉-4-羧酸。
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公开(公告)号：US4952399A
公开(公告)日：1990-08-28
申请号：US384054
申请日：1989-07-20
申请人： Ari Lewenstein , Fouad K. Habib
发明人： Ari Lewenstein , Fouad K. Habib
IPC分类号： A61K20060101 , A61K36/00 , A61K39/36
CPC分类号： A61K36/00
摘要： Extracts which were recovered with aqueous extraction media from the pollen of plants inhibit the growth of tumor-cells and stimulate at the same time the metabolism of normal healthy cells. Said extracts of pollen which do not contain more than 5% by weight of proteins having a high molecular weight or which are completely free of such proteins of high molecular weight, are used as active ingredient of corresponding pharmaceutical preparations and they are used for treating cancer, tumors and leukemia in human beings or warm blooded animals. Living leukemia cells are rapidly killed by said extracts. The pollen extracts in question are a yellowish-white product and they usually contain, referred to the dry weight of the pollen extracts, at least 70% by weight of carbohydrates, 5-12% by weight of amino acids, peptides and/or proteinous substances and furthermore water soluble vitamines of the group B and mineral constituents.From said yellowish-white pollen extracts a new fraction was isolated which is, compared with the pollen extracts, enriched in amino acids and/or peptides and/or proteinous substances.
摘要翻译： 从植物花粉中萃取水溶液回收的提取物抑制肿瘤细胞的生长，同时刺激正常健康细胞的代谢。 使用不含超过5重量％的具有高分子量蛋白质或完全不含高分子量蛋白质的花粉的所述提取物作为相应药物制剂的活性成分，并用于治疗癌症 ，人类的肿瘤和白血病或温血动物。 活体白血病细胞被所述提取物快速杀死。 所讨论的花粉提取物是黄白色产品，它们通常含有以花粉提取物的干重计，至少70重量％的碳水化合物，5-12重量％的氨基酸，肽和/或蛋白质 B物质和矿物成分的水溶性维生素。 从所述黄白色花粉提取物中分离出与富含氨基酸和/或肽和/或蛋白质物质的花粉提取物相比的新级分。
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3.发明授权Glycosides isolated from pollen, their sugar-free decomposition products and derivatives thereof 失效从花粉中分离的糖苷，其无糖分解产物及其衍生物
公开(公告)号：US5712377A
公开(公告)日：1998-01-27
申请号：US672651
申请日：1996-06-28
IPC分类号： C07H15/18 , A61K31/70 , A61K31/7028 , A61K36/00 , A61P31/12 , A61P31/18 , A61P35/00 , C07C62/32 , C07C62/34 , C07C69/757 , C07H15/26 , C07H17/08 , C07C315/00
CPC分类号： C07H17/08 , C07C62/32 , C07C62/34 , C07C69/757
摘要： What are described are new glucosides and their sugar-free decomposition products, as well as synthetically produced derivatives, which can be used as active components of pharmaceutical compositions. The novel glucosides have been isolated from aqueous extracts of vegetable pollen. These novel glucosides, sugar-free decomposition products and their derivatives have the effectiveness to modulate the immune system of warm blooded animals and they can be used as active components in pharmaceutical compositions for the treatment of tumors and virus-related diseases.
摘要翻译： 所描述的是新的葡糖苷及其无糖分解产物，以及可用作药物组合物的活性组分的合成产生的衍生物。 新型葡萄糖苷已经从植物花粉的水提取物中分离出来。 这些新型糖苷，无糖分解产物及其衍生物具有调节温血动物免疫系统的有效性，可用作药物组合物中用于治疗肿瘤和病毒相关疾病的活性成分。
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4.发明授权
公开(公告)号：US4774226A
公开(公告)日：1988-09-27
申请号：US860127
申请日：1986-05-06
申请人： Ari Lewenstein
发明人： Ari Lewenstein
CPC分类号： A61K39/36 , Y10S514/826
摘要： A pharmaceutical preparation for the prophylactic treatment of allergies which contains as active ingredient an extract of pollen which contains nor more than 5% by weight, referred to the dry weight of the extract of pollen, of proteins having a high molecular weight or which is completely free of proteins of high molecular weight. The active ingredients of the inventive pharmaceutical preparation have themselves no allergen activity. To those human beings and children which in the years before suffered from severe symptoms of hay fever or asthma, the inventive pharmaceutical preparations were administered, preferably orally, during about three months before the allergy usually had occurred, for instance in the months February until April. By said administration the occurring of the pollen allergy in spring time and during the whole summer could be completely prevented. The inventive pharmaceutical preparations are prepared by extracting the pollen of plants with an aqueous extraction medium, and by metabolizing high molecular proteins of the pollen with a microorganism yielding low molecular proteins or amino acids. Thereafter the aqueous extraction medium is separated from the pollen and the pollen are extracted further with a not aqueous extraction medium. The concentrated extract or the dry residue of the extract recovered with the aqueous medium or the not aqueous medium or a mixture of the extracts or dry residues recovered with the aqueous medium and the not aqueous medium are the active ingredient of the inventive pharmaceutical preparations.
摘要翻译： 一种用于预防性治疗过敏症的药物制剂，其包含作为活性成分的花粉提取物，其含量不超过5重量％，称为花粉提取物的干重，具有高分子量的蛋白质或完全 不含高分子量的蛋白质。 本发明药物制剂的活性成分本身没有过敏原活性。 对于那些在遭受过花粉症或哮喘严重症状的岁月中的人类和儿童，本发明的药物制剂在通常发生过敏之前约3个月内，优选口服给药，例如在2月至4月期间 。 通过管理，可以完全防止春季和整个夏季花粉过敏的发生。 本发明的药物制剂通过用含水提取介质提取植物花粉，并用产生低分子蛋白质或氨基酸的微生物代谢花粉的高分子蛋白质来制备。 此后，从花粉中分离含水萃取介质，并用非水萃取介质进一步提取花粉。 用水性介质或非水性介质回收的提取物的浓缩提取物或干燥残余物或用水性介质和非水性介质回收的提取物或干燥残余物的混合物是本发明的药物制剂的活性成分。
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