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    Use of chimeric vaccinia virus complement control proteins to inhibit complement
    1.
    发明授权
    Use of chimeric vaccinia virus complement control proteins to inhibit complement 失效
    使用嵌合痘苗病毒补体对照蛋白抑制补体

    公开(公告)号：US5843778A

    公开(公告)日：1998-12-01

    申请号：US874978

    申请日：1997-06-13

    申请人： Ariella M. Rosengard ,  Joseph M. Ahearn, Jr. ,  Alfred P. Sanfilippo ,  William M. Baldwin, III

    发明人： Ariella M. Rosengard ,  Joseph M. Ahearn, Jr. ,  Alfred P. Sanfilippo ,  William M. Baldwin, III

    IPC分类号： A61K35/14 ,  A61K38/00 ,  C07K14/07 ,  C07K14/705 ,  C12N15/39 ,  C12P21/00 ,  C07H21/04 ,  C12N5/10

    CPC分类号： C07K14/005 ,  C07K14/70596 ,  A01K2217/05 ,  A61K38/00 ,  C07K2319/00 ,  C12N2710/24122

    摘要： Disclosed are chimeric proteins that are useful for inhibiting complement. The chimeric protein termed VCPFc is a fusion protein in which (i) an immunoglobulin Fc region is fused to (ii) a polypeptide that comprises a portion of a vaccinia virus complement control protein which binds complement components C4b and C3b, but not iC3b rosettes. This protein can be use in xenograft transplantation methods (e.g., by treating the donor mammal or organ) and in methods for treating complement-mediated disorders (e.g., inflammation) generally. In a second chimeric protein, a transmembrane anchoring domain is fused to a polypeptide that comprises a portion of a vaccinia virus complement control protein which binds complement components C4b and C3b, but not iC3b rosettes. The transmembrane anchoring domain can be, for example, short consensus regions 3 through 15 of human complement receptor 2 protein. Expression of the transmembrane-anchored fusion protein in a transgenic animal provides a well-suited organ donor for xenograft transplantation.

    摘要翻译： 公开了可用于抑制补体的嵌合蛋白。 称为VCPFc的嵌合蛋白是融合蛋白，其中（i）免疫球蛋白Fc区融合到（ii）包含部分痘苗病毒补体对照蛋白的多肽，其结合补体成分C4b和C3b，但不结合iC3b花环。 该蛋白质可以用于异种移植物移植方法（例如，通过治疗供体哺乳动物或器官）和通常用于治疗补体介导的病症（例如炎症）的方法中。 在第二嵌合蛋白中，跨膜锚定结构域融合到包含部分痘苗病毒补体对照蛋白的多肽，所述痘苗病毒补体对照蛋白结合补体成分C4b和C3b，但不结合iC3b玫瑰花结。 跨膜锚定结构域可以是例如人补体受体2蛋白的短共有区域3至15。 跨膜锚定的融合蛋白在转基因动物中的表达提供了用于异种移植物移植的非常适合的器官供体。

    Use of chimeric vaccinia virus complement control proteins to inhibit complement
    3.
    发明授权
    Use of chimeric vaccinia virus complement control proteins to inhibit complement 失效
    使用嵌合痘苗病毒补体对照蛋白抑制补体

    公开(公告)号：US6140472A

    公开(公告)日：2000-10-31

    申请号：US201075

    申请日：1998-11-30

    申请人： Ariella M. Rosengard ,  Joseph M. Ahearn, Jr. ,  Alfred P. Sanfilippo ,  William M. Baldwin, III

    发明人： Ariella M. Rosengard ,  Joseph M. Ahearn, Jr. ,  Alfred P. Sanfilippo ,  William M. Baldwin, III

    IPC分类号： A61K35/14 ,  A61K38/00 ,  C07K14/07 ,  C07K14/705 ,  C12N15/39 ,  C07K16/46

    CPC分类号： C07K14/005 ,  C07K14/70596 ,  A01K2217/05 ,  A61K38/00 ,  C07K2319/00 ,  C12N2710/24122

    摘要： Disclosed are chimeric proteins that are useful for inhibiting complement. The chimeric protein termed VCPFc is a fusion protein in which (i) an immunoglobulin Fc region is fused to (ii) a polypeptide that comprises a portion of a vaccinia virus complement control protein which binds complement components C4b and C3b, but not iC3b rosettes. This protein can be used in xenograft transplantation methods (e.g., by treating the donor mammal or organ) and in methods for treating complement-mediated disorders (e.g., inflammation) generally. In a second chimeric protein, a transmembrane anchoring domain is fused to a polypeptide that comprises a portion of a vaccinia virus complement control protein which binds complement components C4b and C3b, but not iC3b rosettes. The transmembrane anchoring domain can be, for example, short consensus regions 3 through 15 of human complement receptor 2 protein. Expression of the transmembrane-anchored fusion protein in a transgenic animal provides a well-suited organ donor for xenograft transplantation.

    摘要翻译： 公开了可用于抑制补体的嵌合蛋白。 称为VCPFc的嵌合蛋白是融合蛋白，其中（i）免疫球蛋白Fc区融合到（ii）包含部分痘苗病毒补体对照蛋白的多肽，其结合补体成分C4b和C3b，但不结合iC3b花环。 该蛋白质可以用于异种移植物移植方法（例如通过治疗供体哺乳动物或器官）和通常用于治疗补体介导的病症（例如炎症）的方法。 在第二嵌合蛋白中，跨膜锚定结构域融合到包含部分痘苗病毒补体对照蛋白的多肽，所述痘苗病毒补体对照蛋白结合补体成分C4b和C3b，但不结合iC3b玫瑰花结。 跨膜锚定结构域可以是例如人补体受体2蛋白的短共有区域3至15。 跨膜锚定的融合蛋白在转基因动物中的表达提供了用于异种移植物移植的非常适合的器官供体。