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公开(公告)号:US20170049748A1
公开(公告)日:2017-02-23
申请号:US15237435
申请日:2016-08-15
IPC分类号: A61K31/415 , A61K47/10 , A61K9/00 , A61K47/18
CPC分类号: A61K31/415 , A61K9/0014 , A61K31/164 , A61K47/10 , A61K47/18 , A61K2300/00
摘要: Methods and compositions for enhancing transungual delivery of AR-12 comprising administering AR-12 and permeation enhancers are provided.
摘要翻译: 提供了用于增强AR-12的跨越递送的方法和组合物,其包括给予AR-12和渗透促进剂。
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公开(公告)号:US20170266204A1
公开(公告)日:2017-09-21
申请号:US15464085
申请日:2017-03-20
发明人: Stefan Proniuk , Souzan Yanni
IPC分类号: A61K31/575 , A61K45/06
CPC分类号: A61K31/575 , A61K31/337 , A61K31/436 , A61K31/513 , A61K31/555 , A61K31/58 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要: Methods and pharmaceutical compositions for inhibiting the activity of the progesterone receptor with methyl onapristone. Aspects include methods of administering methyl onapristone to a patient in an amount sufficient to achieve a blood or tissue concentration of at least about 100 nM.
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公开(公告)号:US20170088579A1
公开(公告)日:2017-03-30
申请号:US15274555
申请日:2016-09-23
IPC分类号: C07J33/00
CPC分类号: C07J33/005 , C07J41/0083
摘要: Methods and systems for making intermediates in the synthesis of onapristone are provided. Aspects include the photoconversion of onapristone synthesis intermediates using a narrow band frequency light source.
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公开(公告)号:US20160199351A1
公开(公告)日:2016-07-14
申请号:US14990594
申请日:2016-01-07
IPC分类号: A61K31/415 , A61K45/06
CPC分类号: A61K31/415 , A61K31/4196 , A61K45/06 , A61P31/10 , A61K2300/00
摘要: Compositions and methods for inhibiting fungal growth by administering AR-12 to a host infected with a fungus such as Histoplasma capsulatum, Aspergillus fumigatus, and Trichophyton rubrum, Paecilomyces, Rhizopus, Fusarium, Scedosporium, Lomentospora, Apophysomyces, Coccidioides, Blastomyces, non-albicans Candida, and Pneumocytis are provided.
摘要翻译: 通过向感染了真菌如宿主感染的宿主(例如烟曲霉,烟曲霉,红假丝酵母,拟青霉,根霉,镰刀菌,孢子孢子,野生芽孢杆菌,Apophysomyces,Coccidioides,Blastomyces,非白色念珠菌等)施用AR-12的组合物和方法 念珠菌和肺动脉炎。
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公开(公告)号:US20210221838A1
公开(公告)日:2021-07-22
申请号:US17034598
申请日:2020-09-28
发明人: Ulf Tilstam , Stefan Proniuk , Ferry Brands
摘要: Methods and systems for making onapristone (ONA) using acidic hydrolysis and dehydration with sulfuric acid in an alcoholic solution are provided.
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公开(公告)号:US20180148471A1
公开(公告)日:2018-05-31
申请号:US15825697
申请日:2017-11-29
发明人: Ulf Tilstam , Stefan Proniuk , Ferry Brands
CPC分类号: C07J41/0083 , C07J21/006
摘要: Methods and systems for making onapristone (ONA) using acidic hydrolysis and dehydration with sulfuric acid in an alcoholic solution are provided.
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公开(公告)号:US09579387B2
公开(公告)日:2017-02-28
申请号:US14854527
申请日:2015-09-15
IPC分类号: A61K9/20 , A61K47/34 , A61K31/415 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38
CPC分类号: A61K47/34 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/415 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38
摘要: A drug delivery system is presented to increase the bioavailability of biopharmaceutic class II, III, or IV active agents.
摘要翻译: 提出了一种药物递送系统,以提高生物制药二级,三级或四级活性剂的生物利用度。
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公开(公告)号:US09744156B2
公开(公告)日:2017-08-29
申请号:US15237435
申请日:2016-08-15
IPC分类号: A61K31/415 , A61K47/18 , A61K47/10 , A61K9/00
CPC分类号: A61K31/415 , A61K9/0014 , A61K31/164 , A61K47/10 , A61K47/18 , A61K2300/00
摘要: Methods and compositions for enhancing transungual delivery of AR-12 comprising administering AR-12 and permeation enhancers are provided.
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公开(公告)号:US20160213647A1
公开(公告)日:2016-07-28
申请号:US15008306
申请日:2016-01-27
发明人: Larry Schlesinger , Jacob Yount , Alexander Zukiwski , Stefan Proniuk , María Jesús Tuñón , Keivan Zandi
IPC分类号: A61K31/415 , A61K45/06
CPC分类号: A61K31/415 , A61K45/06 , Y02A50/382 , Y02A50/385 , Y02A50/387 , Y02A50/393
摘要: Compositions and methods for inhibiting viral protein production, viral infection, and viral replication in a host or host cells infected with a virus (e.g., influenza, Junin, Chikungunya, Dengue, HIV, RHDV) by administering AR-12 and AR-12 analogs are provided.
摘要翻译: 通过施用AR-12和AR-12类似物,在感染病毒的宿主或宿主细胞(例如流感,Junin,基孔肯雅,登革热,HIV,RHDV)中抑制病毒蛋白质产生,病毒感染和病毒复制的组合物和方法 被提供。
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公开(公告)号:US20180000945A1
公开(公告)日:2018-01-04
申请号:US15416745
申请日:2017-01-26
IPC分类号: A61K47/34 , A61K47/32 , A61K31/415 , A61K47/14 , A61K47/02 , A61K9/20 , A61K47/38 , A61K47/26
CPC分类号: A61K47/34 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/415 , A61K47/02 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38
摘要: A drug delivery system is presented to increase the bioavailability of biopharmaceutic class II, III, or IV active agents.
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