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    Human suppressor of fused
    2.
    发明申请
    Human suppressor of fused 有权
    融合人的抑制子

    公开(公告)号：US20050196814A1

    公开(公告)日：2005-09-08

    申请号：US11096396

    申请日：2005-04-01

    申请人： Frederic de Sauvage ,  Maximilien Murone ,  Arnon Rosenthal ,  Donna Stone ,  Austin Gurney ,  William Wood

    发明人： Frederic de Sauvage ,  Maximilien Murone ,  Arnon Rosenthal ,  Donna Stone ,  Austin Gurney ,  William Wood

    IPC分类号： C07K14/47 ,  G01N33/53 ,  C12Q1/66

    CPC分类号： C07K14/4703 ,  C07K2319/00

    摘要： The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 本发明涉及与黑腹果蝇融合蛋白的多肽抑制子和编码那些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

    Bicyclic compounds and their uses as dual c-SRC / JAK inhibitors
    8.
    发明授权
    Bicyclic compounds and their uses as dual c-SRC / JAK inhibitors 失效
    双环化合物及其作为双重c-SRC / JAK抑制剂的用途

    公开(公告)号：US08440679B2

    公开(公告)日：2013-05-14

    申请号：US13578656

    申请日：2011-02-17

    申请人： Andrès Mc Allister ,  Maximilien Murone ,  Saumitra Sengupta ,  Shankar Jayaram Shetty

    发明人： Andrès Mc Allister ,  Maximilien Murone ,  Saumitra Sengupta ,  Shankar Jayaram Shetty

    IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00

    CPC分类号： C07D471/04

    摘要： The present invention relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the STAT3 activation and therefore abnormal growth of particular cell types. Notably, the compounds of the present invention are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.

    摘要翻译： 本发明涉及含有具有结构的式（I）的嘧啶和吡啶环的取代的芳族二环化合物及其药学上可接受的盐。 本发明的化合物可用作酪氨酸激酶抑制剂，优选SRC家族激酶（SFK）抑制剂，特别是多SFK / JAK。 激酶抑制剂，甚至优选作为双重c-SRC / JAK激酶抑制剂，从而抑制STAT3活化，因此抑制特定细胞类型的异常生长。 值得注意的是，本发明的化合物可用于治疗或抑制由STAT3失调引起的某些疾病。

    Bicyclic compounds and their uses as dual c-SRC/JAK inhibitors
    9.
    发明授权
    Bicyclic compounds and their uses as dual c-SRC/JAK inhibitors 有权
    双环化合物及其作为双重c-SRC / JAK抑制剂的用途

    公开(公告)号：US08962637B2

    公开(公告)日：2015-02-24

    申请号：US13741019

    申请日：2013-01-14

    申请人： Andrès Mc Allister ,  Maximilien Murone ,  Saumitra Sengupta ,  Shankar Jayaram Shetty

    发明人： Andrès Mc Allister ,  Maximilien Murone ,  Saumitra Sengupta ,  Shankar Jayaram Shetty

    IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00

    CPC分类号： C07D471/04

    摘要： The present invention relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the STAT3 activation and therefore abnormal growth of particular cell types. Notably, the compounds of the present invention are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.

    摘要翻译： 本发明涉及含有具有结构的式（I）的嘧啶和吡啶环的取代的芳族二环化合物及其药学上可接受的盐。 本发明的化合物可用作酪氨酸激酶抑制剂，优选SRC家族激酶（SFK）抑制剂，特别是多SFK / JAK。 激酶抑制剂，甚至优选作为双重c-SRC / JAK激酶抑制剂，从而抑制STAT3活化，因此抑制特定细胞类型的异常生长。 值得注意的是，本发明的化合物可用于治疗或抑制由STAT3失调引起的某些疾病。

    BICYCLIC COMPOUNDS AND THEIR USES AS DUAL C-SRC / JAK INHIBITORS
    10.
    发明申请
    BICYCLIC COMPOUNDS AND THEIR USES AS DUAL C-SRC / JAK INHIBITORS 有权
    双相化合物及其作为双C-SRC / JAK抑制剂的用途

    公开(公告)号：US20130143895A1

    公开(公告)日：2013-06-06

    申请号：US13741019

    申请日：2013-01-14

    申请人： Andrès Mc Allister ,  Maximilien Murone ,  Saumitra Sengupta ,  Shankar Jayaram Shetty

    发明人： Andrès Mc Allister ,  Maximilien Murone ,  Saumitra Sengupta ,  Shankar Jayaram Shetty

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： The present invention relates to substituted aromatic bicyclic compounds containing pyrimidine and pyridine rings of formula (I) having the structure as well as pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as tyrosine kinase inhibitors, preferably SRC family kinases (SFKs) inhibitors, in particular as multi SFK/JAK. kinases inhibitors and even preferably as dual c-SRC/JAK kinases inhibitors, thereby inhibiting the STAT3 activation and therefore abnormal growth of particular cell types. Notably, the compounds of the present invention are useful for the treatment or inhibition of certain diseases that are the result of deregulation of STAT3.

    摘要翻译： 本发明涉及含有具有结构的式（I）的嘧啶和吡啶环的取代的芳族二环化合物及其药学上可接受的盐。 本发明的化合物可用作酪氨酸激酶抑制剂，优选SRC家族激酶（SFK）抑制剂，特别是多SFK / JAK。 激酶抑制剂，甚至优选作为双重c-SRC / JAK激酶抑制剂，从而抑制STAT3活化，因此抑制特定细胞类型的异常生长。 值得注意的是，本发明的化合物可用于治疗或抑制由STAT3失调引起的某些疾病。