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1.发明授权Phaleria macrocarpa extract, extraction process and its use as cholesteryl ester transferase protein (CETP) inhibitor 有权Phaleria macrocarpa提取物，提取过程及其用作胆固醇酯转移酶蛋白（CETP）抑制剂公开(公告)号：US08999404B2
公开(公告)日：2015-04-07
申请号：US14111939
申请日：2012-04-19
IPC分类号： A01N65/00 , A61K36/83 , A61K31/201 , A61K31/202 , A61K45/06
CPC分类号： A61K36/83 , A61K31/201 , A61K31/202 , A61K45/06 , A61K2236/333
摘要： An extract and/or herbal fraction and pharmaceutical preparation include extract of Phaleria macrocarpa which for the purpose of this invention, is referred to as DLBS1449. The herbal extract according to the teaching of this invention is effectively applicable to inhibit the expression and activity of Cholesteryl Ester Transferase Protein (CETP), increase HDL cholesterol level, decrease LDL cholesterol level without raising blood pressure therefore it is further applicable in atherosclerosis therapy.
摘要翻译： 提取物和/或草药部分和药物制剂包括对本发明目的的大戟属提取物称为DLBS1449。 根据本发明教导的草药提取物可有效地用于抑制胆固醇酯转移酶蛋白（CETP）的表达和活性，提高HDL胆固醇水平，降低LDL胆固醇水平而不升高血压，因此可进一步适用于动脉粥样硬化治疗。
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2.发明申请ISOLATED COMPOUNDS FROM PHALERIA MACROCARPA AS ANTI-CANCER AGENTS 有权来自PHALERIA MACROCARPA的分离化合物作为抗癌剂公开(公告)号：US20110257112A1
公开(公告)日：2011-10-20
申请号：US13131261
申请日：2009-11-26
IPC分类号： A61K31/7034 , A61P15/00 , A61P35/00 , C07C49/255 , C07H15/203
CPC分类号： C07H15/203 , A61K36/83 , C07C49/84
摘要： The invention concerns compounds DLBS1425E2.2 and DLBS1425F1 isolated and identified from the extract of the plant Phaleria macrocarpa (Scheff.) Boerl. The invention also relates to the use of said compounds, either as a single active compound or in combination, in a pharmaceutical dosage form that has anti-proliferative activity of cancer cells, and its use relating to female related diseases. Formula (I).
摘要翻译： 本发明涉及从植物Phaleria macrocarpa（Scheff。）Boerl的提取物中分离和鉴定的化合物DLBS1425E2.2和DLBS1425F1。 本发明还涉及所述化合物作为单一活性化合物或组合用于具有癌细胞的抗增殖活性的药物剂型及其与女性相关疾病有关的用途。 式（I）。
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3.发明授权Extract of Phaleria macrocarpa as an antineoplastic, anti-inflammatory and antiangiogenic agent 有权Phaleria macrocarpa的提取物作为抗肿瘤，抗炎和抗血管生成剂公开(公告)号：US09078917B2
公开(公告)日：2015-07-14
申请号：US12997171
申请日：2009-06-08
CPC分类号： A61K36/83
摘要： A pharmaceutical dosage form comprising an extract of Phaleria macrocarpa which has antineoplastic, anti-inflammatory, and antiangiogenic activity. Its use as an antineoplastic agent is to inhibit tumour growth. Its use as an anti-inflammatory agent is to relieve inflammation and pain, and also as an antipyretic. Another use is as an antiangiogenic agent to inhibit the growth of new blood vessels to prevent cancer metastasis.
摘要翻译： 一种药物剂型，其包含具有抗肿瘤，抗炎和抗血管生成活性的大戟提取物。 其用作抗肿瘤药物是抑制肿瘤生长。 其作为抗炎剂的用途是缓解炎症和疼痛，并且作为解热药。 另一个用途是作为一种抗血管生成剂来抑制新血管的生长以预防癌症转移。
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公开(公告)号：US08569382B2
公开(公告)日：2013-10-29
申请号：US13131261
申请日：2009-11-26
CPC分类号： C07H15/203 , A61K36/83 , C07C49/84
摘要： The invention concerns compounds DLBS1425E2.2 and DLBS1425F1 isolated and identified from the extract of the plant Phaleria macrocarpa (Scheff.) Boerl. The invention also relates to the use of said compounds, either as a single active compound or in combination, in a pharmaceutical dosage form that has anti-proliferative activity of cancer cells, and its use relating to female related diseases. Formula (I).
摘要翻译： 本发明涉及从植物Phaleria macrocarpa（Scheff。）Boerl的提取物中分离和鉴定的化合物DLBS1425E2.2和DLBS1425F1。 本发明还涉及所述化合物作为单一活性化合物或组合用于具有癌细胞的抗增殖活性的药物剂型及其与女性相关疾病有关的用途。 式（I）。
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5.发明申请EXTRACT OF PHALERIA MACROCARPA AS AN ANTINEOPLASTIC, ANTI-INFLAMMATORY AND ANTIANGIOGENIC AGENT 有权作为抗肿瘤药物，抗炎药和抗生素的药物的提取物公开(公告)号：US20110091395A1
公开(公告)日：2011-04-21
申请号：US12997171
申请日：2009-06-08
CPC分类号： A61K36/83
摘要： A pharmaceutical dosage form comprising an extract of Phaleria macrocarpa which has antineoplastic, anti-inflammatory, and antiangiogenic activity. Its use as an antineoplastic agent is to inhibit tumour growth. Its use as an anti-inflammatory agent is to relieve inflammation and pain, and also as an antipyretic. Another use is as an antiangiogenic agent to inhibit the growth of new blood vessels to prevent cancer metastasis.
摘要翻译： 一种药物剂型，其包含具有抗肿瘤，抗炎和抗血管生成活性的大戟提取物。 其用作抗肿瘤药物是抑制肿瘤生长。 其作为抗炎剂的用途是缓解炎症和疼痛，并且作为解热药。 另一个用途是作为一种抗血管生成剂来抑制新血管的生长以预防癌症转移。
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