公开(公告)号：US20060040916A1

公开(公告)日：2006-02-23

申请号：US11259509

申请日：2005-10-26

Applicant: Hiroyuki Chiba ,  Masahiko Tsujii ,  Astsushi Koiwa ,  Shin Sakurai ,  Akio Kayano ,  Hiroyuki Ishizuka ,  Hiroyuki Saito ,  Taiju Nakamura ,  Ikuo Kushida ,  Yasuyuki Suzuki ,  Takako Yoshiba ,  Kazuhide Ashizawa ,  Masahiro Sakurai ,  Eiichi Yamamoto

Inventor： Hiroyuki Chiba ,  Masahiko Tsujii ,  Astsushi Koiwa ,  Shin Sakurai ,  Akio Kayano ,  Hiroyuki Ishizuka ,  Hiroyuki Saito ,  Taiju Nakamura ,  Ikuo Kushida ,  Yasuyuki Suzuki ,  Takako Yoshiba ,  Kazuhide Ashizawa ,  Masahiro Sakurai ,  Eiichi Yamamoto

IPC: C07D487/04 ,  A61K31/407

CPC classification number: C07D477/20 ,  A61K31/407

Abstract: The present invention provides carbapenem hydrochloride trihydrate crystals, which are chemically stable, easily purified and useful as antimicrobial agents, a process for producing them, and a powdery charged preparation for injection containing them. That is, it provides carbapenem hydrochloride trihydrate crystals having a powdery X-ray diffraction pattern containing lattice distances (d) of 9.0, 4.1 and 2.8 Å, a process for producing them, and a powdery charged preparation for injection containing them.

Abstract translation: 本发明提供化学稳定，易于纯化和用作抗微生物剂的盐酸碳青霉烯盐酸盐三水合物晶体，其制备方法和含有它们的注射用粉末状药物制剂。 也就是说，它提供了具有包含晶格距离（d）为9.0,4.1和2.8的粉末X射线衍射图的碳青霉烯盐酸盐三水合物晶体，其制备方法和含有它们的注射用粉末状药物制剂。

公开(公告)号：US07084268B1

公开(公告)日：2006-08-01

申请号：US09979679

申请日：2000-06-05

Applicant: Hiroyuki Chiba ,  Masahiko Tsujii ,  Astsushi Koiwa ,  Shin Sakurai ,  Akio Kayano ,  Hiroyuki Ishizuka ,  Hiroyuki Saito ,  Taiju Nakamura ,  Ikuo Kushida ,  Yasuyuki Suzuki ,  Takako Yoshiba ,  Kazuhide Ashizawa ,  Masahiro Sakurai ,  Eiichi Yamamoto

Inventor： Hiroyuki Chiba ,  Masahiko Tsujii ,  Astsushi Koiwa ,  Shin Sakurai ,  Akio Kayano ,  Hiroyuki Ishizuka ,  Hiroyuki Saito ,  Taiju Nakamura ,  Ikuo Kushida ,  Yasuyuki Suzuki ,  Takako Yoshiba ,  Kazuhide Ashizawa ,  Masahiro Sakurai ,  Eiichi Yamamoto

IPC: C07D477/20 ,  A61K31/407 ,  A61P31/04

CPC classification number: C07D477/20 ,  A61K31/407

Abstract: The present invention provides carbapenem hydrochloride trihydrate crystals, which are chemically stable, easily purified and useful as antimicrobial agents, a process for producing them, and a powdery charged preparation for injection containing them. That is, it provides carbapenem hydrochloride trihydrate crystals having a powdery X-ray diffraction pattern containing lattice distances (d) of 9.0, 4.1 and 2.8 Å, a process for producing them, and a powdery charged preparation for injection containing them.

Abstract translation: 本发明提供化学稳定，易于纯化和用作抗微生物剂的盐酸碳青霉烯盐酸盐三水合物晶体，其制备方法和含有它们的注射用粉末状药物制剂。 也就是说，它提供了具有包含晶格距离（d）为9.0,4.1和2.8的粉末X射线衍射图的碳青霉烯盐酸盐三水合物晶体，其制备方法和含有它们的注射用粉末状药物制剂。