公开(公告)号：US08053462B2

公开(公告)日：2011-11-08

申请号：US10591899

申请日：2005-03-04

申请人： Masanori Somei ,  Atsuhiko Hattori ,  Nobuo Suzuki

发明人： Masanori Somei ,  Atsuhiko Hattori ,  Nobuo Suzuki

IPC分类号： A01N43/38 ,  A61K31/405 ,  C07D209/16

CPC分类号： C07D209/30 ,  C07D209/14

摘要： This invention relates to a compound represented by formula (I) or a salt thereof, and a therapeutic agent for osteoporosis, an osteoblast activator, and an osteoclast suppressor comprising the same: wherein X represents a halogen atom; R1 represents a hydrogen atom, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, a substituted or unsubstituted aromatic group, substituted or unsubstituted aralkyl, substituted or unsubstituted acyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted C1-6 alkylsulfonyl, or hydroxyl; R2 represents substituted or unsubstituted C1-21 alkyl; R3, R5 and R6, which may be the same or different, each represent a hydrogen atom or a halogen atom; and R4 represents a hydrogen atom or substituted or unsubstituted C1-6 alkyl.

摘要翻译： 本发明涉及由式（I）表示的化合物或其盐，以及骨质疏松症治疗剂，成骨细胞激活剂和破骨细胞抑制剂，其中X表示卤素原子; R 1表示氢原子，取代或未取代的C 1-6烷基，取代或未取代的C 2-6烯基，取代或未取代的C 2-6炔基，取代或未取代的芳基，取代或未取代的芳烷基，取代或未取代的酰基，取代或未取代的 取代或未取代的C 1-6烷基磺酰基或羟基; R2代表取代或未取代的C 1-12烷基; R 3，R 5和R 6可以相同或不同，各自表示氢原子或卤素原子; 并且R 4表示氢原子或取代或未取代的C 1-6烷基。

公开(公告)号：US07659304B2

公开(公告)日：2010-02-09

申请号：US12007992

申请日：2008-01-17

申请人： Masanori Somei ,  Atsuhiko Hattori ,  Nobuo Suzuki

发明人： Masanori Somei ,  Atsuhiko Hattori ,  Nobuo Suzuki

IPC分类号： A61K31/405 ,  C07D209/12

CPC分类号： C07D209/30

摘要： A compound represented by the following formula (I) or a salt thereof is provided: wherein X represents a halogen atom; R1 represents a hydrogen atom, substituted or unsubstituted C1-6 alkyl group, substituted or unsubstituted C2-6 alkenyl group, substituted or unsubstituted C2-6 alkynyl group, substituted or unsubstituted aromatic group, substituted or unsubstituted aralkyl group, substituted or unsubstituted acyl group, substituted or unsubstituted arylsulfonyl group, substituted or unsubstituted C1-6 alkylsulfonyl group, substituted or unsubstituted C2-7 alkoxycarbonyl group, or hydroxyl group; R2 represents a substituted or unsubstituted C1-21 alkyl group; R3, R5, and R6 are the same or different and represent a hydrogen atom or halogen atom; R4 represents a hydrogen atom or substituted or unsubstituted C1-6 alkyl group; and R7 represents a hydrogen atom or substituted or unsubstituted C1-21 hydrocarbon group. Also provided is a therapeutic drug for osteoporosis and an osteoblast activator comprising the compound or a salt thereof.

摘要翻译： 提供由下式（I）表示的化合物或其盐：其中X表示卤素原子; R 1表示氢原子，取代或未取代的C 1-6烷基，取代或未取代的C 2-6烯基，取代或未取代的C 2-6炔基，取代或未取代的芳基，取代或未取代的芳烷基，取代或未取代的酰基 取代或未取代的芳基磺酰基，取代或未取代的C 1-6烷基磺酰基，取代或未取代的C 2-7烷氧基羰基或羟基; R2表示取代或未取代的C1〜21烷基; R3，R5和R6相同或不同，表示氢原子或卤素原子; R4表示氢原子或取代或未取代的C1-6烷基; 并且R 7表示氢原子或取代或未取代的C 1-11烃基。 还提供了用于骨质疏松症的治疗药物和包含该化合物或其盐的成骨细胞活化剂。

公开(公告)号：US20090054511A1

公开(公告)日：2009-02-26

申请号：US12007992

申请日：2008-01-17

申请人： Masanori Somei ,  Atsuhiko Hattori ,  Nobuo Suzuki

发明人： Masanori Somei ,  Atsuhiko Hattori ,  Nobuo Suzuki

IPC分类号： A61K31/404 ,  C07D209/20 ,  A61P19/10

CPC分类号： C07D209/30

摘要： It is intended to provide a tryptophan derivative that activates osteoblasts and to provide a therapeutic drug for osteoporosis and an osteoblast activator using this tryptophan derivative.This invention relates to a compound represented by the following formula (I) or a salt thereof: wherein X represents a halogen atom; R1 represents a hydrogen atom, substituted or unsubstituted C1-6 alkyl group, substituted or unsubstituted C2-6 alkenyl group, substituted or unsubstituted C2-6 alkynyl group, substituted or unsubstituted aromatic group, substituted or unsubstituted aralkyl group, substituted or unsubstituted acyl group, substituted or unsubstituted arylsulfonyl group, substituted or unsubstituted C1-6 alkylsulfonyl group, substituted or unsubstituted C2-7 alkoxycarbonyl group, or hydroxyl group; R2 represents a substituted or unsubstituted C1-21 alkyl group; R3, R5, and R6 are the same or different and represent a hydrogen atom or halogen atom; R4 represents a hydrogen atom or substituted or unsubstituted C1-6 alkyl group; and R7 represents a hydrogen atom or substituted or unsubstituted C1-21 hydrocarbon group, and to a therapeutic drug for osteoporosis and an osteoblast activator comprising the compound or a salt thereof.

摘要翻译： 旨在提供活化成骨细胞的色氨酸衍生物并提供用于骨质疏松症的治疗药物和使用该色氨酸衍生物的成骨细胞激活剂。 本发明涉及由下式（I）表示的化合物或其盐：其中X表示卤素原子; R 1表示氢原子，取代或未取代的C 1-6烷基，取代或未取代的C 2-6烯基，取代或未取代的C 2-6炔基，取代或未取代的芳基，取代或未取代的芳烷基，取代或未取代的酰基 取代或未取代的芳基磺酰基，取代或未取代的C 1-6烷基磺酰基，取代或未取代的C 2-7烷氧基羰基或羟基; R2表示取代或未取代的C1〜21烷基; R3，R5和R6相同或不同，表示氢原子或卤素原子; R4表示氢原子或取代或未取代的C1-6烷基; R7代表氢原子或取代或未取代的C1-21烃基，以及含有该化合物或其盐的骨质疏松症治疗药物和成骨细胞激活剂。

公开(公告)号：US20070197629A1

公开(公告)日：2007-08-23

申请号：US10591899

申请日：2005-03-04

申请人： Masanori Somei ,  Atsuhiko Hattori ,  Nobuo Suzuki

发明人： Masanori Somei ,  Atsuhiko Hattori ,  Nobuo Suzuki

IPC分类号： A61K31/405

CPC分类号： C07D209/30 ,  C07D209/14

摘要： This invention relates to a compound represented by formula (I) or a salt thereof, and a therapeutic agent for osteoporosis, an osteoblast activator, and an osteoclast suppressor comprising the same: wherein X represents a halogen atom; R1 represents a hydrogen atom, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, a substituted or unsubstituted aromatic group, substituted or unsubstituted aralkyl, substituted or unsubstituted acyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted C1-6 alkylsulfonyl, or hydroxyl; R2 represents substituted or unsubstituted C1-21 alkyl; R3, R5 and R6, which may be the same or different, each represent a hydrogen atom or a halogen atom; and R4 represents a hydrogen atom or substituted or unsubstituted C1-6 alkyl.

摘要翻译： 本发明涉及由式（I）表示的化合物或其盐，骨质疏松症治疗剂，成骨细胞激活剂和破骨细胞抑制剂，其中X表示卤素原子; R 1表示氢原子，取代或未取代的C 1-6烷基，取代或未取代的C 2-6烯基，取代或未取代的C 取代或未取代的芳基，取代或未取代的芳烷基，取代或未取代的酰基，取代或未取代的芳基磺酰基，取代或未取代的C 1-6烷基磺酰基， 或羟基; R 2表示取代或未取代的C 1-12烷基; R 3，R 5和R 6可以相同或不同，各自表示氢原子或卤素原子; R 4表示氢原子或取代或未取代的C 1-6烷基。

公开(公告)号：US06560863B2

公开(公告)日：2003-05-13

申请号：US09924807

申请日：2001-08-08

申请人： Toshinori Koyama ,  Mikiko Kobayashi ,  Atsuhiko Hattori

发明人： Toshinori Koyama ,  Mikiko Kobayashi ,  Atsuhiko Hattori

IPC分类号： H05K310

CPC分类号： H05K3/4661 ,  H05K3/381 ,  H05K3/4602 ,  H05K2203/095 ,  Y10T29/49117 ,  Y10T29/49128 ,  Y10T29/49144 ,  Y10T29/49155 ,  Y10T29/49156

摘要： A method of producing a wiring board having a plurality of wiring layers each being located on an electrical insulation layer, in which an electrical insulation layer is formed on a substrate using a resin material, and a conductor layer is formed on the surface of the electrical insulation layer by successive electroless plating and electroplating with copper, and is patterned to form a wiring layer, wherein, after the formation of the electrical insulation layer on the substrate, the electrical insulation layer is subjected to a plasma treatment and a subsequent ultraviolet treatment, and the electroless plating and the electroplating are then performed.