公开(公告)号：US06156513A

公开(公告)日：2000-12-05

申请号：US130888

申请日：1998-08-07

申请人： Ramareddy V. Guntaka ,  Karl T. Weber ,  Attilla Kovacs ,  Jagannadhachari Kandala

发明人： Ramareddy V. Guntaka ,  Karl T. Weber ,  Attilla Kovacs ,  Jagannadhachari Kandala

IPC分类号： A61K38/00 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/63 ,  C12N15/85 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C07H21/00 ,  A61K38/00 ,  C12N2310/15 ,  C12N2310/152

摘要： Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen-gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide or a ribonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1(I) collagen gene.

摘要翻译： 描述抑制胶原基因表达的寡聚物。 据信每个寡聚体在被引入细胞时形成由低聚物和胶原 - 基因启动子区构成的转录抑制复合物。 寡聚物，优选硫代磷酸酯脱氧寡核苷酸或核糖核苷酸，优选以反向平行取向结合哺乳动物α1（I）胶原基因启动子区的聚脲 - 多嘧啶区域的聚脲链。

公开(公告)号：US5808037A

公开(公告)日：1998-09-15

申请号：US712357

申请日：1996-09-11

申请人： Ramareddy V. Guntaka ,  Karl Theodore Weber ,  Attilla Kovacs ,  Jagannadhachari Kandala

发明人： Ramareddy V. Guntaka ,  Karl Theodore Weber ,  Attilla Kovacs ,  Jagannadhachari Kandala

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P1/00 ,  A61P1/16 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P17/02 ,  C12N15/113 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/85

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/15 ,  C12N2310/315 ,  C12N2310/3181

摘要： Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen-gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1(I) collagen gene.

摘要翻译： 描述抑制胶原基因表达的寡聚物。 据信每个寡聚体在被引入细胞时形成由低聚物和胶原 - 基因启动子区构成的转录抑制复合物。 寡聚物，优选硫代磷酸酯脱氧寡核苷酸，优选以反向平行取向结合哺乳动物α1（I）胶原基因的启动子区的聚脲 - 多嘧啶区域的多元链。